Drug & supplement interaction

Sweet Gale + Entrectinib

Entrectinib brand name: Rozlytrek.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sweet Gale and Entrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sweet Gale and Entrectinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Entrectinib and Sweet Gale in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Gale at all — not against Entrectinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Gale safety at a glance

Sweet Gale overall Use caution Limited safety data and a volatile oil that may be toxic in higher amounts.
Pregnancy Avoid Traditionally avoided in pregnancy and not enough safety data exists.
Breastfeeding Avoid No reliable safety information during breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Entrectinib and Sweet Gale? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Entrectinib’s Own FDA Label Lists

This is not an interaction — none of it involves Sweet Gale. These are the most notable effects listed in the ADVERSE REACTIONS section of Entrectinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Loss of vision Worth acting on
  • Bone thinning Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • High potassium Worth acting on
  • Unsteadiness Worth acting on
  • Blood clots Worth acting on
  • Hallucinations Worth acting on

Showing the 10 most notable of 53 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 1,653 voluntary FDA FAERS reports for Entrectinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Sweet Gale’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Sweet Gale side to compare — that is a limit of the record, not a statement that Sweet Gale has no side effects.

Everything else you take

See Every Supplement That Interacts With Entrectinib

This page covers Sweet Gale only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entrectinib page lists 175 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 127 moderate · 37 minor.

From our pharmacist’s overview on the Entrectinib page

“Grapefruit tops my worry list for anyone taking entrectinib (Rozlytrek), a targeted cancer therapy cleared by the liver enzyme CYP3A4. 121 of the 175 supplement ingredients on this page can shift how that enzyme handles the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Entrectinib interaction page

How much people look this up

Where Sweet Gale and Entrectinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Gale
Steady interest

#1,313 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Entrectinib
Top half

#1,026 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sweet Gale and Entrectinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Gale

What is Sweet Gale?

  • Insect repellent
  • Digestive complaints
  • Flavoring for food and beverages
  • Skin and itch relief (traditional)
  • Aromatic and fragrance use

Sweet gale is an aromatic shrub long used as an insect repellent and a flavoring herb, but there is very little solid human research supporting any health benefit. Its essential oil is considered potentially toxic, so internal use should be approached with great caution and avoided in pregnancy. Talk to a pharmacist or doctor before using it.

Myrica gale · Myricaceae · Leaves, branches, fruit (catkins), and wax/essential oil · Tea, dried leaves, essential oil, flavoring agent

An interaction check asks whether these two react with each other — it does not ask whether Sweet Gale is a good idea for someone in your situation. Here is what our Sweet Gale record says about it on its own.

Sweet Gale: dosing

There is no established or standardized dose for sweet gale. Because reliable human research is lacking, no safe and effective amount has been defined for any health condition.If you choose to use a sweet gale product, follow the directions on the label and do not exceed them. Avoid swallowing the essential oil.

From our Sweet Gale monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Gale monograph & all interactions
Medication

About Entrectinib

What Is Entrectinib Used For?

Brand name: Rozlytrek

Rozlytrek (entrectinib) is used to treat adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as confirmed by an FDA-approved test. It is also approved for adult and pediatric patients older than 1 month of age who have solid tumors — any cancer type — that carry an NTRK gene fusion detected by an FDA-approved test, provided the tumor has no known acquired resistance mutation, is metastatic or cannot be surgically removed without severe harm, and has progressed after prior treatment or has no satisfactory alternative therapy.

The NTRK gene fusion approval in solid tumors was granted under accelerated approval, meaning it is based on tumor response rates. Continued approval may depend on results from confirmatory clinical trials.

Most-Reported Side Effects for Entrectinib

From FAERS, the FDA’s public side-effect reporting system (1,653 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 150 reports
Disease progression 117 reports
Taste disorder 71 reports
Constipation 66 reports
Blood creatinine increased 62 reports
See full Entrectinib drug information
Keep checking

Other Drugs & Sweet Gale

Browse every other medication we’ve checked against Sweet Gale — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Gale against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Gale list.

See the full Sweet Gale interactions page
See every supplement checked against Entrectinib, ranked by severity
Sources

Sources & How We Checked

We checked Sweet Gale against Entrectinib in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Sweet Gale monograph › Uses, safety, and every drug interaction in one place Entrectinib supplement interactions › Every supplement checked against Entrectinib, ranked by severity Entrectinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Sweet Gale and Entrectinib Together: Common Questions

Is it safe to take Sweet Gale with Entrectinib?
We do not list a known interaction between Sweet Gale and Entrectinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Entrectinib interact with any supplements?
Yes. Entrectinib has documented interactions with 175 supplements in our database — Sweet Gale is not one of them. The Entrectinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Entrectinib and Sweet Gale?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.