Costus Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Costus interacts with medications. The heart of this page is the interaction list — every drug Costus is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Costus is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Costus against your medication
Add one medicationDrugs that interact with Costus
0 medications have a known interaction with Costus, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Costus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Costus combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Costus: Uses, Safety & Side Effects
Costus (Saussurea costus) is a root used in Ayurvedic, Unani, and traditional Chinese medicine, mostly for digestive and respiratory complaints. High-quality human evidence is very limited, so its benefits are not well proven. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
- Scientific name
- Saussurea costus
- Family
- Asteraceae
- Part used
- Dried roots and root essential oil
- Common forms
- Dried root powder, capsules, decoctions (teas), essential oil, and topical pastes
- Digestive upset and gas
- Cough and breathing complaints
- Skin conditions (topical)
- Worm and parasite remedies (traditional)
- General tonic in traditional medicine
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Human safety data are limited, and quality and purity of products vary widely.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Costus usually refers to the root of Saussurea costus, a tall flowering plant in the daisy family. It grows mainly in the high mountains of the Himalayas, including parts of India, Pakistan, and China. The dried root and the oil pressed from it have a strong, distinctive smell.
The root has a long history in Ayurvedic, Unani, and traditional Chinese medicine. People have used it for digestion, coughs, skin problems, and as a general tonic. It is also used in perfumes and incense. Today it is sold as a powder, in capsules, as a tea, and as an essential oil.
Because Saussurea costus is considered an endangered and protected species in some regions, harvesting and trade may be restricted in certain places.
How it works
Costus root contains compounds called sesquiterpene lactones, including ones often named costunolide and dehydrocostus lactone, along with essential oils. In laboratory and animal studies, these compounds have shown anti-inflammatory, antimicrobial, and antioxidant activity.
Researchers think these actions might explain some of the traditional uses, such as calming the gut or fighting germs. However, what happens in a test tube or in animals does not always carry over to people. The way costus works in the human body, and at what dose, is not well understood.
Does Costus work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Costus, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Intestinal parasite infection
It is unclear if oral costus root is beneficial in children with intestinal parasite infections.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
There is limited human safety information for costus. Product quality and strength can vary a lot, and some plant products may be contaminated or mislabeled. The essential oil is concentrated and should not be swallowed unless a qualified professional directs it.
Some people are allergic to plants in the daisy (Asteraceae) family, such as ragweed, marigold, and chamomile. If that includes you, you may be more likely to react to costus. Pregnant people should avoid costus, since it has traditionally been thought to stimulate the uterus. Breastfeeding people should also avoid it because of a lack of safety data. Children, and people with liver, kidney, or chronic health conditions, should not use it without medical advice.
Always check with a pharmacist or doctor before starting costus, especially if you take prescription medicines or have an ongoing health problem.
Side effects
Because costus has not been well studied in people, its full side-effect profile is not known. Possible effects include stomach upset, nausea, or allergic skin reactions, especially in people sensitive to daisy-family plants.
Applied to the skin, the oil may cause irritation or rash in some people. Rarely, herbal products can cause more serious allergic reactions. Stop using costus and seek medical care if you have swelling, trouble breathing, a spreading rash, or other signs of a serious reaction.
Costus: Reported Adverse Effects
Documented safety reports on Costus from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionDermatitis Immunologic
Orally and topically, costus might cause allergic reactions, including contact dermatitis.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Marzulli, F. N. and Maibach, H. I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976;2(6):325-329.
- Mitchell, J. C. Contact hypersensitivity to some perfume materials. Contact Dermatitis 1975;1(4):196-199.
- Benezra, C. and Epstein, W. L. Molecular recognition patterns of sesquiterpene lactones in costus-sensitive patients. Contact Dermatitis 1986;15(4):223-230.
- Mitchell, J. C. and Epstein, W. L. Contact hypersensitivity to a perfume material, Costus Absolute. The role of sesquiterpene lactones. Arch.Dermatol 1974;110(6):871-873.
- Cheminat, A., Stampf, J. L., Benezra, C., Farrall, M. J., and Frechet, J. M. Allergic contact dermatitis to costus: removal of haptens with polymers. Acta Derm.Venereol. 1981;61(6):525-529.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established or standardized dose of costus for any health condition. Traditional preparations vary widely, and the strength of commercial products is not consistent.
If you choose to use a costus product, follow the directions on the label and do not exceed them. The essential oil is very concentrated and should not be taken by mouth without professional guidance. Talk with a pharmacist or doctor about whether costus is appropriate for you and what amount, if any, might be reasonable.
Costus & Pregnancy
Costus & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 6 references that drive our Costus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Marzulli, F. N. and Maibach, H. I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976;2(6):325-329. PubMed
- Mitchell, J. C. Contact hypersensitivity to some perfume materials. Contact Dermatitis 1975;1(4):196-199. PubMed
- Benezra, C. and Epstein, W. L. Molecular recognition patterns of sesquiterpene lactones in costus-sensitive patients. Contact Dermatitis 1986;15(4):223-230. PubMed
- Mitchell, J. C. and Epstein, W. L. Contact hypersensitivity to a perfume material, Costus Absolute. The role of sesquiterpene lactones. Arch.Dermatol 1974;110(6):871-873. DOI
- Cheminat, A., Stampf, J. L., Benezra, C., Farrall, M. J., and Frechet, J. M. Allergic contact dermatitis to costus: removal of haptens with polymers. Acta Derm.Venereol. 1981;61(6):525-529. DOI
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Costus
18 brands in our database make a supplement containing Costus.
Supplement products with Costus
113 products in our database contain Costus. Open any to see its full ingredient list and every drug interaction we check.
Costus: Common Questions
What is Costus used for, and does it work?
Does Costus interact with prescription medications?
How are Costus interactions rated?
Is it safe to take Costus with my medications?
Where does this Costus interaction information come from?
What is Costus used for?
Is Costus safe to take?
Can I use Costus during pregnancy or breastfeeding?
How is Costus usually taken?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Costus
A rotating sample of real supplements in our database that list Costus — open any to see its full ingredients and every drug interaction we check.
- Codonopsis & Longan Combination by Ron Teeguarden's Dragon Herbs
- Xiang Sha Yang Wei Pian StomachVigor by Guang Ci Tang
- Padma Basic Professional by Clinical Synergy Professional Formulas
- Curing Pills by Plum Flower
- Aucklandia & Coptis Teapills by Plum Flower
- OptDigest by Ron Teeguarden's Dragon Herbs
- Mu Xiang Shun Qi Wan by Min Shan
- Soothe Liver Teapills by Plum Flower
- Shu Gan by Health Concerns
- Costus Alcohol Free by Hawaii Pharm
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