Sumbul + Sofosbuvir, Velpatasvir, Voxilaprevir
Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.
We found no known interaction between Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to.
Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Sumbul in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Sumbul at all — not against Sofosbuvir, Velpatasvir, Voxilaprevir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Sumbul safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Sumbul in Pregnancy & Breastfeeding
When sumbul leaves are used orally. After a breastfeeding parent consumed sumbul leaves, both the parent and breastfeeding infant experienced several episodes of vomiting two hours later, suggesting that sumbul leaf constituents may pass through breast milk. There is insufficient reliable information available about the effects of sumbul root products during lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Sumbul Should Not Break It
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Sumbul on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. See the Sofosbuvir, Velpatasvir, Voxilaprevir drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir
This page covers Sumbul only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 130 moderate · 40 minor.
From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page
“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”
Reviewed by 2 · Jul 18, 2026
Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page
Taking Sumbul as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4 real supplement products containing Sumbul, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sumbul. Even though Sumbul itself has no known interaction with Sofosbuvir, Velpatasvir, Voxilaprevir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,153 of 1,452 supplements looked up here in the last 7 days
#676 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sumbul reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Sumbul
What is Sumbul?
- Nervous tension and anxiety
- Muscle spasms and cramps
- Menstrual discomfort
- Digestive upset
- Traditional aphrodisiac
Sumbul is a musky-smelling root from a Ferula plant that has been used in traditional medicine mainly as a calming, antispasmodic remedy. There is very little modern scientific research to confirm any of its benefits, and its safety has not been well studied. Talk with a pharmacist or doctor before using it.
Ferula sumbul · Apiaceae · Root (rhizome) · Tincture, fluid extract, dried root, powder
An interaction check asks whether these two react with each other — it does not ask whether Sumbul is a good idea for someone in your situation. Here is what our Sumbul record says about it on its own.
Sumbul: dosing
There is no standardized, well-established dose for Sumbul. Historical doses were given as tinctures or fluid extracts, but those figures come from old herbal references and may not be safe or reliable today.If you choose to use a Sumbul product, follow the directions on the label and do not exceed them.
From our Sumbul monograph — the full record covers uses, side effects and every documented interaction.
About Sofosbuvir, Velpatasvir, and Voxilaprevir
What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?
Brand name: Vosevi
Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option.
Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.
Other Drugs & Sumbul
Browse every other medication we’ve checked against Sumbul — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Sumbul against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Valacyclovir ›
- Tirzepatide ›
- Methamphetamine ›
- Hydroxyurea ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Isotretinoin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Dextroamphetamine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sumbul list.
Sumbul References
The 1 references that drive our Sumbul monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Derin H, Yildirim G, Çaksen H. Intoxication from Ferula sumbul leaves in a mother and her infant. J Pediatr Intensive Care 2013;2(4):193-4.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions
Is it safe to take Sumbul with Sofosbuvir, Velpatasvir, Voxilaprevir?
Should I take Sumbul and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.