Drug & supplement interaction

Blessed Thistle + Enfortumab Vedotin-Ejfv

Enfortumab Vedotin-Ejfv brand name: Padcev.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Blessed Thistle and Enfortumab Vedotin-Ejfv in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Blessed Thistle and Enfortumab Vedotin-Ejfv

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Enfortumab Vedotin-Ejfv and Blessed Thistle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blessed Thistle safety at a glance

Blessed Thistle overall Use caution Often well tolerated in small amounts, but human safety data are limited and large doses can cause nausea or vomiting.

Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail

Breastfeeding Use caution Used traditionally to support milk supply, but safety has not been well studied, so check with your doctor first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Enfortumab Vedotin-Ejfv and Blessed Thistle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Enfortumab Vedotin-Ejfv

Interactions in our licensed database are recorded against drug classes, not just single drug names. Enfortumab Vedotin-Ejfv is filed under a single classification — cytochrome p450 3a4 (cyp3a4) substrates. Blessed Thistle has documented interactions with 3 drug classes — the most serious being antacids (minor), h2-blockers (minor) and proton pump inhibitors (ppis) (minor) — and none of Enfortumab Vedotin-Ejfv’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Blessed Thistle Does Interact With Other Medications

Blessed Thistle has 36 minor known drug interactions in our database — Enfortumab Vedotin-Ejfv isn’t one of them. If you take anything else, check it against the full list below.

Minor 36 No known interaction 2,794 (incl. Enfortumab Vedotin-Ejfv)

Taking anything else?

Check Another of Your Medications Against Blessed Thistle

Covers the 2,830 medications we’ve checked against Blessed Thistle. Pick one to open its full report.

What to actually watch for

What Blessed Thistle Itself Has Been Linked To

This is not an interaction — nothing below involves Enfortumab Vedotin-Ejfv. It is the side-effect record for Blessed Thistle on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Blessed Thistle, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

An allergic reaction Worth acting on Additional detail
“Topically, blessed thistle can cause an allergic reaction, such as dermatitis, in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs (12).”

Blessed Thistle · Natural Medicines adverse-effect record, reported in dermatitis.
1 source cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Stomach upset / Vomiting Additional detail
“Orally, when blessed thistle is used in doses higher than 5 grams per cup of tea, it can cause stomach irritation and vomiting (12).”

Blessed Thistle · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
A skin rash Additional detail

Recorded for Blessed Thistle in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Blessed Thistle — expand a row for the licensed statement it rests on. We haven’t matched Enfortumab Vedotin-Ejfv to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Enfortumab Vedotin-Ejfv.

Special populations

Blessed Thistle in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Enfortumab Vedotin-Ejfv

This page covers Blessed Thistle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enfortumab Vedotin-Ejfv page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Enfortumab Vedotin-Ejfv page

“If you are getting Padcev (enfortumab vedotin) infusions for bladder cancer, treat this page as one worth genuine attention. The chemotherapy payload in Padcev is cleared by a liver enzyme called CYP3A4, and all 121 ingredients listed here act on that enzyme, either blocking it so the drug builds up or speeding it up so treatment weakens.”

Reviewed by 2 · Jul 18, 2026

Open the Enfortumab Vedotin-Ejfv interaction page

One more smart check

Taking Blessed Thistle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 729 real supplement products containing Blessed Thistle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blessed Thistle. Even though Blessed Thistle itself has no known interaction with Enfortumab Vedotin-Ejfv, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blessed Thistle and Enfortumab Vedotin-Ejfv Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blessed Thistle

Top 25%

#312 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Enfortumab Vedotin-Ejfv

Top 25%

#586 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blessed Thistle reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Blessed Thistle and Enfortumab Vedotin-Ejfv records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Blessed Thistle

What is Blessed Thistle?

Digestive upset and poor appetite
Boosting bile flow
General bitter tonic
Supporting milk supply during breastfeeding (traditional)
Wound care (traditional, topical)

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It is likely fine for short-term use in small, food-like amounts, but it should be avoided in pregnancy and used with caution by people allergic to ragweed and related plants.

Cnicus benedictus · Asteraceae · Aerial parts (leaves, stems, and flowers) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Blessed Thistle is a good idea for someone in your situation. Here is what our Blessed Thistle record says about it on its own.

Blessed Thistle: dosing

There is no official, standardized dose of blessed thistle. The right amount can vary depending on the product and the form (tea, tincture, or capsules).The best approach is to follow the directions on the product label and not exceed the recommended amount, since large doses are more likely to cause nausea and vomiting.

From our Blessed Thistle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blessed Thistle monograph & all interactions

Medication

About Enfortumab vedotin-ejfv Injection

What Is Enfortumab vedotin-ejfv Injection Used For?

Brand name: Padcev

Enfortumab vedotin-ejfv injection is used to treat urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread to nearby tissues or other parts of the body or cannot be removed by surgery, and has worsened after treatment with other chemotherapy medications or if these chemotherapy medications cannot be used for treatment. Enfortumab vedotin-ejfv injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

See full Enfortumab vedotin-ejfv Injection drug information

Keep checking

Other Drugs & Blessed Thistle

Browse every other medication we’ve checked against Blessed Thistle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

36Minor

2,793No known interaction

36 Minor 2,793 No interaction

Minor

36 interactions

No interaction 2,793 drugs checked — show the list

We also checked Blessed Thistle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,793 medications checked with no known interaction — see the full Blessed Thistle list.

See the full Blessed Thistle interactions page

See every supplement checked against Enfortumab Vedotin-Ejfv, ranked by severity

Evidence & sources

Blessed Thistle References

The 2 references that drive our Blessed Thistle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Blessed Thistle and Enfortumab Vedotin-Ejfv Together: Common Questions

Is it safe to take Blessed Thistle with Enfortumab Vedotin-Ejfv?

We do not list a known interaction between Blessed Thistle and Enfortumab Vedotin-Ejfv. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Blessed Thistle and Enfortumab Vedotin-Ejfv combination checked?

Interactions in our licensed database are recorded against drug classes. Enfortumab Vedotin-Ejfv is filed under 1 classification, and Blessed Thistle has documented interactions with 3 drug classes — none of Enfortumab Vedotin-Ejfv's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Blessed Thistle interact with any other medications?

Yes. Blessed Thistle has 36 documented drug interactions in our database — Enfortumab Vedotin-Ejfv is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Enfortumab Vedotin-Ejfv interact with any supplements?

Yes. Enfortumab Vedotin-Ejfv has documented interactions with 121 supplements in our database — Blessed Thistle is not one of them. The Enfortumab Vedotin-Ejfv interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blessed Thistle monograph Uses, safety profile, and every drug interaction in one place Enfortumab vedotin-ejfv Injection drug information The full plain-English guide to this medication Enfortumab Vedotin-Ejfv supplement interactions Every supplement checked against Enfortumab Vedotin-Ejfv, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Enfortumab Vedotin-Ejfv and Blessed Thistle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.