Xanthan Gum - Zejula (Niraparib Tosylate) Interaction

Interaction Details

Niraparib Tosylate is classified as belonging to the following category: Oral Drugs

Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities. Xanthan gum slows gastric emptying and has been used to control the release of drugs in tablet formulations. To avoid any alterations in drug absorption, xanthan gum should be taken 30-60 minutes after oral medications.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Osilesi O, Trout DL, Glover EE, et al. Use of xanthan gum in dietary management of diabetes mellitus. Am J Clin Nutr 1985;42: 597-603.
• Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20.

Niraparib Tosylate Overview

• Niraparib is used to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the stomach) cancer in people who have completely responded or partially responded to other chemotherapy medication(s). It is also used to treat certain types of ovarian, fallopian tube, or peritoneal cancer when the cancer has gotten worse after 3 or more chemotherapy treatments. Niraparib is in a class of medications called poly (ADP-ribose) polymerase (PARP) inhibitors. It works by killing cancer cells.

Xanthan Gum - More Interactions

Xanthan Gum interacts with 1987 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.