Drug & supplement interaction

Sweet Sumac + Tamoxifen Citrate

Tamoxifen Citrate brand names: Nolvadex, Soltamox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Sweet Sumac and Tamoxifen Citrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sweet Sumac and Tamoxifen Citrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tamoxifen Citrate and Sweet Sumac in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Sumac at all — not against Tamoxifen Citrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Sumac safety at a glance

Sweet Sumac overall Use caution Limited safety data exist, and it is related to plants that can cause skin reactions.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Safety is unknown while breastfeeding, so it is best to avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tamoxifen Citrate and Sweet Sumac? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Sweet Sumac and Tamoxifen Citrate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Sweet Sumac

    “Orally, infections of the urogenital tract have been reported in women with overactive bladder who were taking a combination product (Granu Fink femina, Omega Pharma) containing sweet sumac bark extract, pumpkin seed oil, and hops cone extract. It is unclear if these adverse effects were due to sweet sumac, other ingredients, or the combination.”

    Sweet Sumac · Natural Medicines adverse-effect record, reported in overactive bladder.

    1 source cited
    1. 103253. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

    Tamoxifen Citrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Tamoxifen Citrate. Read the label on DailyMed ›

Effects for Tamoxifen Citrate come from the ADVERSE REACTIONS section of its FDA label; effects for Sweet Sumac come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Sweet Sumac or Tamoxifen Citrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Sweet Sumac or Tamoxifen Citrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tamoxifen Citrate

This page covers Sweet Sumac only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tamoxifen Citrate page lists 210 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 166 moderate · 33 minor.

From our pharmacist’s overview on the Tamoxifen Citrate page

“Tamoxifen (Nolvadex, Soltamox) often stands between a breast cancer patient and a recurrence, so the stakes on this page run higher than usual. Eleven of the 210 supplements and herbs on file carry a major rating, and those eleven deserve your attention ahead of everything else.”

Reviewed by 2 · Jul 18, 2026

Open the Tamoxifen Citrate interaction page

How much people look this up

Where Sweet Sumac and Tamoxifen Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Sumac
Steady interest

#1,192 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tamoxifen Citrate
Top 10%

#151 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Sumac reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Sweet Sumac and Tamoxifen Citrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Sumac

What is Sweet Sumac?

  • Urinary complaints
  • Diarrhea
  • Excessive urination or bedwetting
  • Sore throat and mouth rinse
  • Mild bleeding

Sweet Sumac (Rhus aromatica) is a North American shrub used in traditional and folk medicine, mostly for urinary and digestive complaints. There is very little modern human research to confirm that it works for any condition, so its benefits remain unproven. Because it belongs to the same plant family as poison ivy, talk with a pharmacist or doctor before using it.

Rhus aromatica · Anacardiaceae · Bark of the root, leaves, and berries · Dried bark, tea, tincture, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Sweet Sumac is a good idea for someone in your situation. Here is what our Sweet Sumac record says about it on its own.

Sweet Sumac: dosing

There is no established, standardized dose for Sweet Sumac. It has traditionally been taken as a tea, tincture, or liquid extract made from the root bark or leaves, but reliable dosing guidelines from clinical research are not available.If you choose to use a commercial product, follow the directions on the label and do not exceed the suggested amount.

From our Sweet Sumac monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Sumac monograph & all interactions
Medication

About Tamoxifen

What Is Tamoxifen Used For?

Brand names: Nolvadex, Soltamox

Tamoxifen is used to treat metastatic breast cancer (breast cancer that has spread) in both women and men, and as adjuvant (after-surgery) therapy for early-stage breast cancer in women. It also reduces the occurrence of cancer in the opposite breast when used as adjuvant therapy.

In women with ductal carcinoma in situ (DCIS) — a very early, non-invasive form of breast cancer — tamoxifen is used after breast surgery and radiation to reduce the risk of developing invasive breast cancer. It is also approved to reduce the incidence of breast cancer in women who are at high risk but have not yet been diagnosed. Soltamox (oral solution) is specifically indicated for all of these uses in adult patients.

See full Tamoxifen drug information
Keep checking

Other Drugs & Sweet Sumac

Browse every other medication we’ve checked against Sweet Sumac — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Sumac against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Sumac list.

See the full Sweet Sumac interactions page
See every supplement checked against Tamoxifen Citrate, ranked by severity
Evidence & sources

Sweet Sumac References

The 1 references that drive our Sweet Sumac monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Sumac and Tamoxifen Citrate Together: Common Questions

Is it safe to take Sweet Sumac with Tamoxifen Citrate?
We do not list a known interaction between Sweet Sumac and Tamoxifen Citrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sweet Sumac and Tamoxifen Citrate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Tamoxifen Citrate interact with any supplements?
Yes. Tamoxifen Citrate has documented interactions with 210 supplements in our database — Sweet Sumac is not one of them. The Tamoxifen Citrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Sumac monograph Uses, safety profile, and every drug interaction in one place Tamoxifen drug information The full plain-English guide to this medication Tamoxifen Citrate supplement interactions Every supplement checked against Tamoxifen Citrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tamoxifen Citrate and Sweet Sumac?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.