Drug & supplement interaction

Tansy + Metoprolol

Metoprolol brand names: Lopressor, Toprol XL.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Tansy and Metoprolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metoprolol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tansy and Metoprolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metoprolol and Tansy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tansy safety at a glance

Tansy overall Avoid Tansy contains thujone, which can be poisonous, so internal use is generally discouraged.
Pregnancy Likely Unsafe When used orally or topically due to potential abortifacient, menstrual flow, and uterine stimulant effects. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally due to thujone content. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metoprolol and Tansy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metoprolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoprolol is filed under 6 classifications — including beta-blockers, antihypertensive drugs, cytochrome p450 2d6 (cyp2d6) substrates. Tansy has documented interactions with 1 drug class — the most serious being alcohol (ethanol) (major) — and none of Metoprolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tansy Does Interact With Other Medications

Tansy has 1 major, known drug interaction in our database — Metoprolol isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Tansy

Covers the 2,830 medications we’ve checked against Tansy. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Tansy and Metoprolol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Fainting Worth acting on Additional detail

    Tansy

    “Orally, varieties of tansy that contain the toxic constituent thujone have been reported to cause thujone toxicity. Neurologic symptoms include loss of consciousness, tremors, seizures, and vertigo (2,18,77012).”

    Tansy · Natural Medicines adverse-effect record, reported in epilepsy.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    3. 77012. McGuffin M and et al. American Herbal Products Association's Botanical Safety Handbook. 1997.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Tansy

    “There is limited reliable information available about the adverse effects of tansy. Orally, varieties of tansy that contain the toxic constituent thujone have been reported to cause thujone toxicity. Symptoms of thujone toxicity include rapid pulse, irregular heartbeat, tachypnea, severe gastroenteritis, vomiting, dilated pupils, hepatotoxicity, nephrotoxicity, and death (4,6,77012,77014,77015).”

    Tansy · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 77012. McGuffin M and et al. American Herbal Products Association's Botanical Safety Handbook. 1997.
    4. 77014. The Review of Natural Products by Facts and Comparisons. 1999.
    5. 77015. Blumenthal, M and et al. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998;
    6. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Bleeding or bruising Worth acting on Additional detail

    Tansy

    “Orally, large doses of tansy have been reported to induce abortion and uterine bleeding.”

    Tansy · Natural Medicines adverse-effect record, reported in abortion.

    1 source cited
    1. 77015. Blumenthal, M and et al. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998;

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Sun sensitivity / A skin rash Additional detail

    Tansy

    “Topically, atopic dermatitis has been reported from members of the Compositae family, of which tansy is a member. Photosensitivity, typically presenting as eczema, has also been reported from contact with members of the Compositae family.”

    Tansy · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 46978. Guin, J. D. and Skidmore, G. Compositae dermatitis in childhood. Arch Dermatol. 1987;123(4):500-502. DOI
    2. 77007. Jovanovic, M., Poljacki, M., Duran, V., Vujanovic, L., Sente, R., and Stojanovic, S. Contact allergy to Compositae plants in patients with atopic dermatitis. Med Pregl. 2004;57(5-6):209-218. PubMed
    3. 77011. Mark, K. A., Brancaccio, R. R., Soter, N. A., and Cohen, D. E. Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens. Arch Dermatol. 1999;135(1):67-70. PubMed
    4. 42856. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Tansy

    Recorded for Tansy in the same Natural Medicines adverse-effect record shown under Liver problems above.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Dizziness Additional detail

    Tansy

    Recorded for Tansy in the same Natural Medicines adverse-effect record shown under Fainting above.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

  • Vomiting Additional detail

    Tansy

    “Orally, varieties of tansy that contain the toxic constituent thujone have been reported to cause thujone toxicity. Gastrointestinal symptoms include severe gastroenteritis, vomiting, and abdominal pain.”

    Tansy · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 77012. McGuffin M and et al. American Herbal Products Association's Botanical Safety Handbook. 1997.

    Metoprolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed ›

Reported for Tansy but not commonly for Metoprolol: an irregular heartbeat, stomach pain, kidney problems and seizures.

Effects for Metoprolol come from the ADVERSE REACTIONS section of its FDA label; effects for Tansy come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tansy in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally or topically due to potential abortifacient, menstrual flow, and uterine stimulant effects.

Lactation Likely Unsafe

When used orally due to thujone content.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Metoprolol Products Have a Food Rule — Tansy Should Not Break It

At least one FDA label for a product containing Metoprolol says to take it with food. If you take Tansy on an empty stomach out of habit, keep them separate — and take Metoprolol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metoprolol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer once daily with food or after a meal.

From the Dosage and Administration section of the FDA label we read for Metoprolol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Tansy or Metoprolol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tansy or Metoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metoprolol

This page covers Tansy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 152 moderate · 26 minor.

From our pharmacist’s overview on the Metoprolol page

“With metoprolol (Lopressor, Toprol XL), a beta-blocker for high blood pressure and heart problems, these interactions deserve genuine care, starting with the five rated major. Most entries pull blood pressure one way or the other: many supplements add to metoprolol's lowering effect and can drop pressure too far, while a few, tyramine…”

Reviewed by 2 · Jul 18, 2026

Open the Metoprolol interaction page

One more smart check

Taking Tansy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 45 real supplement products containing Tansy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tansy. Even though Tansy itself has no known interaction with Metoprolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tansy and Metoprolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tansy
Steady interest

#911 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metoprolol
Top 10

#7 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tansy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tansy and Metoprolol records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tansy

What is Tansy?

  • Intestinal worms and parasites
  • Digestive upset
  • Menstrual problems
  • Insect repellent
  • Skin and wound care (traditional)

Tansy is a traditional bitter herb that contains thujone, a compound that can be toxic in higher amounts. Because of real safety concerns and very limited modern evidence, most people should avoid taking tansy internally, and it should never be used during pregnancy.

Tanacetum vulgare · Asteraceae · Flowers, leaves, and essential oil · Tea, dried herb, tincture, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Tansy is a good idea for someone in your situation. Here is what our Tansy record says about it on its own.

Tansy: dosing

There is no established safe or standardized dose of tansy. Never use the concentrated essential oil internally, and follow all product labels carefully. In most cases, a safer alternative is the better choice.

From our Tansy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tansy monograph & all interactions
Medication

About Metoprolol

What Is Metoprolol Used For?

Brand names: Lopressor, Toprol XL

Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack.

Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy. Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.

Most-Reported Side Effects for Metoprolol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 23,416 reports
Dyspnea 20,183 reports
Diarrhea 19,912 reports
Nausea 19,659 reports
Dizziness 16,726 reports
See full Metoprolol drug information
Keep checking

Other Drugs & Tansy

Browse every other medication we’ve checked against Tansy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
0Moderate
0Minor
2,828No known interaction
Major

1 interaction

No interaction 2,828 drugs checked — show the list
Evidence & sources

Tansy References

The 14 references that drive our Tansy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  6. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  7. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  8. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  9. Guin, J. D. and Skidmore, G. Compositae dermatitis in childhood. Arch Dermatol. 1987;123(4):500-502. DOI
  10. Jovanovic, M., Poljacki, M., Duran, V., Vujanovic, L., Sente, R., and Stojanovic, S. Contact allergy to Compositae plants in patients with atopic dermatitis. Med Pregl. 2004;57(5-6):209-218. PubMed
  11. Mark, K. A., Brancaccio, R. R., Soter, N. A., and Cohen, D. E. Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens. Arch Dermatol. 1999;135(1):67-70. PubMed
  12. McGuffin M and et al. American Herbal Products Association's Botanical Safety Handbook. 1997.
  13. The Review of Natural Products by Facts and Comparisons. 1999.
  14. Blumenthal, M and et al. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998;

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tansy and Metoprolol Together: Common Questions

Is it safe to take Tansy with Metoprolol?
We do not list a known interaction between Tansy and Metoprolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tansy and Metoprolol have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Tansy and Metoprolol at the same time of day?
At least one FDA label for a product containing Metoprolol says to take it with food. If you take Tansy on an empty stomach out of habit, keep them separate and take Metoprolol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Metoprolol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Tansy and Metoprolol combination checked?
Interactions in our licensed database are recorded against drug classes. Metoprolol is filed under 6 classifications, and Tansy has documented interactions with 1 drug class — none of Metoprolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Tansy interact with any other medications?
Yes. Tansy has 1 documented drug interaction in our database — Metoprolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metoprolol interact with any supplements?
Yes. Metoprolol has documented interactions with 183 supplements in our database — Tansy is not one of them. The Metoprolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Metoprolol and Tansy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.