Drug & supplement interaction

Water Hemlock + Apixaban

Apixaban brand name: Eliquis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Water Hemlock and Apixaban in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Water Hemlock and Apixaban

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Apixaban and Water Hemlock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Water Hemlock safety at a glance

Water Hemlock overall Avoid Water hemlock is deadly poisonous and should never be consumed.
Pregnancy Unsafe When used orally or topically. Water hemlock is toxic; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally or topically. Water hemlock is toxic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Apixaban and Water Hemlock? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Apixaban

Interactions in our licensed database are recorded against drug classes, not just single drug names. Apixaban is filed under 4 classifications — including anticoagulant/antiplatelet drugs, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Water Hemlock has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Apixaban’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Water Hemlock Does Interact With Other Medications

Water Hemlock has 1 moderate known drug interaction in our database — Apixaban isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Apixaban)
Taking anything else?

Check Another of Your Medications Against Water Hemlock

Covers the 2,830 medications we’ve checked against Water Hemlock. Pick one to open its full report.

What to actually watch for

What Water Hemlock Itself Has Been Linked To

This is not an interaction — nothing below involves Apixaban. It is the side-effect record for Water Hemlock on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Water Hemlock, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    “According to case reports, oral ingestion may cause an explosive illness with rhabdomyolysis.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.

    2 sources cited
    1. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    2. 6351. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed

    “According to case reports, oral ingestion may cause an explosive illness with rhabdomyolysis, marked metabolic acidosis, or acute renal failure.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.

    4 sources cited
    1. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    2. 6351. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
    3. 6348. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
    4. 6346. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
  • Seizures Worth acting on Additional detail

    “Water hemlock is a known highly toxic plant and causes a variety of symptoms including vomiting, acute renal failure, marked metabolic acidosis, seizures and convulsions, or unconsciousness that may lead to death.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
    2. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    3. 6351. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
    4. 6348. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
    5. 6346. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
    6. 85535. Landers, D., Seppi, K., and Blauer, W. Seizures and death on a white river float trip. Report of water hemlock poisoning. West J.Med. 1985;142(5):637-640. DOI

    “According to case reports, oral ingestion may cause an explosive illness with seizures and convulsions, neurologic lethargy, or unconsciousness that may lead to death.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    2. 85535. Landers, D., Seppi, K., and Blauer, W. Seizures and death on a white river float trip. Report of water hemlock poisoning. West J.Med. 1985;142(5):637-640. DOI
    3. 6348. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
    4. 6346. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
    5. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
    6. 85531. Heath, K. B. A fatal case of apparent water hemlock poisoning. Vet.Hum.Toxicol. 2001;43(1):35-36.
  • Kidney problems Worth acting on Additional detail

    Recorded for Water Hemlock in the same Natural Medicines adverse-effect record shown under Seizures above.

  • A fast or pounding heartbeat / Low blood pressure Additional detail

    “According to case reports, oral ingestion may cause an explosive illness with orthostatic hypotension or tachycardia.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
  • Stomach pain / Nausea Additional detail

    “According to case reports, oral ingestion causes an explosive illness with nausea, vomiting, or abdominal cramps.”

    Water Hemlock · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 6350. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
  • Tiredness Additional detail

    Recorded for Water Hemlock in the same Natural Medicines adverse-effect record shown under Seizures above.

  • Vomiting Additional detail

    Recorded for Water Hemlock in the same Natural Medicines adverse-effect record shown under Seizures above.

Everything above comes from the Natural Medicines adverse-effect record for Water Hemlock — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Apixaban’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Apixaban column appears here.

Special populations

Water Hemlock in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally or topically. Water hemlock is toxic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Water Hemlock or Apixaban

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Water Hemlock or Apixaban, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Apixaban

This page covers Water Hemlock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apixaban page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 240 moderate · 40 minor.

From our pharmacist’s overview on the Apixaban page

“St. John's wort can weaken apixaban (Eliquis), speeding how the body clears this blood thinner and leaving you less protected from the strokes and clots it is prescribed to prevent.”

Reviewed by 2 · Jul 18, 2026

Open the Apixaban interaction page

How much people look this up

Where Water Hemlock and Apixaban Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Water Hemlock
Top half

#597 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Apixaban
Most looked up

#1 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Water Hemlock reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Water Hemlock and Apixaban records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Water Hemlock

What is Water Hemlock?

  • Historically misused in folk practice (not recommended)
  • Sometimes confused with edible wild carrots or parsnips
  • No safe medicinal use

Water hemlock is one of the most poisonous plants in North America and is NOT a safe dietary supplement or herbal remedy. Even small amounts can cause violent seizures and death. Never eat, brew, or take any part of this plant, and seek emergency care immediately if exposure is suspected.

Cicuta maculata · Apiaceae · None — this is a toxic plant, not a usable supplement (roots are the most poisonous part) · Not used as a supplement; sometimes mistaken for edible wild plants

An interaction check asks whether these two react with each other — it does not ask whether Water Hemlock is a good idea for someone in your situation. Here is what our Water Hemlock record says about it on its own.

Water Hemlock: dosing

There is no safe dose of water hemlock. The only appropriate action with this plant is avoidance and, in case of exposure, emergency care.

From our Water Hemlock monograph — the full record covers uses, side effects and every documented interaction.

Read the full Water Hemlock monograph & all interactions
Medication

About Apixaban

What Is Apixaban Used For?

Brand name: Eliquis

Apixaban is used to reduce the risk of stroke and dangerous clots traveling through the body in adults with nonvalvular atrial fibrillation (an irregular heart rhythm not caused by a heart valve problem). It is also used to prevent deep vein thrombosis (DVT — a blood clot in the leg) in adults after hip or knee replacement surgery, and to treat DVT and pulmonary embolism (PE — a blood clot in the lungs) in adults, including reducing the risk of those clots coming back.

Eliquis (the brand-name tablet and kit) is additionally approved to treat venous thromboembolism (VTE — blood clots in the veins) and reduce the risk of recurrent VTE in pediatric patients from birth and older, after at least 5 days of initial anticoagulant treatment. The generic apixaban tablet carries the adult indications only.

See full Apixaban drug information
Keep checking

Other Drugs & Water Hemlock

Browse every other medication we’ve checked against Water Hemlock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Water Hemlock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Water Hemlock list.

See the full Water Hemlock interactions page
See every supplement checked against Apixaban, ranked by severity
Evidence & sources

Water Hemlock References

The 8 references that drive our Water Hemlock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Starreveld E, Hope E. Cicutoxin poisoning (water hemlock). Neurol 1975;25:730-4. PubMed
  2. Knutsen OH, Paszkowski P. New aspects in the treatment of water hemlock poisoning. J Toxicol Clin Toxicol 1984;22:157-66. PubMed
  3. Anon. Water hemlock poisoning - Maine, 1992. MMWR Morb Mortal Wkly Rep 1994;43:229-31. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/00026056.htm.
  4. Applefeld JJ, Caplan ES. A case of water hemlock poisoning. JACEP 1979;8:401-3. PubMed
  5. Carlton BE, Tufts E, Girard DE. Water hemlock poisoning complicated by rhabdomyolysis and renal failure. Clin Toxicol 1979;14:87-92. PubMed
  6. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
  7. Heath, K. B. A fatal case of apparent water hemlock poisoning. Vet.Hum.Toxicol. 2001;43(1):35-36.
  8. Landers, D., Seppi, K., and Blauer, W. Seizures and death on a white river float trip. Report of water hemlock poisoning. West J.Med. 1985;142(5):637-640. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Water Hemlock and Apixaban Together: Common Questions

Is it safe to take Water Hemlock with Apixaban?
We do not list a known interaction between Water Hemlock and Apixaban. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Water Hemlock and Apixaban combination checked?
Interactions in our licensed database are recorded against drug classes. Apixaban is filed under 4 classifications, and Water Hemlock has documented interactions with 1 drug class — none of Apixaban's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Water Hemlock interact with any other medications?
Yes. Water Hemlock has 1 documented drug interaction in our database — Apixaban is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Apixaban interact with any supplements?
Yes. Apixaban has documented interactions with 285 supplements in our database — Water Hemlock is not one of them. The Apixaban interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Water Hemlock monograph Uses, safety profile, and every drug interaction in one place Apixaban drug information The full plain-English guide to this medication Apixaban supplement interactions Every supplement checked against Apixaban, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Apixaban and Water Hemlock?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.