Drug & supplement interaction

Vitamin O + Modafinil

Modafinil brand names: Provigil, Sparlon, Alertec.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Vitamin O and Modafinil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Vitamin O and Modafinil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Modafinil and Vitamin O in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Vitamin O at all — not against Modafinil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vitamin O safety at a glance

Vitamin O overall Use caution Products sold as 'Vitamin O' have unproven claims and their ingredients vary, so quality and safety are uncertain.
Pregnancy Avoid There is no safety data, so avoid during pregnancy.
Breastfeeding Avoid There is no safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Modafinil and Vitamin O? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Modafinil’s Own FDA Label Lists

This is not an interaction — none of it involves Vitamin O. These are the most notable effects listed in the ADVERSE REACTIONS section of Modafinil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on
  • Drowsiness mentioned in 4.4% of FDA reports for Modafinil
  • A stuffy or runny nose
  • Anxiety or restlessness mentioned in 4.7% of FDA reports for Modafinil
  • Back pain
  • Trouble sleeping
  • Stomach upset
  • Dizziness
  • Headache mentioned in 5.8% of FDA reports for Modafinil
  • Nausea mentioned in 7.0% of FDA reports for Modafinil

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Modafinil. Read the label on DailyMed › Where a percentage is shown, it is the share of 32,106 voluntary FDA FAERS reports for Modafinil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Vitamin O’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Vitamin O side to compare — that is a limit of the record, not a statement that Vitamin O has no side effects.

Everything else you take

See Every Supplement That Interacts With Modafinil

This page covers Vitamin O only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Modafinil page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (major), Ephedra (major), Grapefruit (major) and Peyote (major).

By severity: 8 major · 150 moderate · 39 minor.

From our pharmacist’s overview on the Modafinil page

“Of the 197 supplements and herbs flagged for modafinil (Provigil, Alertec), eight carry a major rating, and those deserve real caution. Most of the rest fall into two themes.”

Reviewed by 2 · Jul 18, 2026

Open the Modafinil interaction page

How much people look this up

Where Vitamin O and Modafinil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin O
Steady interest

#1,140 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Modafinil
Top half

#846 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Vitamin O is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin O reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Vitamin O and Modafinil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vitamin O

What is Vitamin O?

  • Claimed to add 'stabilized oxygen' to the body
  • General energy and wellness
  • Marketed for improved breathing or vitality

"Vitamin O" is not a real vitamin. It is a marketing name used for liquid products typically containing saltwater (a saline solution) sold with claims of providing 'stabilized oxygen' to the body. There is no credible scientific evidence that these products work, and U.S. regulators have taken action against false advertising for them, so they are best avoided.

Not applicable (manufactured liquid product) · Liquid drops

An interaction check asks whether these two react with each other — it does not ask whether Vitamin O is a good idea for someone in your situation. Here is what our Vitamin O record says about it on its own.

Vitamin O: dosing

There is no established or recommended dose for Vitamin O because it is not a recognized nutrient and has no proven benefit. Different brands give different directions, usually a set number of drops in water.Since the product is unproven, the most cautious advice is to avoid it.

From our Vitamin O monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vitamin O monograph & all interactions
Medication

About Modafinil

What Is Modafinil Used For?

Brand names: Provigil, Sparlon, Alertec

Modafinil (also sold as Provigil) is used to improve wakefulness in adults who experience excessive sleepiness due to narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD).

In OSA, modafinil treats the sleepiness — not the underlying airway obstruction itself. It is used alongside standard treatments such as CPAP (a breathing device worn during sleep), not as a replacement for them. If CPAP is appropriate for you, your doctor will want you to use it consistently even while taking modafinil.

Most-Reported Side Effects for Modafinil

From FAERS, the FDA’s public side-effect reporting system (32,106 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,949 reports
Nausea 2,248 reports
Headache 1,870 reports
Fall 1,794 reports
Depression 1,619 reports
See full Modafinil drug information
Keep checking

Other Drugs & Vitamin O

Browse every other medication we’ve checked against Vitamin O — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Vitamin O against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Vitamin O list.

See the full Vitamin O interactions page
See every supplement checked against Modafinil, ranked by severity
Evidence & sources

Vitamin O References

The 2 sources that drive our Vitamin O monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Vitamin O is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Dietary and Herbal Supplements — NIH National Center for Complementary and Integrative Health Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vitamin O and Modafinil Together: Common Questions

Is it safe to take Vitamin O with Modafinil?
We do not list a known interaction between Vitamin O and Modafinil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Modafinil interact with any supplements?
Yes. Modafinil has documented interactions with 197 supplements in our database — Vitamin O is not one of them. The Modafinil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Vitamin O monograph Uses, safety profile, and every drug interaction in one place Modafinil drug information The full plain-English guide to this medication Modafinil supplement interactions Every supplement checked against Modafinil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Modafinil and Vitamin O?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.