Arrowroot Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Arrowroot interacts with medications. The heart of this page is the interaction list — every drug Arrowroot is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Arrowroot is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Arrowroot against your medication
Add one medicationDrugs that interact with Arrowroot
0 medications have a known interaction with Arrowroot, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Arrowroot. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Arrowroot combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Arrowroot: Uses, Safety & Side Effects
Arrowroot is a starch made from the roots of Maranta arundinacea and is mainly used as a gentle, easy-to-digest thickening agent in food. Some people use it for diarrhea and digestive discomfort, but solid human evidence for these health benefits is limited. As a food it is generally well tolerated, but talk with your pharmacist or doctor before using it to treat a medical condition.

- Scientific name
- Maranta arundinacea
- Family
- Marantaceae
- Part used
- Rhizomes (roots), processed into starch
- Common forms
- Powder (starch), flour, capsules, food thickener, cosmetic ingredient
- Diarrhea
- Irritable bowel syndrome (IBS) symptoms
- Digestive upset
- Gluten-free thickener/food ingredient
- Soothing skin and cosmetics
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Arrowroot starch is widely eaten as food and is generally well tolerated in normal amounts.
When used in amounts found in foods. There is insufficient reliable information available about the safety of larger amounts used during pregnancy and...
Read the full pregnancy detailWhen used in amounts found in foods. There is insufficient reliable information available about the safety of larger amounts used during pregnancy and...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Arrowroot is a starchy powder taken from the roots (rhizomes) of certain tropical plants, most commonly Maranta arundinacea. This plant is native to South America and the Caribbean and is also grown in other warm parts of the world.
To make arrowroot, the roots are washed, pulped, and the starch is separated out and dried into a fine, white powder. It is best known as a thickening agent in cooking, used in sauces, puddings, and gluten-free baking. It also shows up in some baby foods, snacks, and cosmetic products like powders and lotions.
Because it is light and easy to digest, arrowroot has a long history in traditional and home remedies, especially for soothing the stomach and helping with diarrhea.
How it works
Arrowroot is mostly starch, which is a type of carbohydrate. As a thickener, it absorbs water and forms a smooth gel, which is why it is used in cooking and may give a soothing, coating feel in the gut.
Some of its starch is harder to break down quickly and may act somewhat like a fiber, possibly affecting how the gut works and feeding helpful gut bacteria. It also contains small amounts of nutrients such as B vitamins, potassium, and other minerals.
It is important to know that these proposed effects are mostly based on its general properties as a starch and on laboratory or traditional observations, not on robust human studies showing it treats specific diseases.
Does Arrowroot work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Arrowroot, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Irritable bowel syndrome (IBS)
Preliminary clinical research shows that taking powdered arrowroot 10 mL three times daily with meals for one month modestly improves abdominal pain and reduces diarrhea when compared to baseline in patients with diarrhea-predominant IBS. The validity of this finding is limited by the lack of a comparator group. More evidence is needed to rate arrowroot for this use.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, arrowroot starch is generally considered safe and is well tolerated by most people, including in baby foods. It is naturally gluten-free, which makes it a popular choice for people with celiac disease or gluten sensitivity.
Because it is mostly carbohydrate, people with diabetes should count it as a starch and watch their blood sugar. Anyone with a known allergy to arrowroot or related plants should avoid it.
For pregnancy and breastfeeding, arrowroot eaten as a normal food is likely fine, but there is not enough reliable information about using concentrated supplements or medicinal amounts. To be safe, pregnant and breastfeeding women should use caution and check with their doctor or pharmacist before using arrowroot as a remedy.
Side effects
Arrowroot is usually well tolerated. When side effects happen, they are mild and digestive in nature, such as gas, bloating, or stomach discomfort, especially if eaten in large amounts.
Allergic reactions are rare but possible. Stop using it and seek medical help if you notice signs such as rash, itching, swelling, or trouble breathing.
Arrowroot: Reported Adverse Effects
Documented safety reports on Arrowroot from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, arrowroot starch from the root or rhizome is well tolerated when used in the amounts found in foods. There is a limited amount of information available about the adverse effects of arrowroot when used in medicinal amounts. In one clinical trial, it was reported to cause dyspepsia, constipation, and dark stools.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24.
Constipation Gastrointestinal
Orally, arrowroot has been reported to cause dyspepsia, constipation, and dark stools in one clinical trial.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official or standardized medicinal dose for arrowroot. In cooking, it is used in small amounts as a thickener, and there is no established "therapeutic" dose proven to treat any condition.
If you are using a packaged arrowroot product or supplement, follow the directions on the label. When in doubt about how much to use or whether it is right for your situation, check with your pharmacist or doctor.
Arrowroot & Pregnancy
Arrowroot & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Arrowroot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Cooke, C., Carr, I., Abrams, K., and Mayberry, J. Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study. Arq Gastroenterol. 2000;37(1):20-24. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Arrowroot
12 brands in our database make a supplement containing Arrowroot.
Supplement products with Arrowroot
50 products in our database contain Arrowroot. Open any to see its full ingredient list and every drug interaction we check.
Arrowroot: Common Questions
What is Arrowroot used for, and does it work?
Does Arrowroot interact with prescription medications?
How are Arrowroot interactions rated?
Is it safe to take Arrowroot with my medications?
Where does this Arrowroot interaction information come from?
What is Arrowroot used for?
Is Arrowroot safe to eat?
Is Arrowroot gluten-free?
Can I use Arrowroot while pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Arrowroot
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