Wintergreen + Duloxetine

Wintergreen has 2 major, 35 moderate known drug interactions in our database — Duloxetine isn’t one of them. If you take anything else, check it against the full list below.

We haven’t checked that one against Wintergreen yet — ask our pharmacists directly.

Covers the 2,830 medications we’ve checked against Wintergreen. Pick one to open its full report.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

These two come up together because they touch the same health topic — not because they do the same job. Duloxetine is a prescription medicine with approved uses on its FDA label. Wintergreen is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Duloxetine is prescribed for: Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults. GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products.

Wintergreen has been studied for:

• Back pain studied, not established Wintergreen has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Wintergreen for back pain

  Although there has been interest in using topical wintergreen oil for back pain, there is insufficient reliable information about the clinical effects of wintergreen for this purpose.

• Joint pain studied, not established Wintergreen has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Wintergreen for joint pain

  Although there has been interest in using topical wintergreen oil for joint pain, including in those with osteoarthritis or rheumatoid arthritis, there is insufficient reliable information about the clinical effects of wintergreen for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Duloxetine on your own; if you are taking Wintergreen for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wintergreen or Duloxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

• Is It Safe To Take Ignatia Amara (Ignatius Bean) With Cymbalta? Answered by Dr. Brian Staiger, PharmD · June 2025 ›
• Does Cymbalta (Duloxetine) Interact With Berberine? Answered by Dr. Brian Staiger, PharmD · February 2024 ›
• Does Apple Cider Vinegar Interact With Cymbalta? Answered by Dr. Brian Staiger, PharmD · August 2023 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

This page covers Wintergreen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duloxetine page lists 132 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Lithium (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 107 moderate · 20 minor.

Open the Duloxetine interaction page ›

We hold 42 real supplement products containing Wintergreen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wintergreen. Even though Wintergreen itself has no known interaction with Duloxetine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Natural Medicines records Duloxetine as a medicine that can lower these. This is not an interaction with Wintergreen — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

• SODIUM›

Read the full Duloxetine nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.