Drug & supplement interaction

Trendione + Teplizumab-mzwv

Teplizumab-mzwv brand name: Tzield.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Trendione and Teplizumab-mzwv in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Trendione and Teplizumab-mzwv

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Teplizumab-mzwv and Trendione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Trendione at all — not against Teplizumab-mzwv, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Trendione safety at a glance

Trendione overall Avoid This is a synthetic anabolic steroid with serious safety concerns and no established safe use.
Pregnancy Possibly Unsafe When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Teplizumab-mzwv and Trendione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Teplizumab-mzwv’s Own FDA Label Lists

This is not an interaction — none of it involves Trendione. These are the most notable effects listed in the ADVERSE REACTIONS section of Teplizumab-mzwv’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Blood clots Worth acting on
  • Wheezing Worth acting on
  • A low platelet count Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Chills

Showing the 10 most notable of 21 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Teplizumab-mzwv. Read the label on DailyMed › Trendione’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Trendione side to compare — that is a limit of the record, not a statement that Trendione has no side effects.

Special populations

Trendione in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Teplizumab-mzwv

This page covers Trendione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Teplizumab-mzwv page lists 89 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Active Hexose Correlated Compound (ahcc) (moderate) and Alfalfa (moderate).

By severity: 3 major · 85 moderate · 1 minor.

From our pharmacist’s overview on the Teplizumab-mzwv page

“Siberian cocklebur is the single riskiest item here for anyone on teplizumab-mzwv (Tzield), the infusion given to delay the onset of type 1 diabetes. That herb has caused liver injury and outright liver failure on its own, and 38 of the 89 interacting ingredients on this page share that liver theme, including beer and wine, which carry…”

Reviewed by 2 · Jul 18, 2026

Open the Teplizumab-mzwv interaction page

How much people look this up

Where Trendione and Teplizumab-mzwv Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Trendione
Steady interest

#1,301 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Teplizumab-mzwv
Top half

#1,232 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Trendione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Trendione and Teplizumab-mzwv records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Trendione

What is Trendione?

  • Muscle building
  • Strength gains
  • Body recomposition
  • Athletic performance

Trendione (also marketed as estra-4,9,11-trien-3,17-dione) is a synthetic anabolic steroid sold as a so-called "prohormone" or "designer steroid," not a natural herb or vitamin. It is not a legitimate dietary supplement, has not been proven safe in humans, and is linked to potentially serious side effects, including liver harm. We strongly advise against using it and recommend talking with your doctor or pharmacist.

Not applicable; Trendione is a synthetic steroid compound, not a plant part · Capsules, tablets, oral powders (sold as a bodybuilding supplement)

An interaction check asks whether these two react with each other — it does not ask whether Trendione is a good idea for someone in your situation. Here is what our Trendione record says about it on its own.

Trendione: dosing

There is no established safe or effective dose for Trendione. Because it is a synthetic steroid rather than a studied medicine, no health authority has set a recommended amount.We do not provide dosing for this product because we do not recommend using it.

From our Trendione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Trendione monograph & all interactions
Medication

About Teplizumab-mzwv injection

What Is Teplizumab-mzwv injection Used For?

Brand name: Tzield

Tzield is used to delay the onset of Stage 3 type 1 diabetes (T1D) in adults and children aged 1 year and older who have Stage 2 T1D. It is also used to delay the decline in the body's own insulin production in children and teenagers aged 8 to 17 years who were recently diagnosed with Stage 3 T1D.

There is limited evidence of safety and effectiveness in patients aged 45 and older with Stage 2 T1D. Tzield does not work for blood sugar problems that are not caused by an autoimmune process — it is not effective in non-autoimmune conditions that cause abnormal blood sugar.

See full Teplizumab-mzwv injection drug information
Keep checking

Other Drugs & Trendione

Browse every other medication we’ve checked against Trendione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Trendione against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Trendione list.

See the full Trendione interactions page
See every supplement checked against Teplizumab-mzwv, ranked by severity
Evidence & sources

Trendione References

The 1 references that drive our Trendione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Trendione and Teplizumab-mzwv Together: Common Questions

Is it safe to take Trendione with Teplizumab-mzwv?
We do not list a known interaction between Trendione and Teplizumab-mzwv. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Teplizumab-mzwv interact with any supplements?
Yes. Teplizumab-mzwv has documented interactions with 89 supplements in our database — Trendione is not one of them. The Teplizumab-mzwv interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Trendione monograph Uses, safety profile, and every drug interaction in one place Teplizumab-mzwv injection drug information The full plain-English guide to this medication Teplizumab-mzwv supplement interactions Every supplement checked against Teplizumab-mzwv, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Teplizumab-mzwv and Trendione?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.