Witch Hazel + Enfortumab Vedotin-Ejfv
Enfortumab Vedotin-Ejfv brand name: Padcev.
We found no known interaction between Witch Hazel and Enfortumab Vedotin-Ejfv in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Witch Hazel and Enfortumab Vedotin-Ejfv
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Enfortumab Vedotin-Ejfv and Witch Hazel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Witch Hazel at all — not against Enfortumab Vedotin-Ejfv, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Witch Hazel safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Enfortumab Vedotin-Ejfv Is Prescribed For, and What Witch Hazel Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Enfortumab Vedotin-Ejfv is a prescription medicine with approved uses on its FDA label. Witch Hazel is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Witch Hazel has been studied for:
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Cancer studied, not established Witch Hazel has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Witch Hazel for cancer
Although there has been interest in using oral and topical witch hazel for cancer, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Enfortumab Vedotin-Ejfv on your own; if you are taking Witch Hazel for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Enfortumab Vedotin-Ejfv
This page covers Witch Hazel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enfortumab Vedotin-Ejfv page lists 121 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).
By severity: 2 major · 87 moderate · 32 minor.
From our pharmacist’s overview on the Enfortumab Vedotin-Ejfv page
“If you are getting Padcev (enfortumab vedotin) infusions for bladder cancer, treat this page as one worth genuine attention. The chemotherapy payload in Padcev is cleared by a liver enzyme called CYP3A4, and all 121 ingredients listed here act on that enzyme, either blocking it so the drug builds up or speeding it up so treatment weakens.”
Reviewed by 2 · Jul 18, 2026
Taking Witch Hazel as Part of a Dietary Supplement Product? Check It for Interactions
We hold 150 real supplement products containing Witch Hazel, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Witch Hazel. Even though Witch Hazel itself has no known interaction with Enfortumab Vedotin-Ejfv, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Witch Hazel and Enfortumab Vedotin-Ejfv Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,049 of 1,452 supplements looked up here in the last 7 days
#586 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Witch Hazel reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Witch Hazel and Enfortumab Vedotin-Ejfv records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Witch Hazel
What is Witch Hazel?
- Skin irritation and inflammation
- Hemorrhoids
- Minor cuts and bruises
- Oily or acne-prone skin
- Itching and minor swelling
- Soothing after shaving or sun exposure
Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a topical product for short-term use, but evidence for most uses is limited, and it should not be swallowed. Check with your pharmacist or doctor before using it, especially during pregnancy or breastfeeding.
Hamamelis virginiana · Hamamelidaceae · Bark, leaves, and twigs · Liquid astringent (distilled water), gels, ointments, creams, wipes/pads, suppositories, soaps
An interaction check asks whether these two react with each other — it does not ask whether Witch Hazel is a good idea for someone in your situation. Here is what our Witch Hazel record says about it on its own.
Witch Hazel: dosing
There is no official standardized dose for witch hazel. The right amount depends on the product and the form, such as a liquid, gel, pad, or ointment.The safest approach is to follow the directions on the product label and use it only on the skin as directed. For hemorrhoid pads or creams, follow the package instructions. Do not take witch hazel by mouth unless a healthcare professional specifically advises it.
From our Witch Hazel monograph — the full record covers uses, side effects and every documented interaction.
About Enfortumab vedotin-ejfv Injection
What Is Enfortumab vedotin-ejfv Injection Used For?
Brand name: Padcev
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Enfortumab vedotin-ejfv injection is used to treat urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread to nearby tissues or other parts of the body or cannot be removed by surgery, and has worsened after treatment with other chemotherapy medications or if these chemotherapy medications cannot be used for treatment. Enfortumab vedotin-ejfv injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.
Other Drugs & Witch Hazel
Browse every other medication we’ve checked against Witch Hazel — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Witch Hazel against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Witch Hazel list.
Witch Hazel References
The 7 references that drive our Witch Hazel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948. PubMed
- Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410. PubMed
- Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201 PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Witch Hazel and Enfortumab Vedotin-Ejfv Together: Common Questions
Is it safe to take Witch Hazel with Enfortumab Vedotin-Ejfv?
Are Witch Hazel and Enfortumab Vedotin-Ejfv used for the same thing?
Does Enfortumab Vedotin-Ejfv interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.