Drug & supplement interaction

Squalamine + Amivantamab-Vmjw

Amivantamab-Vmjw brand name: Rybrevant.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Amivantamab-Vmjw in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squalamine and Amivantamab-Vmjw

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amivantamab-Vmjw and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Amivantamab-Vmjw, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amivantamab-Vmjw and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Squalamine and Amivantamab-Vmjw May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Squalamine

    “Topically and intravenously, squalamine seems to be well tolerated; however, a thorough safety evaluation has not been conducted.

    Most Common Adverse Effects:

    Intravenously: Fatigue, loss of appetite, myalgia, nausea, transaminitis, vomiting.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    Amivantamab-Vmjw

    Listed in the ADVERSE REACTIONS section of the FDA label for Amivantamab-Vmjw. Read the label on DailyMed ›

  • Reduced appetite / Vomiting / Nausea Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Amivantamab-Vmjw

    Listed in the ADVERSE REACTIONS section of the FDA label for Amivantamab-Vmjw. Read the label on DailyMed ›

  • Muscle pain Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate myalgias and muscle cramps in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in muscle cramps.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Amivantamab-Vmjw

    Listed in the ADVERSE REACTIONS section of the FDA label for Amivantamab-Vmjw. Read the label on DailyMed ›

  • Tiredness Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Amivantamab-Vmjw

    Listed in the ADVERSE REACTIONS section of the FDA label for Amivantamab-Vmjw. Read the label on DailyMed ›

Reported for Squalamine but not commonly for Amivantamab-Vmjw: yellowing of the skin or eyes.

Effects for Amivantamab-Vmjw come from the ADVERSE REACTIONS section of its FDA label; effects for Squalamine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Amivantamab-Vmjw Is Prescribed For, and What Squalamine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Amivantamab-Vmjw is a prescription medicine with approved uses on its FDA label. Squalamine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Amivantamab-Vmjw is prescribed for: Rybrevant (amivantamab-vmjw) is used to treat adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) that carries specific changes (mutations) in the EGFR gene. The exact regimen depends on which mutation is present and whether prior treatment has been received. Rybrevant is used: in combination with lazertinib as a first-line treatment for NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations; in combination with carboplatin and pemetrexed for those same mutations when the cancer progressed after an EGFR tyrosine kinase inhibitor; in combination with carboplatin and pemetrexed as a first-line treatment for NSCLC with EGFR exon 20 insertion mutations; and as a single agent for NSCLC with exon 20 insertion mutations when the cancer progressed after platinum-based chemotherapy. In every case, patients must first be confirmed to carry the relevant mutation by an FDA-approved test.

Squalamine has been studied for:

  • Lung cancer studied, not established Squalamine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Squalamine for lung cancer

    It is unclear if intravenous squalamine is beneficial in patients with lung cancer.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Amivantamab-Vmjw on your own; if you are taking Squalamine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

How much people look this up

Where Squalamine and Amivantamab-Vmjw Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#843 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amivantamab-Vmjw
Top half

#1,186 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Squalamine and Amivantamab-Vmjw records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Medication

About Amivantamab-vmjw Injection

What Is Amivantamab-vmjw Injection Used For?

Brand name: Rybrevant

Rybrevant (amivantamab-vmjw) is used to treat adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) that carries specific changes (mutations) in the EGFR gene. The exact regimen depends on which mutation is present and whether prior treatment has been received.

Rybrevant is used: in combination with lazertinib as a first-line treatment for NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations; in combination with carboplatin and pemetrexed for those same mutations when the cancer progressed after an EGFR tyrosine kinase inhibitor; in combination with carboplatin and pemetrexed as a first-line treatment for NSCLC with EGFR exon 20 insertion mutations; and as a single agent for NSCLC with exon 20 insertion mutations when the cancer progressed after platinum-based chemotherapy. In every case, patients must first be confirmed to carry the relevant mutation by an FDA-approved test.

See full Amivantamab-vmjw Injection drug information
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Amivantamab-Vmjw, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Amivantamab-Vmjw Together: Common Questions

Is it safe to take Squalamine with Amivantamab-Vmjw?
We do not list a known interaction between Squalamine and Amivantamab-Vmjw. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squalamine and Amivantamab-Vmjw have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Squalamine and Amivantamab-Vmjw used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Squalamine in each. That is a conversation for your prescriber, especially if Amivantamab-Vmjw is being adjusted to a target.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Amivantamab-vmjw Injection drug information The full plain-English guide to this medication Amivantamab-Vmjw supplement interactions Every supplement checked against Amivantamab-Vmjw, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.