Drug & supplement interaction

Thyme + Voclosporin

Voclosporin brand name: Lupkynis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Thyme and Voclosporin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Voclosporin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Thyme and Voclosporin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voclosporin and Thyme in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Thyme safety at a glance

Thyme overall Use caution Generally safe as a food and in tea, but the concentrated essential oil can be toxic if swallowed.
Pregnancy Likely Safe When used in amounts commonly found in foods. Thyme has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information availab... Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. Thyme has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information availab... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voclosporin and Thyme? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Voclosporin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Voclosporin is filed under 4 classifications — including qt interval-prolonging drugs, nephrotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Thyme has documented interactions with 4 drug classes — the most serious being anticholinergic drugs (moderate), anticoagulant/antiplatelet drugs (moderate) and cholinergic drugs (moderate) — and none of Voclosporin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Thyme Does Interact With Other Medications

Thyme has 379 moderate known drug interactions in our database — Voclosporin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 379 No known interaction 2,451 (incl. Voclosporin)
Taking anything else?

Check Another of Your Medications Against Thyme

Covers the 2,830 medications we’ve checked against Thyme. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Thyme and Voclosporin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Thyme

    “Orally, thyme is well tolerated when used in food and seems to be well tolerated when used medicinally. Topically, thyme seems to be generally well tolerated.

    Most Common Adverse Effects:

    Orally: Allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting.

    Topically: Contact dermatitis and skin irritation.”

    Thyme · Natural Medicines adverse-effect record, reported in cluster headache.

    Voclosporin

    Listed in the ADVERSE REACTIONS section of the FDA label for Voclosporin. Read the label on DailyMed ›

  • Stomach upset Additional detail

    Thyme

    “Orally, thyme and thyme oil may cause heartburn, nausea, vomiting, stomach upset, or diarrhea. In a clinical study, two patients using extracts of thyme herb and ivy leaves experienced temporary stomach ache and mild nausea.

    Intravaginally, cream containing thyme and garlic has been associated with reports of nausea and vomiting in one clinical study.”

    Thyme · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 13557. Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
    2. 94033. Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed
    3. 78181. Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
    4. 88387. Bahadoran P, Rokni FK, Fahami F. Investigating the therapeutic effect of vaginal cream containing garlic and thyme compared to clotrimazole cream for the treatment of mycotic vaginitis. Iran J Nurs Midwifery Res 2010;15(Suppl 1):343-9.

    Voclosporin

    Listed in the ADVERSE REACTIONS section of the FDA label for Voclosporin. Read the label on DailyMed ›

  • Diarrhea / Nausea / Vomiting reported in 7.2% of FDA reports for Voclosporin Additional detail

    Thyme

    Recorded for Thyme in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Voclosporin

    Listed in the ADVERSE REACTIONS section of the FDA label for Voclosporin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache / Dizziness reported in 7.9% of FDA reports for Voclosporin Additional detail

    Thyme

    “Orally, thyme may case headache or dizziness.”

    Thyme · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 94033. Erol S, Aydin B, Dilli D, Okumus N, Zenciroglu A, Gündüz M. An interesting newborn case of fructose 1-6 diphosphatase deficiency triggered after thyme juice ingestion. Clin Lab. 2014;60(1):151-3. PubMed

    Voclosporin

    Listed in the ADVERSE REACTIONS section of the FDA label for Voclosporin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Thyme but not commonly for Voclosporin: a skin rash and heartburn.

Effects for Voclosporin come from the ADVERSE REACTIONS section of its FDA label; effects for Thyme come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,444 voluntary FDA FAERS reports for Voclosporin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Thyme in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts commonly found in foods. Thyme has Generally Recognized as Safe (GRAS) status in the US. There is insufficient reliable information available about the safety of thyme when used in medicinal amounts during pregnancy and breast-feeding; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Voclosporin Products Have a Food Rule — Thyme Should Not Break It

At least one FDA label for a product containing Voclosporin says to take it on an empty stomach. Most supplements — Thyme included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Voclosporin on its own and move Thyme to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Voclosporin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Administration : LUPKYNIS must be swallowed whole on an empty stomach.

From the Dosage and Administration section of the FDA label we read for Voclosporin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Voclosporin

This page covers Thyme only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voclosporin page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Cesium (major).

By severity: 10 major · 101 moderate · 41 minor.

Open the Voclosporin interaction page

One more smart check

Taking Thyme as Part of a Dietary Supplement Product? Check It for Interactions

We hold 708 real supplement products containing Thyme, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Thyme. Even though Thyme itself has no known interaction with Voclosporin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Thyme and Voclosporin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Thyme
Top 25%

#227 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voclosporin
Top 25%

#628 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Thyme reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Thyme and Voclosporin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Thyme

What is Thyme?

Thyme
  • Cough and respiratory congestion
  • Sore throat
  • Digestive upset
  • Antimicrobial and antiseptic uses
  • Flavoring in cooking

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that combine thyme with other herbs have modest supporting evidence, but high-quality research on thyme alone is limited. The concentrated essential oil should never be swallowed undiluted.

Thymus vulgaris · Lamiaceae · Leaves, flowering tops, and essential oil · Tea, dried herb, liquid extract, capsules, essential oil, syrups, and lozenges

An interaction check asks whether these two react with each other — it does not ask whether Thyme is a good idea for someone in your situation. Here is what our Thyme record says about it on its own.

Thyme: dosing

There is no official standardized dose for thyme. The right amount depends on the form you are using, such as tea, extract, or a combination cough product.The safest approach is to follow the directions on the product label and not exceed them.

From our Thyme monograph — the full record covers uses, side effects and every documented interaction.

Read the full Thyme monograph & all interactions
Medication

About Voclosporin

What Is Voclosporin Used For?

Brand name: Lupkynis

Lupkynis (voclosporin) is approved for adults with active lupus nephritis (LN) — a serious kidney complication of lupus. It is always used alongside a background immunosuppressive regimen, specifically mycophenolate mofetil (MMF) and corticosteroids.

Lupkynis is not recommended in combination with cyclophosphamide, as safety and efficacy in that combination have not been established.

See full Voclosporin drug information
Keep checking

Other Drugs & Thyme

Browse every other medication we’ve checked against Thyme — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
379Moderate
0Minor
2,450No known interaction
379 Moderate 2,450 No interaction
Moderate

379 interactions

Showing 60 of 379 moderate interactions — see all 379 on the Thyme page.

No interaction 2,450 drugs checked — show the list

We also checked Thyme against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,450 medications checked with no known interaction — see the full Thyme list.

See the full Thyme interactions page
See every supplement checked against Voclosporin, ranked by severity
Evidence & sources

Thyme References

The 18 references that drive our Thyme monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Okazaki K, Kawazoe K, Takaishi Y. Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 2002;16:398-9. .
  4. Spiewak R, Skorska C, Dutkiewicz J. Occupational airborne contact dermatitis caused by thyme dust. Contact Dermatitis 2001;44:235-9. . PubMed
  5. Ernst E, Marz R, Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1997;4:287-93. PubMed
  6. Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
  7. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  8. Mackiewicz, B., Skorska, C., Dutkiewicz, J., Michnar, M., Milanowski, J., Prazmo, Z., Krysinska-Traczyk, E., and Cisak, E. Allergic alveolitis due to herb dust exposure. Ann Agric Environ Med 1999;6(2):167-170.
  9. Martinez-Gonzalez, M. C., Goday Bujan, J. J., Martinez, Gomez W., and Fonseca, Capdevila E. Concomitant allergic contact dermatitis due to Rosmarinus officinalis (rosemary) and Thymus vulgaris (thyme). Contact Dermatitis 2007;56(1):49-50.
  10. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261.
  11. Marzian, O. [Treatment of acute bronchitis in children and adolescents. Non-interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves]. MMW.Fortschr.Med 6-28-2007;149(27-28 Suppl
  12. Cuzzolin, L. and Benoni, G. Attitudes and knowledge toward natural products safety in the pharmacy setting: an Italian study. Phytother.Res 2009;23(7):1018-1023. PubMed
  13. Berova, N., Stransky, L., and Krasteva, M. Studies on contact dermatitis in stomatological staff. Dermatol.Monatsschr. 1990;176(1):15-18.
  14. Smeenk, G., Kerckhoffs, H. P., and Schreurs, P. H. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br.J Dermatol. 1987;116(2):223-231.
  15. Le Roy, R., Grosshans, E., and Foussereau, J. [Investigation of contact allergies in 100 cases of ulcus cruris (author's transl)]. Derm.Beruf.Umwelt. 1981;29(6):168-170.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Thyme and Voclosporin Together: Common Questions

Is it safe to take Thyme with Voclosporin?
We do not list a known interaction between Thyme and Voclosporin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Thyme and Voclosporin have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Thyme and Voclosporin at the same time of day?
At least one FDA label for a product containing Voclosporin says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Voclosporin on its own and move Thyme to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Thyme and Voclosporin combination checked?
Interactions in our licensed database are recorded against drug classes. Voclosporin is filed under 4 classifications, and Thyme has documented interactions with 4 drug classes — none of Voclosporin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Thyme interact with any other medications?
Yes. Thyme has 379 documented drug interactions in our database — Voclosporin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Voclosporin interact with any supplements?
Yes. Voclosporin has documented interactions with 152 supplements in our database — Thyme is not one of them. The Voclosporin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Thyme monograph Uses, safety profile, and every drug interaction in one place Voclosporin drug information The full plain-English guide to this medication Voclosporin supplement interactions Every supplement checked against Voclosporin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Voclosporin and Thyme?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.