Drug & supplement interaction

Tannic Acid + Desflurane

Desflurane brand name: Suprane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tannic Acid and Desflurane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tannic Acid and Desflurane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Desflurane and Tannic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tannic Acid at all — not against Desflurane, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tannic Acid safety at a glance

Tannic Acid overall Use caution Generally used topically in small amounts, but absorption through broken skin or large burns can harm the liver.
Pregnancy Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during preg... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Desflurane and Tannic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tannic Acid and Desflurane May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Tannic Acid

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11). Extensive use of tannins on burns or in enemas has been associated with fatal liver damage (11). However, this toxicity may be due to digallic acid, an impurity that is sometimes found in tannic acid (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in burns.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    “Extensive use of tannins on burns or in enemas has been associated with fatal liver damage (11). However, this toxicity may be due to digallic acid, an impurity that is sometimes found in tannic acid (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in burns.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Tannic Acid

    “Orally, large amounts of tannic acid can cause gastric irritation, nausea, and vomiting (11).”

    Tannic Acid · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Desflurane

    Listed in the ADVERSE REACTIONS section of the FDA label for Desflurane. Read the label on DailyMed ›

Reported for Tannic Acid but not commonly for Desflurane: stomach upset.

Effects for Desflurane come from the ADVERSE REACTIONS section of its FDA label; effects for Tannic Acid come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tannic Acid in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used topically on damaged or broken skin. There is insufficient reliable information available about the safety of tannic acid when used orally during pregnancy and lactation; avoid using amounts greater than those found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Desflurane

This page covers Tannic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desflurane page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Fever Bark (major), Cannabis (moderate), Coffee Charcoal (moderate) and Cowhage (moderate).

By severity: 2 major · 11 moderate · 9 minor.

From our pharmacist’s overview on the Desflurane page

“The interaction to understand first is fever bark with desflurane, the inhaled anesthetic that keeps patients asleep during surgery. Fever bark contains reserpine, tied to unstable heart function and blood pressure under general anesthesia, and it carries one of two major ratings among the 22 supplements on file.”

Reviewed by 2 · Jul 18, 2026

Open the Desflurane interaction page

How much people look this up

Where Tannic Acid and Desflurane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tannic Acid
Steady interest

#1,297 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Desflurane
Top half

#1,381 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tannic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tannic Acid and Desflurane records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tannic Acid

What is Tannic Acid?

  • Minor skin irritation and weeping rashes
  • Sore throat and mouth sores
  • Minor burns and blisters
  • Astringent for skin
  • Hemorrhoids

Tannic acid is a plant-derived astringent used mostly on the skin and in the mouth to dry out and tighten tissue. There is some traditional and topical use, but high-quality evidence for most uses is limited, and it can be harmful if too much is absorbed, especially on broken skin or burns.

Tannins extracted from plant sources such as oak galls, bark, and certain seeds and leaves · Topical powders and solutions, throat lozenges, gargles, suppositories, and some over-the-counter skin products

An interaction check asks whether these two react with each other — it does not ask whether Tannic Acid is a good idea for someone in your situation. Here is what our Tannic Acid record says about it on its own.

Tannic Acid: dosing

There is no well-established standard dose of tannic acid for supplement use. The amount varies widely depending on the product and how it is used (for example, a skin solution versus a lozenge).The safest approach is to follow the directions on the product label and not apply it to large areas of broken or burned skin.

From our Tannic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tannic Acid monograph & all interactions
Medication

About Desflurane

What Is Desflurane Used For?

Brand name: Suprane

Desflurane (available as Desflurane USP and Suprane) is a general anesthetic given by inhalation during surgery. In adults, it is approved both to start (induce) anesthesia and to keep it going (maintain) throughout inpatient and outpatient procedures.

In infants and children, desflurane is approved only for maintaining anesthesia — and only after anesthesia has first been started with a different agent and the child has been intubated (a breathing tube placed). It is not approved to start anesthesia in children, and it must not be used to maintain anesthesia in children who are not intubated.

See full Desflurane drug information
Keep checking

Other Drugs & Tannic Acid

Browse every other medication we’ve checked against Tannic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tannic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tannic Acid list.

See the full Tannic Acid interactions page
See every supplement checked against Desflurane, ranked by severity
Evidence & sources

Tannic Acid References

The 8 references that drive our Tannic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised contr
  5. Smith DB, Jacobson BH. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. J Chiropr Med. 2011;10(3) PubMed
  6. Goh CL, Yoyong K. A comparison of topical tannic acid versus iontophoresis in the medical treatment of palmar hyperhidrosis. Singapore Med J. 1996;37(5):466-8.
  7. Kołodziej M, Bebenek D, Konarska Z, Szajewska H. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018;8(5):e020205. PubMed
  8. Mennini M, Tolone C, Frassanito A, Midulla F, Cucchiara S, Aloi M. Gelatin tannate for acute childhood gastroenteritis: a randomized, single-blind controlled trial. Paediatr Drugs. 2017 Apr;19(2):131-137. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tannic Acid and Desflurane Together: Common Questions

Is it safe to take Tannic Acid with Desflurane?
We do not list a known interaction between Tannic Acid and Desflurane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tannic Acid and Desflurane have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Desflurane interact with any supplements?
Yes. Desflurane has documented interactions with 22 supplements in our database — Tannic Acid is not one of them. The Desflurane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tannic Acid monograph Uses, safety profile, and every drug interaction in one place Desflurane drug information The full plain-English guide to this medication Desflurane supplement interactions Every supplement checked against Desflurane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Desflurane and Tannic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.