Squalamine + Dabrafenib
Dabrafenib brand name: Tafinlar.
We found no known interaction between Squalamine and Dabrafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dabrafenib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Squalamine and Dabrafenib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dabrafenib and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Dabrafenib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Squalamine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Dabrafenib Products Have a Food Rule — Squalamine Should Not Break It
At least one FDA label for a product containing Dabrafenib says to take it on an empty stomach. Most supplements — Squalamine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Dabrafenib on its own and move Squalamine to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dabrafenib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
TAFINLAR Capsules Take TAFINLAR capsules on an empty stomach (at least 1 hour before or 2 hours after a meal) [see Clinical Pharmacology (12.3)] .
From the Dosage and Administration section of the FDA label we read for Dabrafenib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Dabrafenib Is Prescribed For, and What Squalamine Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Dabrafenib is a prescription medicine with approved uses on its FDA label. Squalamine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Dabrafenib is prescribed for: Dabrafenib is used to treat cancers that carry a specific change (mutation) in the BRAF gene — most often called a BRAF V600E or V600K mutation. These mutations cause cancer cells to grow out of control. Before starting this medicine, a tumor test must confirm the mutation is present. It can be used alone or — more commonly — paired with another targeted drug, trametinib.
Read the rest of what Dabrafenib is prescribed for
Conditions it treats include advanced or inoperable melanoma (skin cancer), certain lung cancers, anaplastic thyroid cancer, low-grade brain tumors (glioma) in children, and other solid tumors with the same mutation that haven't responded to prior treatment.
Squalamine has been studied for:
-
Lung cancer studied, not established Squalamine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Squalamine for lung cancer
It is unclear if intravenous squalamine is beneficial in patients with lung cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dabrafenib on your own; if you are taking Squalamine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Dabrafenib
This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dabrafenib page lists 154 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 112 moderate · 39 minor.
Where Squalamine and Dabrafenib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#952 of 1,452 supplements looked up here in the last 7 days
#1,464 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Squalamine and Dabrafenib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Squalamine
What is Squalamine?
- Cancer (investigational)
- Age-related macular degeneration (eye disease)
- Antimicrobial / antiviral interest
- Anti-angiogenesis (blocking new blood vessel growth)
Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.
Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement
An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.
Squalamine: dosing
There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.
From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.
About Dabrafenib
What Is Dabrafenib Used For?
Brand name: Tafinlar
Dabrafenib is used to treat cancers that carry a specific change (mutation) in the BRAF gene — most often called a BRAF V600E or V600K mutation. These mutations cause cancer cells to grow out of control. Before starting this medicine, a tumor test must confirm the mutation is present.
It can be used alone or — more commonly — paired with another targeted drug, trametinib. Conditions it treats include advanced or inoperable melanoma (skin cancer), certain lung cancers, anaplastic thyroid cancer, low-grade brain tumors (glioma) in children, and other solid tumors with the same mutation that haven't responded to prior treatment.
Other Drugs & Squalamine
Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amitriptyline ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bupropion ›
- Bendamustine ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.
Squalamine References
The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Squalamine and Dabrafenib Together: Common Questions
Is it safe to take Squalamine with Dabrafenib?
Do Squalamine and Dabrafenib have any of the same side effects?
Should I take Squalamine and Dabrafenib at the same time of day?
Are Squalamine and Dabrafenib used for the same thing?
Does Dabrafenib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.