Drug & supplement interaction

Squalamine + Thioridazine

Thioridazine brand name: Mellaril.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Thioridazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squalamine and Thioridazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Thioridazine and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Thioridazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Thioridazine and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Squalamine and Thioridazine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    Squalamine

    “Intravenously, squalamine at doses above 192 mg/m2 daily has been associated with reports of elevated hepatic transaminase levels. Levels of aspartate aminotransferase and alanine aminotransferase were about 5 to over 20 times above upper normal levels in some patients. The increased levels were noted 2-5 days after beginning squalamine. Both values returned to baseline within 6-23 days.”

    Squalamine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Thioridazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioridazine. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Squalamine

    “Topically and intravenously, squalamine seems to be well tolerated; however, a thorough safety evaluation has not been conducted.

    Most Common Adverse Effects:

    Intravenously: Fatigue, loss of appetite, myalgia, nausea, transaminitis, vomiting.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    Thioridazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioridazine. Read the label on DailyMed ›

  • Reduced appetite / Vomiting / Nausea Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Thioridazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioridazine. Read the label on DailyMed ›

  • Tiredness Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Thioridazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Thioridazine. Read the label on DailyMed ›

Reported for Squalamine but not commonly for Thioridazine: muscle pain.

Effects for Thioridazine come from the ADVERSE REACTIONS section of its FDA label; effects for Squalamine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Squalamine or Thioridazine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Squalamine or Thioridazine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Thioridazine

This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Thioridazine page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 11 major · 125 moderate · 32 minor.

From our pharmacist’s overview on the Thioridazine page

“Thioridazine (Mellaril) is an older antipsychotic already known for disturbing the heart's rhythm, and the supplements that worry me most here do the same thing, stretching the QT interval further. Grapefruit in large amounts sits in that group, alongside ephedra and several other major-rated entries.”

Reviewed by 2 · Jul 18, 2026

Open the Thioridazine interaction page

How much people look this up

Where Squalamine and Thioridazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#959 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Thioridazine
Steady interest

#2,091 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Squalamine and Thioridazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Medication

About Thioridazine

What Is Thioridazine Used For?

Brand name: Mellaril

Thioridazine Hydrochloride tablets are used for the management of schizophrenia — but only in patients who have already tried at least two other antipsychotic medications without adequate results, either because those drugs didn't work well enough or caused intolerable side effects.

Because thioridazine carries serious heart-rhythm risks, it is considered a last-resort option for schizophrenia, not a first-line treatment. It is not approved for dementia-related psychosis or any other psychiatric condition.

See full Thioridazine drug information
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Thioridazine, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Thioridazine Together: Common Questions

Is it safe to take Squalamine with Thioridazine?
We do not list a known interaction between Squalamine and Thioridazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squalamine and Thioridazine have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Thioridazine interact with any supplements?
Yes. Thioridazine has documented interactions with 168 supplements in our database — Squalamine is not one of them. The Thioridazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Thioridazine drug information The full plain-English guide to this medication Thioridazine supplement interactions Every supplement checked against Thioridazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Thioridazine and Squalamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.