Zone Diet + Methylnaltrexone
Methylnaltrexone brand name: Relistor.
We found no known interaction between Zone Diet and Methylnaltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Zone Diet and Methylnaltrexone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Methylnaltrexone and Zone Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Zone Diet alongside specific medications may be limited.
Worth understanding: our licensed dataset holds no drug-interaction record for Zone Diet at all — not against Methylnaltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
Zone Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Zone Diet safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Methylnaltrexone
This page covers Zone Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylnaltrexone page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Fever Bark (moderate), Iboga (moderate) and Yohimbe (moderate).
By severity: 3 moderate.
From our pharmacist’s overview on the Methylnaltrexone page
“If you take methylnaltrexone (Relistor) for opioid-induced constipation, the supplement list to know is short: three ingredients, all rated moderate, none major. Yohimbe, fever bark, and iboga are all cleared by the same liver enzyme, CYP2D6, and methylnaltrexone can slow that enzyme, letting their active compounds build up in your blood.”
Reviewed by 2 · Jul 18, 2026
Where Zone Diet and Methylnaltrexone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#951 of 1,452 supplements looked up here in the last 7 days
#2,793 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Zone Diet reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Zone Diet and Methylnaltrexone records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Zone Diet
What is Zone Diet?
- Weight loss
- Blood sugar control
- Reducing inflammation
- Heart health support
- Improving energy and athletic performance
The Zone Diet is an eating plan, not an herb or supplement, that aims to balance every meal into roughly 40% carbohydrate, 30% protein, and 30% fat. It can help some people lose weight and improve diet quality, mostly by encouraging portion control and lean proteins, but evidence that its specific ratio is better than other balanced diets is limited. Talk with your doctor, pharmacist, or a dietitian before starting, especially if you have a medical condition.
Eating plan (whole-food meals and snacks), meal-delivery services, prepackaged bars and shakes
An interaction check asks whether these two react with each other — it does not ask whether Zone Diet is a good idea for someone in your situation. Here is what our Zone Diet record says about it on its own.
Zone Diet: dosing
There is no pill or standardized "dose" for the Zone Diet because it is an eating pattern, not a supplement. Instead, the plan is followed by structuring meals around the 40% carbohydrate, 30% protein, 30% fat idea and eating regular, portion-controlled meals and snacks.If you use Zone-branded products like bars or meals, follow the label directions.
From our Zone Diet monograph — the full record covers uses, side effects and every documented interaction.
About Methylnaltrexone
What Is Methylnaltrexone Used For?
Brand name: Relistor
Methylnaltrexone, sold as Relistor, treats opioid-induced constipation (OIC) — constipation caused by opioid pain medications. Both Relistor tablets and Relistor injection are approved for adults with chronic non-cancer pain, including those with pain related to a prior cancer or its treatment who do not need frequent opioid dose increases.
Relistor injection is also approved for adults with advanced illness or active cancer pain who require increasing opioid doses as part of palliative care.
Other Drugs & Zone Diet
Browse every other medication we’ve checked against Zone Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Zone Diet against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Zone Diet list.
Zone Diet References
The 4 references that drive our Zone Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Fontani, G., Corradeschi, F., Felici, A., Alfatti, F., Bugarini, R., Fiaschi, A. I., Cerretani, D., Montorfano, G., Rizzo, A. M., and Berra, B. Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyu
- Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9) PubMed
- McAuley KA, Hopkins CM, Smith KJ, et al. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia. 2005 Jan;48(1):8-16. Epub 2004 Dec 23. Erratum in: Diabetologia. 2005 May;48(5):1033.
- Jarvis M, McNaughton L, Seddon A, Thompson D. The acute 1-week effects of the Zone diet on body composition, blood lipid levels, and performance in recreational endurance athletes. J Strength Cond Res. 2002 Feb;16(1):50-7. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Following Zone Diet While Taking Methylnaltrexone: Common Questions
Is it safe to follow Zone Diet while taking Methylnaltrexone?
Does Methylnaltrexone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.