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Dietary supplement

Daily Prostate Defense Ingredients & Drug Interactions

by Irwin Naturals

Daily Prostate Defense label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Daily Prostate Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Daily Prostate Defense is a dietary supplement by Irwin Naturals with 4 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, urinary problems, hair loss.Based on those ingredients, 1,017 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ginger powder, organic Saw Palmetto powder, organic Papaya juice powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Daily Prostate Defense by Irwin Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Daily Prostate Defense by Irwin Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Daily Prostate Defense by Irwin Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Digestive Proprietary Blend” is a proprietary blend — the label gives one combined amount (6 mg) without saying how much of each component you get.

Daily Prostate Defense contains four active ingredients. The product includes organic ginger powder and organic saw palmetto powder, both traditionally used for prostate and urinary health, along with organic tomato powder and organic papaya juice powder.

There is also a Digestive Proprietary Blend (whose component ingredients are listed separately on the label). The inactive ingredients—rice dextrin, potato starch, gum arabic, arrowroot, and silicon dioxide—are fillers and binders that give the tablet its form.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: optimal support of prostate function.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Non-neurogenic lower urinary tract symptoms (LUTS), Prostate cancer, Prostatitis, urinary flow — and 1 related terms.
  • The closest evidence on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Tomato is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Prostate cancer.
  • Also on file: Saw Palmetto is rated "Insufficient Reliable Evidence To Rate" for Prostate cancer, Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Prostatitis, Non-neurogenic lower urinary tract symptoms (LUTS).

The evidence for this product's ingredients is mixed. Ginger is possibly effective for pregnancy-induced nausea and vomiting, dysmenorrhea (menstrual pain), and osteoarthritis, but it's possibly ineffective for muscle soreness from exercise.

Saw palmetto shows possibly ineffective evidence for benign prostatic hyperplasia (enlarged prostate), and insufficient evidence exists for other uses. Tomato powder and papaya juice powder have insufficient or possibly ineffective evidence for their listed purposes in our data, including prostate health.

We don't hold effectiveness ratings for the Digestive Proprietary Blend.

The evidence, ingredient by ingredient Saw Palmetto Tomato Ginger Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ginger is generally well tolerated in typical food and supplement amounts for most healthy adults. At doses above 5 grams per day, side effects increase—expect abdominal discomfort, burping, diarrhea, heartburn, and a pepper-like irritation in the mouth and throat.

Saw palmetto is usually well tolerated with mild, infrequent side effects like abdominal pain, constipation, diarrhea, dizziness, fatigue, headache, nausea, or vomiting. Tomato powder is well tolerated in typical food amounts.

Papaya juice powder is generally well tolerated as ripe fruit, though concentrated supplements are less well studied. Unripe papaya, papaya latex, and seeds should be avoided.

For pregnancy, ginger is likely or possibly safe, tomato is likely safe, and papaya fruit is likely safe—but saw palmetto should be avoided in pregnancy and while breastfeeding due to possible effects on hormones and insufficient safety data.

Side effects, ingredient by ingredient Saw Palmetto Tomato Ginger Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Papaya, Ginger, Saw Palmetto.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,018 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you take any of these: blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin), diabetes medications, birth control or estrogen therapy, heart medications (especially nifedipine or losartan), thyroid medication (levothyroxine), cancer drugs processed by the liver, or amiodarone. Ginger, saw palmetto, and papaya each carry Moderate-severity interactions with multiple drug classes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Daily Prostate Defense is intended for those seeking prostate and urinary support, but the evidence for its ingredients is limited. If you take blood thinners, diabetes medications, birth control, thyroid medication, or heart drugs, talk with your doctor or pharmacist before starting this product—the interactions are well documented and could affect how your medications work.

Pregnant or breastfeeding individuals should avoid saw palmetto and discuss the ginger content with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Daily Prostate Defense, straight from the product label.

Brand Irwin Naturals
Barcode (UPC) 710363574475
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 45701
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Daily Prostate Defense by Irwin Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
710363574475
IngredientAmount% DV
organic Ginger powder0 NP--
organic Saw Palmetto powder640 mg--
organic Tomato powder360 mg--
Digestive Proprietary Blend6 mg--
organic Papaya juice powder0 NP--

Other ingredients: Rice Dextrin, Potato Starch, Gum Arabic, Arrowroot, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

~Organic Saw Palmetto: One of the best known botanicals for optimal support of prostate function, Saw Palmetto has long been used in Native American traditions.* Derived from Saw Palmetto berries, it delivers targeted nutritional support for the prostate and urinary tract system.* ~ Organic Tomato:The nutrients that give tomatoes their deep red color offer powerful antioxidant potential.* Studies suggest that regular consumption of tomato products may support a healthy prostate.* ~Soothing Organic Papaya and Ginger blend: Every Irwin Organics(R) formula integrates a proprietary blend of organically sourced Papaya and Ginger concentrates, traditionally used as natural digestive aids.*

Saw Palmetto & Tomato for Prostate Health Organic Ginger & Papaya Concentrates Promote Digestive Health

Brand IP Statement(s)

~Irwin Organics(R) Commitment: All of our Irwin Organics(R) products are USDA certified assuring you that 95% or more of our ingredients have been organically produced according to the most stringent standards.

IRWIN Organic(R)

Daily Prostate Defense(TM) A healthy prostate is a key component of a man’s sexual and urinary health.* The natural and organic concentrates in Daily Prostate Defense(TM) have been specially formulated to support your prostate through a unique blend of ingredients.*

General Statements

That means they’re good for your health, and the health of the environment.

~Natural

~Certified

QUESTIONS: Call Consumer Affairs 1-800-297-3273 Weekdays 8:00 am to 5:00 pm (PST)

FDA Disclaimer Statement

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

USAGE WARNING: Do not use if safety seal is broken.

Check with your doctor before using this product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool, dry place.

General

4500-LAB-04/14 IO037447 Ver. 05

Formulation

~Vegan

Certified Organic by: QAI.

Seals/Symbols

USDA ORGANIC

QUALITY ASSURANCE INTERNATIONAL CERTIFIED ORGANIC

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: (Adult) Take two (2) tablets daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Daily Prostate Defense by Irwin Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Daily Prostate Defense label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Daily Prostate Defense by Irwin Naturals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Saw Palmetto powder

Interacts with
174 drugs
640 mg per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Organic Saw Palmetto powder monograph & interactions

Organic Tomato powder

No known
interactions
360 mg per serving

Tomato is a common food rich in vitamins, potassium, and the antioxidant lycopene, and eating it as part of a balanced diet is healthy for most people...

Organic Tomato powder monograph & interactions

Digestive Proprietary Blend

6 mg per serving

Other (inactive) ingredients: Rice Dextrin, Potato Starch, Gum Arabic, Arrowroot, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Daily Prostate Defense by Irwin Naturals Drug Interactions

Want to check YOUR meds against Daily Prostate Defense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,017Drugs
884 Moderate 133 Minor

Ingredients driving the most interactions

organic Ginger powder 1,007
organic Saw Palmetto powder 174
organic Papaya juice powder 92

Individual Drug Interactions

The ingredients in Daily Prostate Defense interact with 1,017 drugs. Click any drug to see the details.

3 of the 4 ingredients in Daily Prostate Defense interact with drugs. Each result below shows which ingredient is responsible. organic Ginger powder organic Saw Palmetto powder organic Papaya juice powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Daily Prostate Defense with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Ginger powder14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
organic Ginger powder full monograph & interactions

organic Saw Palmetto powder3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
organic Saw Palmetto powder full monograph & interactions

organic Papaya juice powder4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
organic Papaya juice powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Daily Prostate Defense, from the product label.

Irwin Naturals

See all Irwin Naturals products
Name
Irwin Naturals(R)
Street Address
5310 Beethoven Street
City
Los Angeles
State
CA
ZipCode
90066
Web Address
www.IrwinNaturals.com
Pharmacist Counseling Corner

Daily Prostate Defense by Irwin Naturals: Common Questions

Does Daily Prostate Defense by Irwin Naturals interact with any medications?
Yes. Based on its ingredients, Daily Prostate Defense has a known interaction with 1,017 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Daily Prostate Defense contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain ingredients that thin the blood?
Ginger and saw palmetto both have antiplatelet effects and may increase bleeding risk when combined with blood thinners or antiplatelet drugs like warfarin or aspirin. Papaya also carries a theoretical bleeding risk with warfarin. If you take any blood thinner, talk with your doctor or pharmacist before starting this product.
Can I take this if I'm on birth control?
Saw palmetto may have antiestrogenic effects and theoretically could reduce the effectiveness of birth control and estrogen therapy. Talk with your doctor or pharmacist before combining this product with your contraceptive.
What are the most common side effects of ginger in this product?
At typical supplement doses, ginger commonly causes abdominal discomfort, burping, diarrhea, heartburn, and a pepper-like irritation in the mouth and throat. These mild symptoms may be reduced by taking encapsulated ginger instead of powdered form. Side effects increase significantly at doses above 5 grams per day.
Is this product safe to use during pregnancy?
Ginger and tomato are likely or possibly safe in pregnancy, and papaya fruit is likely safe. However, saw palmetto should be avoided during pregnancy due to possible hormonal effects and insufficient safety data. Talk with your doctor or pharmacist before taking any supplement while pregnant.
Can I take this if I'm on diabetes medication?
Both ginger and papaya may lower blood sugar or add to the effects of diabetes drugs, potentially increasing your risk of low blood sugar (hypoglycemia). Check with your doctor or pharmacist before using this product if you take antidiabetes medication.
What does saw palmetto do in this product?
Saw palmetto is traditionally used for prostate and urinary health, though the evidence for benign prostatic hyperplasia is possibly ineffective in our data. It is generally well tolerated but may cause mild side effects like diarrhea, dizziness, headache, or nausea.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Daily Prostate Defense label
Go deeper

The Full Monographs Behind Daily Prostate Defense’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Tomato

Tomato is a common food rich in vitamins, potassium, and the antioxidant lycopene, and eating it as part of a balanced diet is healthy for most people. Concentrated tomato or lycopene supple...

Read the full Tomato monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Daily Prostate Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 103 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
  5. Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
  6. Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
  7. Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
  8. Portnoi G, Chng LA, Karimi-Tabesh L, et al. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol 2003;189:1374-7.. PubMed
  9. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9. PubMed
  10. Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 2005;45:74-80. PubMed
  11. Thomson M, Al-Qattan KK, Al-Sawan SM, et al. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002;67:475-8. PubMed
  12. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  13. Akhani SP, Vishwakarma SL, Goyal RK. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 2004;56:101-5.
  14. Kruth P, Brosi E, Fux R, et al. Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother 2004;38:257-60. PubMed
  15. Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2005;59:425-32. PubMed
  16. Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 2005;105:849-56. PubMed
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Papaya 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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