Medication interaction hub

What Supplements Interact with Enfortumab Vedotin-Ejfv?

Enfortumab Vedotin-Ejfv brand name: Padcev. Every interaction below applies to the brands too.

121 Interactions 2 Major 87 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Enfortumab Vedotin-Ejfv? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Enfortumab Vedotin-Ejfv against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you are getting Padcev (enfortumab vedotin) infusions for bladder cancer, treat this page as one worth genuine attention. The chemotherapy payload in Padcev is cleared by a liver enzyme called CYP3A4, and all 121 ingredients listed here act on that enzyme, either blocking it so the drug builds up or speeding it up so treatment weakens. Two are rated major: grapefruit, which reliably raises levels of drugs cleared this way, and St. John's wort, which does the opposite and can quietly undercut the therapy itself.

The other 87 moderate and 32 minor entries push on the same enzyme with thinner evidence, often lab studies only, so I would run each one past your oncology pharmacist rather than guess. The risk cuts both ways with a cancer infusion, since too much drug means harsher nerve, skin, and blood sugar side effects, while too little means less pressure on the cancer itself.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 87 Minor 32 No known interaction 1,331

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Enfortumab Vedotin-Ejfv: Top Interactions at a Glance

The Enfortumab Vedotin-Ejfv supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 121 interacting ingredients — plus 1,331 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Enfortumab Vedotin-Ejfv Combinations Today

The Enfortumab Vedotin-Ejfv + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Astaxanthin + Enfortumab Vedotin-Ejfvi

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Sweet Annie + Enfortumab Vedotin-Ejfvi

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Kratom + Enfortumab Vedotin-Ejfvi

Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Milk Thistle + Enfortumab Vedotin-Ejfvi

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Read the full interaction Major Likelihood Likely Grapefruit + Enfortumab Vedotin-Ejfvi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable St. John's Wort + Enfortumab Vedotin-Ejfvi

St.

Read the full interaction
The complete list

Every Supplement Checked Against Enfortumab Vedotin-Ejfv

All 1,452 ingredients in our database, ranked by severity — 121 with a Enfortumab Vedotin-Ejfv interaction on file and 1,331 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Enfortumab Vedotin-Ejfv?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Astaxanthin with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Enfortumab Vedotin-Ejfv answer

Can you take Sweet Annie with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.

Full Sweet Annie + Enfortumab Vedotin-Ejfv answer

Can you take Kratom with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Enfortumab Vedotin-Ejfv answer

Can you take Milk Thistle with Enfortumab Vedotin-Ejfv?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Enfortumab Vedotin-Ejfv answer

Can you take Black Pepper with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Enfortumab Vedotin-Ejfv answer

Can you take Bog Labrador Tea with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Enfortumab Vedotin-Ejfv answer

Can you take Boswellia Serrata with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Enfortumab Vedotin-Ejfv answer

Can you take Bulbine Natalensis with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Enfortumab Vedotin-Ejfv answer

Can you take Calamus with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Enfortumab Vedotin-Ejfv answer

Can you take Cannabis with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Enfortumab Vedotin-Ejfv answer

Can you take Cat's Claw with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Enfortumab Vedotin-Ejfv answer

Can you take Ceylon Leadwort with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Enfortumab Vedotin-Ejfv answer

Can you take Chanca Piedra with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Enfortumab Vedotin-Ejfv answer

Can you take Chokeberry with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Enfortumab Vedotin-Ejfv answer

Can you take Clove with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Enfortumab Vedotin-Ejfv answer

Can you take Coleus with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Enfortumab Vedotin-Ejfv answer

Can you take Corydalis Yanhusuo with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Enfortumab Vedotin-Ejfv answer

Can you take Cranberry with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Enfortumab Vedotin-Ejfv answer

Can you take Cubebs with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Enfortumab Vedotin-Ejfv answer

Can you take Danshen with Enfortumab Vedotin-Ejfv?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Enfortumab Vedotin-Ejfv answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Enfortumab Vedotin-Ejfv is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Enfortumab Vedotin-Ejfv, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Enfortumab Vedotin-Ejfv sits in 1 interaction category. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Enfortumab Vedotin-Ejfv through this category.

About Enfortumab Vedotin-Ejfv

Enfortumab Vedotin-Ejfv is a prescription medication also sold under the brand name Padcev. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Enfortumab Vedotin-Ejfv  ·  Brand name: Padcev.

See the full Enfortumab vedotin-ejfv Injection drug information
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Take a Supplement Product? Check the Whole Bottle Against Enfortumab Vedotin-Ejfv

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Enfortumab Vedotin-Ejfv.

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Pharmacist Counseling Corner

Enfortumab Vedotin-Ejfv & Supplements: Common Questions

What supplements interact with Enfortumab Vedotin-Ejfv?
In our interaction database, 121 supplement and herbal ingredients have an interaction with Enfortumab Vedotin-Ejfv on file — 2 rated major, 87 moderate, and 32 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Enfortumab Vedotin-Ejfv supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Enfortumab Vedotin-Ejfv?
That depends entirely on which supplement. The honest answer for Enfortumab Vedotin-Ejfv is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Padcev have the same supplement interactions as Enfortumab Vedotin-Ejfv?
Yes — Padcev all contain Enfortumab Vedotin-Ejfv, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Enfortumab Vedotin-Ejfv and my other medications?
This page covers Enfortumab Vedotin-Ejfv against supplements and herbal ingredients. Checking Enfortumab Vedotin-Ejfv against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Enfortumab vedotin-ejfv Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.