Buckwheat Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Buckwheat interacts with medications. The heart of this page is the interaction list — every drug Buckwheat is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Buckwheat is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Buckwheat against your medication
Add one medicationDrugs that interact with Buckwheat
0 medications have a known interaction with Buckwheat, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Buckwheat. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Buckwheat combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Buckwheat: Uses, Safety & Side Effects
Buckwheat is a nutritious, naturally gluten-free seed that is high in fiber, protein, and antioxidants like rutin. As a food it can be part of a heart-healthy diet, but evidence that buckwheat supplements treat specific conditions is limited. Talk to your pharmacist or doctor before using concentrated extracts.

- Scientific name
- Fagopyrum esculentum
- Family
- Polygonaceae
- Part used
- Seeds (grain), and sometimes the herb (leaves and flowers)
- Common forms
- Flour, groats, whole seeds, tea, capsules/tablets, and extracts
- Heart and circulation health
- Blood sugar support
- Source of fiber and protein
- Antioxidant support
- Varicose veins or leg swelling (traditional)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Buckwheat is generally safe as a food for most people, though allergic reactions can occur.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Buckwheat is a plant grown for its grain-like seeds. Even though its name includes "wheat," it is not related to wheat at all and contains no gluten. It actually belongs to the same plant family as sorrel and knotweed.
Buckwheat is grown in many parts of the world, including Asia, Europe, and North America. The seeds are ground into flour or cooked as groats and used in foods like noodles, pancakes, and porridge. There are different types, including common buckwheat and Tartary buckwheat.
Beyond food, buckwheat is sometimes taken as a supplement or tea, often for its high content of fiber, protein, and plant antioxidants such as rutin.
How it works
Buckwheat contains several compounds that may explain its possible benefits. It is rich in fiber, which can slow digestion, support healthy bowel movements, and help blunt rises in blood sugar after meals.
It is also a good source of rutin and other flavonoid antioxidants. In laboratory and animal studies, these compounds have been shown to fight oxidative stress and may help support blood vessels. Buckwheat also provides quality plant protein, magnesium, and other minerals.
It is important to know that many of these proposed effects come from lab or animal research, or from studies of buckwheat as part of the diet. That does not always translate into proven benefits from taking a supplement.
Does Buckwheat work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Buckwheat, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
A meta-analysis of clinical research shows that taking buckwheat seems to improve some, but not all, markers of CVD risk. Buckwheat was found to decrease total cholesterol by 19 mg/dL, triglycerides by 22 mg/dL, and blood glucose by 15 mg/dL, but had no effect on blood pressure, body weight, insulin, or low-density lipoprotein (LDL) cholesterol when compared with a control group. The patient populations included in this analysis ranged from healthy adults to those with diabetes or hyperlipidemia; it's unclear whether the results are consistent across patient groups or if the benefits are more pronounced in certain types of patients. The effects of buckwheat on cardiovascular events, such as myocardial infarction, stroke, or cardiovascular death, in patients with CVD, are unknown.
Insufficient Reliable Evidence To Rate Chronic venous insufficiency (CVI)
Preliminary clinical research shows that drinking common buckwheat tea for 3 months attenuates leg swelling compared with placebo in patients with chronic venous insufficiency.
Insufficient Reliable Evidence To Rate Diabetes
Preliminary clinical research shows that patients with type 2 diabetes who replace a portion of white rice or white flour with tartary buckwheat 50 grams three times daily for 4 weeks show a 3% reduction in fasting insulin and a 7% reduction in low-density lipoprotein (LDL) cholesterol compared to baseline. Patients who consume the standardized recipe containing white rice and/or white flour three times daily for 4 weeks show no significant changes in these measurements. Neither groups show improvement in fasting blood glucose or hemoglobin A1c levels.
Insufficient Reliable Evidence To Rate Diabetic retinopathy
Preliminary clinical research shows that taking common buckwheat 1 gram three times daily for 3 months does not significantly improve visual acuity compared with baseline in patients with diabetic retinopathy.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, buckwheat is generally safe and is a useful gluten-free option for people who cannot eat wheat. The main concern is allergy. Buckwheat allergy is well documented and can sometimes be serious, including anaphylaxis. People with known buckwheat allergy should avoid it completely.
If you have asthma or other food allergies, be cautious, since allergic reactions to buckwheat appear more common in these groups.
Pregnancy: Eating buckwheat as a normal food is generally considered fine, but concentrated supplements or extracts have not been well studied in pregnancy, so it is safest to avoid them unless your doctor approves.
Breastfeeding: Buckwheat foods are likely fine in normal amounts, but the safety of supplement doses while breastfeeding is unknown. Use caution and check with your pharmacist or doctor.
Side effects
For most people, buckwheat eaten as food causes few problems. Because it is high in fiber, eating large amounts may cause gas, bloating, or stomach upset, especially if you are not used to it.
The most important risk is an allergic reaction. Signs can include hives, itching, swelling, trouble breathing, or, rarely, a severe whole-body reaction (anaphylaxis). If you have any of these symptoms after eating buckwheat, get medical help right away.
Some buckwheat products, like buckwheat hull pillows, can also trigger allergy symptoms in sensitive people.
Buckwheat: Reported Adverse Effects
Documented safety reports on Buckwheat from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionAllergic rhinitis (hay fever) Immunologic
Orally, buckwheat seems to be well tolerated. However, allergic reactions to buckwheat can occur in some adults and children. Symptoms can include skin sensitization, allergic rhinitis, asthma, conjunctivitis, nausea, vomiting, and anaphylaxis.
Occupational exposure to buckwheat, or household exposure through sleeping on a buckwheat husk stuffed-pillow can cause sensitization, of which symptoms include allergic rhinitis and asthma.
- Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6.
- Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
- Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1.
- Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6.
- Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
- Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2.
- De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9.
- Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official standardized supplement dose of buckwheat. As a food, it can simply be eaten as part of a balanced diet, similar to other whole grains and seeds.
For buckwheat capsules, teas, or extracts, the right amount depends on the specific product. Because doses are not well established, the best approach is to follow the directions on the product label and not exceed the recommended amount.
Always check with your pharmacist or doctor before starting a buckwheat supplement, especially if you are pregnant, breastfeeding, have a medical condition, or take other medicines.
Buckwheat & Pregnancy
Buckwheat & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 12 references that drive our Buckwheat monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1. PubMed
- Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6. PubMed
- Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
- Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6. PubMed
- Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
- Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8. PubMed
- Ihme, N., Kiesewetter, H., Jung, F., Hoffmann, K. H., Birk, A., Muller, A., and Grutzner, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled c
- Archimowicz-Cyrylowska B and et al. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytother Res 1996;10(659):62. DOI
- Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2. PubMed
- De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9. PubMed
- Qiu J, Liu Y, Yue Y, Qin Y, Li Z. Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. Nutr Res. 2016 Dec;36(12):1392-1401. PubMed
- Li L, Lietz G, Seal C. Buckwheat and CVD risk markers: a systematic review and meta-analysis. Nutrients. 2018;10(5). pii: E619. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Buckwheat
74 brands in our database make a supplement containing Buckwheat.
Supplement products with Buckwheat
406 products in our database contain Buckwheat. Open any to see its full ingredient list and every drug interaction we check.
Buckwheat: Common Questions
What is Buckwheat used for, and does it work?
Does Buckwheat interact with prescription medications?
How are Buckwheat interactions rated?
Is it safe to take Buckwheat with my medications?
Where does this Buckwheat interaction information come from?
Is Buckwheat gluten-free?
Can Buckwheat help lower blood sugar?
Can I be allergic to Buckwheat?
Is Buckwheat safe to eat during pregnancy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Buckwheat
A rotating sample of real supplements in our database that list Buckwheat — open any to see its full ingredients and every drug interaction we check.
- pH Alkalizer PM Capsules by Greens First Pro
- Perfect Food Super Green Formula by Garden of Life
- Drenamin by SP Standard Process
- Congaplex by SP Standard Process
- Raw Organic Perfect Food Green Superfood Juiced Greens Powder Original by Garden of Life
- Mass Gainer Vanilla Ice Cream by Bodybuilding.com Signature
- Raw Organic Fit Chocolate by Garden of Life
- Organic Sprouted Radiance Blend Chocolate by Health Ranger Select
- Ligaplex I by SP Standard Process
- Raw Organic Perfect Food Chocolate by Garden of Life
Have a question about Buckwheat?
Our pharmacists answer your medication & supplement questions — free.