Drug & supplement interaction

Tin + Canagliflozin, Metformin

Canagliflozin, Metformin brand name: Invokamet.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Tin and Canagliflozin, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Canagliflozin, Metformin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tin and Canagliflozin, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Canagliflozin, Metformin and Tin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tin at all — not against Canagliflozin, Metformin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tin safety at a glance

Tin overall Use caution Tin is not an essential nutrient and some tin compounds can be harmful, so supplementing is not recommended without medical advice.
Pregnancy Avoid There is no proven benefit and unknown safety, so avoid tin supplements during pregnancy.
Breastfeeding Avoid Safety is not established, so avoid tin supplements while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Canagliflozin, Metformin and Tin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tin and Canagliflozin, Metformin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Diarrhea / Nausea Additional detail

    Tin

    “Orally, intake of food contaminated with large amounts of tin may cause gastrointestinal effects, including diarrhea, stomach pain, nausea, and anemia.

    Topically, dentifrices and mouthwashes containing tin as stannous fluoride or stannous chloride may cause teeth staining or tongue discoloration.

    When inhaled long-term, tin may cause stannosis.”

    Tin · Natural Medicines adverse-effect record, reported in anemia.

    5 sources cited
    1. 28635. US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
    2. 28648. Paraskevas, S. and van der Weijden, G. A. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006;33(1):1-13. PubMed
    3. 94409. Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
    4. 101106. Lorenz K, Hoffmann T, Heumann C, Noack B. Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. Int J Dent Hyg. 2019;17(3):237-243. PubMed
    5. 106016. Frese C, Wohlrab T, Sheng L, Kieser M, Krisam J, Wolff D. Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study. Sci Rep 2019;9(1):7681. PubMed

    “Orally, intake of food contaminated with large amounts of tin may cause gastrointestinal effects. Several cases of gastrointestinal events, including diarrhea, stomach pain, nausea, and/or gastroenteritis have been reported for patients who ingested foods contaminated with tin from tin cans. The dose of tin contained in these foods ranged from 250-1000 mg/kg body weight.”

    Tin · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 28635. US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
    2. 28650. Blunden, S. and Wallace, T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-1662. PubMed

    Canagliflozin, Metformin

    Listed in the ADVERSE REACTIONS section of the FDA label for Canagliflozin, Metformin. Read the label on DailyMed ›

Reported for Tin but not commonly for Canagliflozin, Metformin: anemia.

Effects for Canagliflozin, Metformin come from the ADVERSE REACTIONS section of its FDA label; effects for Tin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Canagliflozin, Metformin Products Have a Food Rule — Tin Should Not Break It

At least one FDA label for a product containing Canagliflozin, Metformin says to take it with food. If you take Tin on an empty stomach out of habit, keep them separate — and take Canagliflozin, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Canagliflozin, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

INVOKAMET: take one tablet orally twice daily with meals ( 2.2 ).

From the Dosage and Administration section of the FDA label we read for Canagliflozin, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Canagliflozin, Metformin

This page covers Tin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Canagliflozin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Canagliflozin, Metformin page

“Invokamet combines canagliflozin and metformin, two medicines that lower blood sugar by different routes, so nearly everything here, 239 of the 257 ingredients on file, touches glucose control in one direction or the other. Most add their own sugar-lowering effect and can stack with the drug to drop blood sugar too far, while a few pus…”

Reviewed by 2 · Jul 18, 2026

Open the Canagliflozin, Metformin interaction page

One more smart check

Taking Tin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 384 real supplement products containing Tin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tin. Even though Tin itself has no known interaction with Canagliflozin, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tin and Canagliflozin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tin
Top half

#369 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Canagliflozin, Metformin
Steady interest

#1,877 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tin and Canagliflozin, Metformin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tin

What is Tin?

  • Marketed as a trace mineral supplement
  • Claimed support for general 'mineral balance'
  • Sometimes promoted for skin or hair (unproven)

Tin is a metallic element found in tiny amounts in the diet, but it is not considered an essential nutrient for humans and there is no proven health benefit to taking it as a supplement. Because some tin compounds can be toxic, there is little reason to take tin on purpose, and you should talk to a pharmacist or doctor before using any product that contains it.

Tin is a chemical element (Sn); the form used in supplements is the trace mineral, not a plant part · Trace amounts in some multivitamin/mineral products; stannous salts are used in some toothpastes (not as a supplement)

An interaction check asks whether these two react with each other — it does not ask whether Tin is a good idea for someone in your situation. Here is what our Tin record says about it on its own.

Tin: dosing

There is no established or recommended dose of tin as a supplement, because it is not known to be an essential nutrient. No official daily requirement has been set for humans.If a product you are considering lists tin, follow the label and keep the amount low, but understand there is no proven reason to take it.

From our Tin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tin monograph & all interactions
Keep checking

Other Drugs & Tin

Browse every other medication we’ve checked against Tin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tin list.

See the full Tin interactions page
See every supplement checked against Canagliflozin, Metformin, ranked by severity
Evidence & sources

Tin References

The 8 references that drive our Tin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. US Department of Health and Human Services. Toxicological profile for tin and tin compounds. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp55.pdf
  2. Paraskevas, S. and van der Weijden, G. A. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006;33(1):1-13. PubMed
  3. Blunden, S. and Wallace, T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-1662. PubMed
  4. Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
  5. Feng X, Chen X, Cheng R, Sun L, Zhang Y, He T. Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent. 2010;23 Spec No B:27B-31B.
  6. Milleman JL, Milleman KR, Santos SL, Proskin HM, Battershell KK, DiMarino JC. Subjective assessment of Enamelon® preventive treatment gel in a self-reported dry-mouth population. Compend Contin Educ Dent. 2016;37(8):e5-8.
  7. Lorenz K, Hoffmann T, Heumann C, Noack B. Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. Int J Dent Hyg. 2019;17(3):237-243. PubMed
  8. Frese C, Wohlrab T, Sheng L, Kieser M, Krisam J, Wolff D. Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study. Sci Rep 2019;9(1):7681. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tin and Canagliflozin, Metformin Together: Common Questions

Is it safe to take Tin with Canagliflozin, Metformin?
We do not list a known interaction between Tin and Canagliflozin, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tin and Canagliflozin, Metformin have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Tin and Canagliflozin, Metformin at the same time of day?
At least one FDA label for a product containing Canagliflozin, Metformin says to take it with food. If you take Tin on an empty stomach out of habit, keep them separate and take Canagliflozin, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Canagliflozin, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Canagliflozin, Metformin interact with any supplements?
Yes. Canagliflozin, Metformin has documented interactions with 257 supplements in our database — Tin is not one of them. The Canagliflozin, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tin monograph Uses, safety profile, and every drug interaction in one place Canagliflozin, Metformin supplement interactions Every supplement checked against Canagliflozin, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Canagliflozin, Metformin and Tin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.