Drug & supplement interaction

Eryngo + Enfortumab Vedotin-Ejfv

Enfortumab Vedotin-Ejfv brand name: Padcev.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Eryngo and Enfortumab Vedotin-Ejfv in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Eryngo and Enfortumab Vedotin-Ejfv

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Enfortumab Vedotin-Ejfv and Eryngo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Eryngo at all — not against Enfortumab Vedotin-Ejfv, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Eryngo safety at a glance

Eryngo overall Use caution Limited safety data exist, so use cautiously and only under guidance.

Pregnancy Avoid Not enough safety information is available, so it is best to avoid use during pregnancy.

Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Enfortumab Vedotin-Ejfv and Eryngo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Eryngo Itself Has Been Linked To

This is not an interaction — nothing below involves Enfortumab Vedotin-Ejfv. It is the side-effect record for Eryngo on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Eryngo, this list is the first place to look.

Vomiting / Nausea Additional detail
“Orally, large doses of eryngo known as button eryngo may cause nausea and vomiting (12). No adverse effects have been reported for other types of eryngo; however, a high-quality assessment of safety has not been conducted.”

Eryngo · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Everything above comes from the Natural Medicines adverse-effect record for Eryngo — expand a row for the licensed statement it rests on. We haven’t matched Enfortumab Vedotin-Ejfv to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Enfortumab Vedotin-Ejfv.

Everything else you take

See Every Supplement That Interacts With Enfortumab Vedotin-Ejfv

This page covers Eryngo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Enfortumab Vedotin-Ejfv page lists 121 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 87 moderate · 32 minor.

From our pharmacist’s overview on the Enfortumab Vedotin-Ejfv page

“If you are getting Padcev (enfortumab vedotin) infusions for bladder cancer, treat this page as one worth genuine attention. The chemotherapy payload in Padcev is cleared by a liver enzyme called CYP3A4, and all 121 ingredients listed here act on that enzyme, either blocking it so the drug builds up or speeding it up so treatment weakens.”

Reviewed by 2 · Jul 18, 2026

Open the Enfortumab Vedotin-Ejfv interaction page

How much people look this up

Where Eryngo and Enfortumab Vedotin-Ejfv Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Eryngo

Steady interest

#942 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Enfortumab Vedotin-Ejfv

Top half

#1,312 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Eryngo reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Eryngo and Enfortumab Vedotin-Ejfv records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Eryngo

What is Eryngo?

Urinary tract complaints
Diuretic (increasing urine flow)
Respiratory infections and cough
Kidney and bladder problems
Menstrual pain

Eryngo is a thistle-like herb traditionally used as a diuretic and for urinary and respiratory complaints, but there is very little human research to confirm it actually works. Because its safety has not been well studied, it should be used cautiously and avoided during pregnancy and breastfeeding. Talk to a pharmacist or doctor before trying it.

Eryngium campestre · Apiaceae · Root and aerial parts (herb) · Tea (infusion or decoction), tincture, dried root, capsules

An interaction check asks whether these two react with each other — it does not ask whether Eryngo is a good idea for someone in your situation. Here is what our Eryngo record says about it on its own.

Eryngo: dosing

There is no well-established or standardized dose for eryngo. Traditional use typically involved a tea (infusion or decoction) made from the dried root or herb, but reliable, science-based dosing has not been determined.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Eryngo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Eryngo monograph & all interactions

Medication

About Enfortumab vedotin-ejfv Injection

What Is Enfortumab vedotin-ejfv Injection Used For?

Brand name: Padcev

Enfortumab vedotin-ejfv injection is used to treat urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread to nearby tissues or other parts of the body or cannot be removed by surgery, and has worsened after treatment with other chemotherapy medications or if these chemotherapy medications cannot be used for treatment. Enfortumab vedotin-ejfv injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

See full Enfortumab vedotin-ejfv Injection drug information

Keep checking

Other Drugs & Eryngo

Browse every other medication we’ve checked against Eryngo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Eryngo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Eryngo list.

See the full Eryngo interactions page

See every supplement checked against Enfortumab Vedotin-Ejfv, ranked by severity

Evidence & sources

Eryngo References

The 2 references that drive our Eryngo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Behmanesh E, Delavar MA, Kamalinejad M, Khafri S, Shirafkan H, Mozaffarpur SA. Effect of eryngo (Eryngium caucasicum Trautv) on primary dysmenorrhea: A randomized, double-blind, placebo-controlled study. Taiwan J Obstet Gynecol. 2019;58(2):227-33. doi: 10 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Eryngo and Enfortumab Vedotin-Ejfv Together: Common Questions

Is it safe to take Eryngo with Enfortumab Vedotin-Ejfv?

We do not list a known interaction between Eryngo and Enfortumab Vedotin-Ejfv. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Enfortumab Vedotin-Ejfv interact with any supplements?

Yes. Enfortumab Vedotin-Ejfv has documented interactions with 121 supplements in our database — Eryngo is not one of them. The Enfortumab Vedotin-Ejfv interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Eryngo monograph Uses, safety profile, and every drug interaction in one place Enfortumab vedotin-ejfv Injection drug information The full plain-English guide to this medication Enfortumab Vedotin-Ejfv supplement interactions Every supplement checked against Enfortumab Vedotin-Ejfv, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Enfortumab Vedotin-Ejfv and Eryngo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.