Drug & supplement interaction

Stone Root + Ondansetron

Ondansetron brand name: Zofran.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Stone Root and Ondansetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Stone Root and Ondansetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ondansetron and Stone Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Stone Root at all — not against Ondansetron, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stone Root safety at a glance

Stone Root overall Use caution Little safety data exists, so use with care and under professional guidance.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ondansetron and Stone Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Stone Root Itself Has Been Linked To

This is not an interaction — nothing below involves Ondansetron. It is the side-effect record for Stone Root on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Stone Root, this list is the first place to look.

  • Dizziness / Nausea Additional detail

    “Orally, large amounts of stone root can cause intestinal tract irritation and colic-like pain dizziness, and nausea (18).”

    Stone Root · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Stone Root — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ondansetron’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ondansetron column appears here.

From our Q&A

Questions About Stone Root or Ondansetron

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Stone Root or Ondansetron, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ondansetron

This page covers Stone Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ondansetron page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 145 moderate · 46 minor.

From our pharmacist’s overview on the Ondansetron page

“Ondansetron (Zofran) often stands between you and relentless nausea from chemotherapy or surgery, so read this page carefully. Four of the 195 ingredients rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Ondansetron interaction page

One more smart check

Taking Stone Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Stone Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stone Root. Even though Stone Root itself has no known interaction with Ondansetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stone Root and Ondansetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stone Root
Top half

#650 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ondansetron
Top half

#1,381 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stone Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Stone Root and Ondansetron records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stone Root

What is Stone Root?

Stone Root
  • Hemorrhoids
  • Urinary and bladder discomfort
  • Digestive upset
  • Sore throat and hoarseness
  • Kidney stones (traditional)

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

Collinsonia canadensis · Lamiaceae · Root and rhizome · Tincture, capsules, dried root for tea, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Stone Root is a good idea for someone in your situation. Here is what our Stone Root record says about it on its own.

Stone Root: dosing

There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.The safest approach is to follow the directions on the product label and not exceed them.

From our Stone Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stone Root monograph & all interactions
Medication

About Ondansetron

What Is Ondansetron Used For?

Brand name: Zofran

Ondansetron is used to prevent nausea and vomiting in several situations. Oral forms (tablets, orally disintegrating tablets, and oral solution) are approved to prevent nausea and vomiting from highly or moderately emetogenic (nausea-causing) cancer chemotherapy, from radiation therapy to the abdomen or whole body, and from surgery.

Ondansetron injection (given intravenously or intramuscularly in a clinical setting) is approved to prevent nausea and vomiting from emetogenic cancer chemotherapy — including high-dose cisplatin — in adults and children as young as 6 months old, as well as to prevent postoperative nausea and vomiting.

Most-Reported Side Effects for Ondansetron

From FAERS, the FDA’s public side-effect reporting system (121,840 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 14,459 reports
Fatigue 10,275 reports
Diarrhea 9,488 reports
Vomiting 8,777 reports
Dyspnea 5,971 reports
See full Ondansetron drug information
Keep checking

Other Drugs & Stone Root

Browse every other medication we’ve checked against Stone Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Stone Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stone Root list.

See the full Stone Root interactions page
See every supplement checked against Ondansetron, ranked by severity
Evidence & sources

Stone Root References

The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stone Root and Ondansetron Together: Common Questions

Is it safe to take Stone Root with Ondansetron?
We do not list a known interaction between Stone Root and Ondansetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ondansetron interact with any supplements?
Yes. Ondansetron has documented interactions with 195 supplements in our database — Stone Root is not one of them. The Ondansetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stone Root monograph Uses, safety profile, and every drug interaction in one place Ondansetron drug information The full plain-English guide to this medication Ondansetron supplement interactions Every supplement checked against Ondansetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ondansetron and Stone Root?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.