Drug & supplement interaction

Spleen Extract + Teplizumab-mzwv

Teplizumab-mzwv brand name: Tzield.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Spleen Extract and Teplizumab-mzwv in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Spleen Extract and Teplizumab-mzwv

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Teplizumab-mzwv and Spleen Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Spleen Extract at all — not against Teplizumab-mzwv, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Spleen Extract safety at a glance

Spleen Extract overall Use caution Human evidence is limited and animal-tissue products carry possible contamination and infection concerns.
Pregnancy Avoid There is no safety data in pregnancy, so it is best avoided.
Breastfeeding Avoid No safety information exists for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Teplizumab-mzwv and Spleen Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Teplizumab-mzwv’s Own FDA Label Lists

This is not an interaction — none of it involves Spleen Extract. These are the most notable effects listed in the ADVERSE REACTIONS section of Teplizumab-mzwv’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Blood clots Worth acting on
  • Wheezing Worth acting on
  • A low platelet count Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Chills

Showing the 10 most notable of 21 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Teplizumab-mzwv. Read the label on DailyMed › Spleen Extract’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Spleen Extract side to compare — that is a limit of the record, not a statement that Spleen Extract has no side effects.

Everything else you take

See Every Supplement That Interacts With Teplizumab-mzwv

This page covers Spleen Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Teplizumab-mzwv page lists 89 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Active Hexose Correlated Compound (ahcc) (moderate) and Alfalfa (moderate).

By severity: 3 major · 85 moderate · 1 minor.

From our pharmacist’s overview on the Teplizumab-mzwv page

“Siberian cocklebur is the single riskiest item here for anyone on teplizumab-mzwv (Tzield), the infusion given to delay the onset of type 1 diabetes. That herb has caused liver injury and outright liver failure on its own, and 38 of the 89 interacting ingredients on this page share that liver theme, including beer and wine, which carry…”

Reviewed by 2 · Jul 18, 2026

Open the Teplizumab-mzwv interaction page

One more smart check

Taking Spleen Extract as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Spleen Extract, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Spleen Extract. Even though Spleen Extract itself has no known interaction with Teplizumab-mzwv, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Spleen Extract and Teplizumab-mzwv Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Spleen Extract
Steady interest

#955 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Teplizumab-mzwv
Top 25%

#499 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Spleen Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Spleen Extract and Teplizumab-mzwv records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Spleen Extract

What is Spleen Extract?

  • Immune support
  • Low white blood cell counts
  • General "glandular" support
  • Boosting energy or vitality

Spleen extract is a glandular supplement made from the spleen tissue of animals such as cows or pigs, promoted mainly for immune support. There is very little reliable human research to show it works, and because it is an animal tissue product there are real safety questions, including possible infection risk. Talk with your pharmacist or doctor before using it.

Spleen tissue, usually from cattle (bovine) or pigs (porcine) · Capsules, tablets, sometimes injectable forms (older or non-standard products)

An interaction check asks whether these two react with each other — it does not ask whether Spleen Extract is a good idea for someone in your situation. Here is what our Spleen Extract record says about it on its own.

Spleen Extract: dosing

There is no established or standardized dose for spleen extract. Products vary widely in how they are made and what they contain.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Spleen Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Spleen Extract monograph & all interactions
Medication

About Teplizumab-mzwv injection

What Is Teplizumab-mzwv injection Used For?

Brand name: Tzield

Tzield is used to delay the onset of Stage 3 type 1 diabetes (T1D) in adults and children aged 1 year and older who already have Stage 2 T1D — meaning their immune system is attacking insulin-producing cells, but they don't yet have overt high blood sugar symptoms.

Tzield is also used to slow the loss of the body's own insulin production in children and teenagers aged 8 to 17 years who have recently been diagnosed with Stage 3 T1D. This second use is approved under accelerated approval, meaning continued approval depends on results from ongoing confirmatory studies.

See full Teplizumab-mzwv injection drug information
Keep checking

Other Drugs & Spleen Extract

Browse every other medication we’ve checked against Spleen Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Spleen Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Spleen Extract list.

See the full Spleen Extract interactions page
See every supplement checked against Teplizumab-mzwv, ranked by severity
Evidence & sources

Spleen Extract References

The 1 references that drive our Spleen Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Spleen Extract and Teplizumab-mzwv Together: Common Questions

Is it safe to take Spleen Extract with Teplizumab-mzwv?
We do not list a known interaction between Spleen Extract and Teplizumab-mzwv. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Teplizumab-mzwv interact with any supplements?
Yes. Teplizumab-mzwv has documented interactions with 89 supplements in our database — Spleen Extract is not one of them. The Teplizumab-mzwv interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Spleen Extract monograph Uses, safety profile, and every drug interaction in one place Teplizumab-mzwv injection drug information The full plain-English guide to this medication Teplizumab-mzwv supplement interactions Every supplement checked against Teplizumab-mzwv, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Teplizumab-mzwv and Spleen Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.