Yew + Sorafenib
Sorafenib brand name: Nexavar.
We found no known interaction between Yew and Sorafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sorafenib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Yew and Sorafenib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sorafenib and Yew in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Yew at all — not against Sorafenib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Yew safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Yew in Pregnancy & Breastfeeding
When the needles are used orally. Yew needles have been used as an abortifacient.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Sorafenib Products Have a Food Rule — Yew Should Not Break It
At least one FDA label for a product containing Sorafenib says to take it on an empty stomach. Most supplements — Yew included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Sorafenib on its own and move Yew to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sorafenib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION The recommended dosage is 400 mg orally twice daily without food.
From the Dosage and Administration section of the FDA label we read for Sorafenib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Sorafenib
This page covers Yew only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sorafenib page lists 285 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).
By severity: 5 major · 241 moderate · 39 minor.
From our pharmacist’s overview on the Sorafenib page
“If you're on sorafenib (Nexavar) for cancer, be genuinely careful here, and learn the five major-rated entries first. Most of the 285 ingredients listed either have blood-thinning effects that stack onto sorafenib's bleeding risk (more than 200 do) or affect CYP3A4, the liver enzyme that clears the drug, pushing its level too high or t…”
Reviewed by 2 · Jul 18, 2026
Taking Yew as Part of a Dietary Supplement Product? Check It for Interactions
We hold 7 real supplement products containing Yew, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yew. Even though Yew itself has no known interaction with Sorafenib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Yew and Sorafenib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,051 of 1,452 supplements looked up here in the last 7 days
#2,213 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yew reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yew and Sorafenib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Yew
What is Yew?
- Source of cancer chemotherapy drugs
- Historical folk and ornamental use
- Traditional remedies (now considered unsafe)
Yew is a highly poisonous plant, and nearly all parts can be deadly even in small amounts. It is famous mainly because pharmaceutical drugs like paclitaxel (Taxol) are made from yew compounds in a controlled lab setting — but yew itself should never be taken as a supplement, tea, or home remedy.
Taxus baccata · Taxaceae · Needles (leaves), bark, and seeds (all highly toxic); semi-synthetic drugs are derived from yew compounds · Not used as a home remedy; yew-derived compounds are used only as prescription chemotherapy drugs (paclitaxel, docetaxel)
An interaction check asks whether these two react with each other — it does not ask whether Yew is a good idea for someone in your situation. Here is what our Yew record says about it on its own.
Yew: dosing
There is no safe dose of yew as a supplement or herbal product. It should never be taken by mouth in any form.The cancer drugs derived from yew (paclitaxel and docetaxel) are completely different products.
From our Yew monograph — the full record covers uses, side effects and every documented interaction.
About Sorafenib
What Is Sorafenib Used For?
Brand name: Nexavar
Sorafenib tablets are approved to treat three types of cancer. The first is unresectable hepatocellular carcinoma (HCC) — liver cancer that cannot be removed with surgery. The second is advanced renal cell carcinoma (RCC) — kidney cancer that has spread or progressed. Both the brand Nexavar and generic sorafenib tablets are approved for these two uses.
The third use is for locally recurrent or metastatic, progressive differentiated thyroid carcinoma (DTC) — thyroid cancer that has spread or worsened and no longer responds to radioactive iodine treatment. Nexavar and sorafenib tablets are both approved for this use as well.
Other Drugs & Yew
Browse every other medication we’ve checked against Yew — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Yew against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Yew list.
Yew References
The 17 references that drive our Yew monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Sinn LE, Porterfield JF. Fatal taxine poisoning from yew leaf ingestion. J Forensic Sci 1991;36:599-601. DOI
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7. PubMed
- Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23. PubMed
- Maguchi, S. and Fukuda, S. Taxus cuspidata (Japanese yew) pollen nasal allergy. Auris Nasus Larynx 2001;28 Suppl:S43-S47. PubMed
- Willaert, W., Claessens, P., Vankelecom, B., and Vanderheyden, M. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing Clin.Electrophysiol. 2002;25(4 Pt 1):511-512.
- Yersin, B., Frey, J. G., Schaller, M. D., Nicod, P., and Perret, C. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann.Emerg.Med. 1987;16(12):1396-1397. PubMed
- de Vos FYFL, van Laarhoven HMW. Taxus baccata allergy in a breast cancer patient. Neth J Med. 2012;70(5):249-0.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41. PubMed
- Pilija V, Djurendic-Brenesel M, Miletic S. Fatal poisoning by ingestion of Taxus Baccata leaves. Forensic Sci Int. 2018;290:e1-e4. PubMed
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987 PubMed
- Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8. PubMed
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709. PubMed
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Yew and Sorafenib Together: Common Questions
Is it safe to take Yew with Sorafenib?
Do Yew and Sorafenib have any of the same side effects?
Should I take Yew and Sorafenib at the same time of day?
Does Sorafenib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.