Black Raspberry Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Black Raspberry interacts with medications. The heart of this page is the interaction list — every drug Black Raspberry is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Black Raspberry is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Black Raspberry against your medication
Add one medicationDrugs that interact with Black Raspberry
0 medications have a known interaction with Black Raspberry, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Black Raspberry. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Black Raspberry combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Black Raspberry: Uses, Safety & Side Effects
Black raspberry is a nutrient-rich fruit packed with antioxidants like anthocyanins and ellagic acid, and as a food it is generally safe and healthy. Some early research explores it for cancer prevention, oral health, and heart health, but the evidence is preliminary and far from proven. Enjoy it as part of a balanced diet, and talk to your pharmacist or doctor before using concentrated supplements.

- Scientific name
- Rubus occidentalis
- Family
- Rosaceae
- Part used
- Fruit (berries); sometimes leaves and seeds
- Common forms
- Fresh or frozen berries, juice, powder, capsules, extracts, lozenges, gels
- Antioxidant support
- Heart health
- Oral and gum health
- Cancer prevention (under study)
- Inflammation
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe when eaten as a food; concentrated supplements are less well studied.
When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medic...
Read the full pregnancy detailWhen used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of black raspberry in medic...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Black raspberry (Rubus occidentalis) is a dark purple-black berry that grows on a thorny shrub in the rose family. It is native to eastern North America and is grown in places like the Pacific Northwest of the United States. It is different from the common red raspberry and from the blackberry, though all three are related.
People enjoy black raspberries as a food in jams, juices, and desserts. The fruit is also sold as a juice, powder, or capsule supplement because it is rich in antioxidant compounds. Researchers have shown interest in concentrated forms for possible health uses, but most of this work is still early.
How it works
Black raspberries are rich in plant compounds called anthocyanins (which give the dark color), ellagic acid, ellagitannins, and other polyphenols. These act as antioxidants, meaning they may help neutralize unstable molecules called free radicals that can damage cells.
In laboratory and animal research, these compounds appear to reduce inflammation and may influence how certain cells grow and divide. Some studies suggest they could affect genes and pathways involved in tumor development. However, most of this evidence comes from cells in a dish or from animals, not from large human trials, so we cannot assume the same effects happen in people.
Does Black Raspberry work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Black Raspberry, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Hypertension
Preliminary clinical research shows that taking black raspberry extract 1500 mg or 2500 mg orally daily for 8 weeks reduces 24-hour systolic blood pressure by 1-7 mmHg and nighttime systolic blood pressure by 2-5 mmHg compared to baseline in patients with prehypertension. Compared to the placebo group, these changes were significant. However, taking black raspberry extract does not significantly improve 24-hour diastolic blood pressure, daytime systolic or diastolic blood pressure, nighttime diastolic blood pressure, arterial stiffness, or abdominal visceral fat. The effects of black raspberry on blood pressure in patients with established hypertension has not been studied.
Insufficient Reliable Evidence To Rate Impaired glucose tolerance (prediabetes)
Preliminary clinical research in patients with prediabetes shows that taking black raspberry extract 900 mg or 1800 mg orally daily for 12 weeks decreases glucose area under the curve (AUC) after a 75-gram oral glucose tolerance test compared to placebo. However, taking black raspberry extract does not significantly improve hemoglobin A1c (HbA1c), fasting plasma glucose, insulin AUC, insulin resistance, or the proportion of patients converting to euglycemia.
Insufficient Reliable Evidence To Rate Metabolic syndrome
Preliminary clinical research shows that, in addition to following the dietary approaches to stop hypertension (DASH) diet, taking black raspberry extract 750 mg orally daily for 12 weeks does not affect blood pressure, but does decrease the radial artery augmentation index, a measure of arterial stiffness, compared to placebo in individuals with metabolic syndrome.
Insufficient Reliable Evidence To Rate Oral cancer
Preliminary clinical research shows that applying a 10% black raspberry bioadhesive gel 0.5 grams four times daily for 3 months decreases oral intraepithelial neoplasia (OIN) size by approximately 26%, decreases histopathologic grade, and reduces loss of heterozygosity events, compared to placebo in patients with premalignant oral epithelial lesions. However, 70% of patients enrolled in the trial had a history of lesion recurrence, and 3 months posttreatment, 6 out of 22 patients in the treatment group and 7 out of 17 in the placebo group had recurrence of the lesion at the former treatment site.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, black raspberry is generally considered safe and is part of a healthy diet for most people. Concentrated supplements, extracts, and high-dose powders have not been studied as thoroughly, so their long-term safety is less certain.
People with a known allergy to berries should avoid it. If you have a medical condition or take prescription medicines, check with your pharmacist or doctor before using concentrated products.
For pregnancy and breastfeeding, eating black raspberries as a normal food is generally considered fine. However, there is not enough safety information on concentrated supplement doses, so it is best to use caution and avoid high-dose products unless your healthcare provider approves.
Side effects
Eating black raspberries rarely causes problems. When side effects occur, they are usually mild and may include an upset stomach, loose stools, or gas, especially with large amounts. The seeds can be hard to digest for some people.
Allergic reactions are possible but uncommon. Stop use and seek medical care if you notice rash, itching, swelling, or trouble breathing. Concentrated extracts may carry a higher chance of digestive upset than the whole fruit.
Dosing
There is no official or standardized dose of black raspberry for any health condition. As a food, you can simply enjoy the fresh or frozen berries.
For supplements, juices, and powders, the amount varies widely between products. The best approach is to follow the directions on the product label and not exceed the recommended amount. Because product strength and quality differ, talk with your pharmacist or doctor before starting a concentrated supplement, especially if you have health conditions or take other medicines.
Black Raspberry & Pregnancy
Black Raspberry & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Black Raspberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- An JH, Kim DL, Lee TB, et al. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016;30(10):1634-40.
- Jeong HS, Hong SJ, Cho JY, et al. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial. Nutrition. 2016;32(4):461-7. PubMed
- Mallery SR, Tong M, Shumway BS, et al. Topical application of a mucoadhesive freeze-dried black raspberry gel induces clinical and histologic regression and reduces loss of heterozygosity events in premalignant oral intraepithelial lesions: results from a
- Jeong HS, Kim S, Hong SJ, et al. Black Raspberry Extract Increased Circulating Endothelial Progenitor Cells and Improved Arterial Stiffness in Patients with Metabolic Syndrome: A Randomized Controlled Trial. J Med Food. 2016;19(4):346-52. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Black Raspberry
56 brands in our database make a supplement containing Black Raspberry.
Supplement products with Black Raspberry
187 products in our database contain Black Raspberry. Open any to see its full ingredient list and every drug interaction we check.
Black Raspberry: Common Questions
What is Black Raspberry used for, and does it work?
Does Black Raspberry interact with prescription medications?
How are Black Raspberry interactions rated?
Is it safe to take Black Raspberry with my medications?
Where does this Black Raspberry interaction information come from?
What is Black Raspberry used for?
Is Black Raspberry the same as blackberry?
Is Black Raspberry safe to eat every day?
Can I take Black Raspberry while pregnant?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Black Raspberry
A rotating sample of real supplements in our database that list Black Raspberry — open any to see its full ingredients and every drug interaction we check.
- Black Raspberry by Eclectic Institute
- Turmeric Curcumin Extra Strength by MegaFood
- Full Spectrum Black Raspberry 425 mg by Swanson
- Hema-Plex Chewables Delicious Mixed Berry Flavor by NaturesPlus
- Power Reds Strawberry Kiwi by NuMedica
- Black Raspberry 300 mg by Vitamin World
- Super-5-Berries by North American Herb & Spice
- Adult-Active by Natures Plus
- Daily Turmeric by MegaFood
- Raw Superfoods Natural Berry Flavor by Spring Valley
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