Drug & supplement interaction

Water Hemlock + Penicillamine

Penicillamine brand names: Cuprimine, Depen Titratable.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Water Hemlock and Penicillamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Penicillamine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Water Hemlock and Penicillamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Penicillamine and Water Hemlock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Water Hemlock safety at a glance

Water Hemlock overall Avoid Water hemlock is deadly poisonous and should never be consumed.
Pregnancy Unsafe When used orally or topically. Water hemlock is toxic; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally or topically. Water hemlock is toxic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Penicillamine and Water Hemlock? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Penicillamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Penicillamine is filed under 3 classifications — including nephrotoxic drugs, oral drugs. Water Hemlock has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Penicillamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Water Hemlock Does Interact With Other Medications

Water Hemlock has 1 moderate known drug interaction in our database — Penicillamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Penicillamine)
Taking anything else?

Check Another of Your Medications Against Water Hemlock

Covers the 2,830 medications we’ve checked against Water Hemlock. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Water Hemlock and Penicillamine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    Water Hemlock

    “Water hemlock is a known highly toxic plant and causes a variety of symptoms including vomiting, acute renal failure, marked metabolic acidosis, seizures and convulsions, or unconsciousness that may lead to death.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
    2. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    3. 6351. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
    4. 6348. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
    5. 6346. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
    6. 85535. Landers, D., Seppi, K., and Blauer, W. Seizures and death on a white river float trip. Report of water hemlock poisoning. West J.Med. 1985;142(5):637-640. DOI

    “According to case reports, oral ingestion may cause an explosive illness with rhabdomyolysis, marked metabolic acidosis, or acute renal failure.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.

    4 sources cited
    1. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    2. 6351. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
    3. 6348. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
    4. 6346. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed ›

  • Nausea reported in 10.5% of FDA reports for Penicillamine Additional detail

    Water Hemlock

    “According to case reports, oral ingestion causes an explosive illness with nausea, vomiting, or abdominal cramps.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Vomiting Additional detail

    Water Hemlock

    Recorded for Water Hemlock in the same Natural Medicines adverse-effect record shown under Kidney problems above.

    Penicillamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Penicillamine. Read the label on DailyMed ›

Reported for Water Hemlock but not commonly for Penicillamine: low blood pressure, stomach pain, severe muscle breakdown and seizures.

Effects for Penicillamine come from the ADVERSE REACTIONS section of its FDA label; effects for Water Hemlock come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 917 voluntary FDA FAERS reports for Penicillamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Water Hemlock in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally or topically. Water hemlock is toxic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Penicillamine Products Have a Food Rule — Water Hemlock Should Not Break It

At least one FDA label for a product containing Penicillamine says to take it on an empty stomach. Most supplements — Water Hemlock included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Penicillamine on its own and move Water Hemlock to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Penicillamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION In all patients receiving penicillamine, it is important that CUPRIMINE be given on an empty stomach, at least one hour before meals or two hours after meals, and at least one hour apart from any other drug, food, or milk.

From the Dosage and Administration section of the FDA label we read for Penicillamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Penicillamine

This page covers Water Hemlock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Penicillamine page lists 26 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Coffee Charcoal (moderate).

By severity: 3 major · 13 moderate · 10 minor.

From our pharmacist’s overview on the Penicillamine page

“People take penicillamine (Cuprimine, Depen) for demanding conditions, Wilson's disease, rheumatoid arthritis, cystinuria, and its 26 supplement interactions are not a list to skim, three of them rated major. Seventeen ingredients can keep an oral dose from being fully absorbed, activated charcoal chief among them, and six more can str…”

Reviewed by 2 · Jul 18, 2026

Open the Penicillamine interaction page

How much people look this up

Where Water Hemlock and Penicillamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Water Hemlock
Top half

#551 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Penicillamine
Steady interest

#2,598 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Water Hemlock reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Water Hemlock and Penicillamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Water Hemlock

What is Water Hemlock?

  • Historically misused in folk practice (not recommended)
  • Sometimes confused with edible wild carrots or parsnips
  • No safe medicinal use

Water hemlock is one of the most poisonous plants in North America and is NOT a safe dietary supplement or herbal remedy. Even small amounts can cause violent seizures and death. Never eat, brew, or take any part of this plant, and seek emergency care immediately if exposure is suspected.

Cicuta maculata · Apiaceae · None — this is a toxic plant, not a usable supplement (roots are the most poisonous part) · Not used as a supplement; sometimes mistaken for edible wild plants

An interaction check asks whether these two react with each other — it does not ask whether Water Hemlock is a good idea for someone in your situation. Here is what our Water Hemlock record says about it on its own.

Water Hemlock: dosing

There is no safe dose of water hemlock. The only appropriate action with this plant is avoidance and, in case of exposure, emergency care.

From our Water Hemlock monograph — the full record covers uses, side effects and every documented interaction.

Read the full Water Hemlock monograph & all interactions
Medication

About Penicillamine

What Is Penicillamine Used For?

Brand names: Cuprimine, Depen Titratable

Penicillamine is used for three distinct conditions. It treats Wilson's disease — a rare genetic disorder in which the body accumulates dangerous levels of copper — by binding to the excess copper and helping the body remove it. It also treats cystinuria, a condition where the amino acid cystine builds up and forms painful kidney stones, by converting cystine into a more soluble form that the body can excrete more easily.

For patients with severe, active rheumatoid arthritis who have not responded adequately to conventional therapies, penicillamine (available as Aagylur, Cuprimine, Depen, and other products) may be used to help suppress disease activity and reduce joint pain, tenderness, and swelling.

See full Penicillamine drug information
Keep checking

Other Drugs & Water Hemlock

Browse every other medication we’ve checked against Water Hemlock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Water Hemlock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Water Hemlock list.

See the full Water Hemlock interactions page
See every supplement checked against Penicillamine, ranked by severity
Evidence & sources

Water Hemlock References

The 8 references that drive our Water Hemlock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
  2. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
  3. Anon. Water hemlock poisoning - Maine, 1992. MMWR Morb Mortal Wkly Rep 1994;43:229-31. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/00026056.htm.
  4. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
  5. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
  6. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
  7. Heath, K. B. A fatal case of apparent water hemlock poisoning. Vet.Hum.Toxicol. 2001;43(1):35-36.
  8. Landers, D., Seppi, K., and Blauer, W. Seizures and death on a white river float trip. Report of water hemlock poisoning. West J.Med. 1985;142(5):637-640. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Water Hemlock and Penicillamine Together: Common Questions

Is it safe to take Water Hemlock with Penicillamine?
We do not list a known interaction between Water Hemlock and Penicillamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Water Hemlock and Penicillamine have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Water Hemlock and Penicillamine at the same time of day?
At least one FDA label for a product containing Penicillamine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Penicillamine on its own and move Water Hemlock to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Water Hemlock and Penicillamine combination checked?
Interactions in our licensed database are recorded against drug classes. Penicillamine is filed under 3 classifications, and Water Hemlock has documented interactions with 1 drug class — none of Penicillamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Water Hemlock interact with any other medications?
Yes. Water Hemlock has 1 documented drug interaction in our database — Penicillamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Penicillamine interact with any supplements?
Yes. Penicillamine has documented interactions with 26 supplements in our database — Water Hemlock is not one of them. The Penicillamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Water Hemlock monograph Uses, safety profile, and every drug interaction in one place Penicillamine drug information The full plain-English guide to this medication Penicillamine supplement interactions Every supplement checked against Penicillamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Penicillamine and Water Hemlock?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.