Drug & supplement interaction

Sulbutiamine + Interferon Beta-1a

Interferon Beta-1a brand names: Rebif, Avonex.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Sulbutiamine and Interferon Beta-1a in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sulbutiamine and Interferon Beta-1a

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Interferon Beta-1a and Sulbutiamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sulbutiamine at all — not against Interferon Beta-1a, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sulbutiamine safety at a glance

Sulbutiamine overall Use caution Generally well tolerated short-term, but long-term safety and quality of evidence are limited.

Pregnancy Avoid Not enough safety data; avoid use during pregnancy.

Breastfeeding Avoid Not enough safety data; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Interferon Beta-1a and Sulbutiamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Sulbutiamine Itself Has Been Linked To

This is not an interaction — nothing below involves Interferon Beta-1a. It is the side-effect record for Sulbutiamine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Sulbutiamine, this list is the first place to look.

Tremor or shakiness / Drowsiness / Trouble sleeping / Headache Additional detail
“Cases of headache, insomnia, tremor, and drowsiness were each reported in one patient (0.06% of patients) using a combination of anti-infective medication and sulbutiamine.”

Sulbutiamine · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

24374. Shah S. Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. J Assoc Physicians India. 2003;51:891-5.
Nausea Additional detail
“Five cases of nausea have been reported for patients using a combination of anti-infective medication and sulbutiamine.”

Sulbutiamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

24374. Shah S. Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. J Assoc Physicians India. 2003;51:891-5.

Everything above comes from the Natural Medicines adverse-effect record for Sulbutiamine — expand a row for the licensed statement it rests on. We haven’t matched Interferon Beta-1a to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Interferon Beta-1a.

Everything else you take

See Every Supplement That Interacts With Interferon Beta-1a

This page covers Sulbutiamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Beta-1a page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 3 major · 53 moderate · 1 minor.

From our pharmacist’s overview on the Interferon Beta-1a page

“Siberian cocklebur, an herb tied to documented cases of liver failure, is the first name to know for anyone injecting interferon beta-1a (Rebif, Avonex) for multiple sclerosis. Interferon beta-1a can strain the liver on its own, which is why prescribers order routine liver blood tests, and 38 of the 57 supplements on file carry that sa…”

Reviewed by 2 · Jul 18, 2026

Open the Interferon Beta-1a interaction page

One more smart check

Taking Sulbutiamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 64 real supplement products containing Sulbutiamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sulbutiamine. Even though Sulbutiamine itself has no known interaction with Interferon Beta-1a, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sulbutiamine and Interferon Beta-1a Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sulbutiamine

Steady interest

#1,081 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Interferon Beta-1a

Steady interest

#1,800 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sulbutiamine reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sulbutiamine and Interferon Beta-1a records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Sulbutiamine

What is Sulbutiamine?

Fatigue and low energy
Memory and focus
Mental clarity
Mood support
Vitamin B1 deficiency support

Sulbutiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) developed in Japan, often taken for fatigue and to support mental energy and focus. Human evidence is limited and mostly older or small, so its real benefits are uncertain. It is generally well tolerated short-term, but you should talk with a pharmacist or doctor before using it, especially if you have a health condition.

Synthetic compound (not from a plant) · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Sulbutiamine is a good idea for someone in your situation. Here is what our Sulbutiamine record says about it on its own.

Sulbutiamine: dosing

There is no firmly established standard dose for sulbutiamine as a supplement. Amounts used in older studies and on product labels vary, and there is not enough strong evidence to recommend one clear dose.The safest approach is to follow the directions on the product label and not take more than suggested.

From our Sulbutiamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sulbutiamine monograph & all interactions

Medication

About Interferon Beta-1a Intramuscular Injection

What Is Interferon Beta-1a Intramuscular Injection Used For?

Brand names: Rebif, Avonex

Interferon beta-1a intramuscular injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:
- clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),
- relapsing-remitting forms (course of disease where symptoms flare up from time to time), or
- secondary progressive forms (course of disease where relapses occur more often).
Interferon beta-1a is in a class of medications called immunomodulators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.

Most-Reported Side Effects for Interferon Beta-1a

From FAERS, the FDA’s public side-effect reporting system (192,069 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Multiple sclerosis relapse 15,851 reports

Influenza like illness 13,253 reports

Fatigue 11,554 reports

Fall 10,604 reports

Multiple sclerosis 9,358 reports

See full Interferon Beta-1a Intramuscular Injection drug information

Keep checking

Other Drugs & Sulbutiamine

Browse every other medication we’ve checked against Sulbutiamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Sulbutiamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sulbutiamine list.

See the full Sulbutiamine interactions page

See every supplement checked against Interferon Beta-1a, ranked by severity

Evidence & sources

Sulbutiamine References

The 4 references that drive our Sulbutiamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Shah S. Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. J Assoc Physicians India. 2003;51:891-5.
Loo H, Poirier M, Ollat H, et al. [Effects of subutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes]. Encephale. 2000;26(2):70-5.
Kiew K, Wan Mohamad W, Ridzuan A, et al. Effects of sulbutiamine on diabetic polyneuropathy: an open randomized controlled study in type 2 diabetics. Malays J Med Sci. 2002;9(1):21-7.
Sevim S, Kaleagasi H, Tasdelen B. Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis. Mult Scler Relat Disord. 2017;16:40-43. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sulbutiamine and Interferon Beta-1a Together: Common Questions

Is it safe to take Sulbutiamine with Interferon Beta-1a?

We do not list a known interaction between Sulbutiamine and Interferon Beta-1a. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Interferon Beta-1a interact with any supplements?

Yes. Interferon Beta-1a has documented interactions with 57 supplements in our database — Sulbutiamine is not one of them. The Interferon Beta-1a interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sulbutiamine monograph Uses, safety profile, and every drug interaction in one place Interferon Beta-1a Intramuscular Injection drug information The full plain-English guide to this medication Interferon Beta-1a supplement interactions Every supplement checked against Interferon Beta-1a, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Interferon Beta-1a and Sulbutiamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.