Herb & supplement monograph

Costus Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Costus

0 medications have a known interaction with Costus, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Costus. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Costus combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Costus: Uses, Safety & Side Effects

The bottom line

Costus (Saussurea costus) is a root used in Ayurvedic, Unani, and traditional Chinese medicine, mostly for digestive and respiratory complaints. High-quality human evidence is very limited, so its benefits are not well proven. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Scientific name
Saussurea costus
Family
Asteraceae
Part used
Dried roots and root essential oil
Common forms
Dried root powder, capsules, decoctions (teas), essential oil, and topical pastes
People commonly use it for
  • Digestive upset and gas
  • Cough and breathing complaints
  • Skin conditions (topical)
  • Worm and parasite remedies (traditional)
  • General tonic in traditional medicine

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Human safety data are limited, and quality and purity of products vary widely.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Costus usually refers to the root of Saussurea costus, a tall flowering plant in the daisy family. It grows mainly in the high mountains of the Himalayas, including parts of India, Pakistan, and China. The dried root and the oil pressed from it have a strong, distinctive smell.

The root has a long history in Ayurvedic, Unani, and traditional Chinese medicine. People have used it for digestion, coughs, skin problems, and as a general tonic. It is also used in perfumes and incense. Today it is sold as a powder, in capsules, as a tea, and as an essential oil.

Because Saussurea costus is considered an endangered and protected species in some regions, harvesting and trade may be restricted in certain places.

How it works

Costus root contains compounds called sesquiterpene lactones, including ones often named costunolide and dehydrocostus lactone, along with essential oils. In laboratory and animal studies, these compounds have shown anti-inflammatory, antimicrobial, and antioxidant activity.

Researchers think these actions might explain some of the traditional uses, such as calming the gut or fighting germs. However, what happens in a test tube or in animals does not always carry over to people. The way costus works in the human body, and at what dose, is not well understood.

Effectiveness

Does Costus work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Costus, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Intestinal parasite infection
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral costus root is beneficial in children with intestinal parasite infections.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

There is limited human safety information for costus. Product quality and strength can vary a lot, and some plant products may be contaminated or mislabeled. The essential oil is concentrated and should not be swallowed unless a qualified professional directs it.

Some people are allergic to plants in the daisy (Asteraceae) family, such as ragweed, marigold, and chamomile. If that includes you, you may be more likely to react to costus. Pregnant people should avoid costus, since it has traditionally been thought to stimulate the uterus. Breastfeeding people should also avoid it because of a lack of safety data. Children, and people with liver, kidney, or chronic health conditions, should not use it without medical advice.

Always check with a pharmacist or doctor before starting costus, especially if you take prescription medicines or have an ongoing health problem.

Side effects

Because costus has not been well studied in people, its full side-effect profile is not known. Possible effects include stomach upset, nausea, or allergic skin reactions, especially in people sensitive to daisy-family plants.

Applied to the skin, the oil may cause irritation or rash in some people. Rarely, herbal products can cause more serious allergic reactions. Stop using costus and seek medical care if you have swelling, trouble breathing, a spreading rash, or other signs of a serious reaction.

Costus: Reported Adverse Effects

Documented safety reports on Costus from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established or standardized dose of costus for any health condition. Traditional preparations vary widely, and the strength of commercial products is not consistent.

If you choose to use a costus product, follow the directions on the label and do not exceed them. The essential oil is very concentrated and should not be taken by mouth without professional guidance. Talk with a pharmacist or doctor about whether costus is appropriate for you and what amount, if any, might be reasonable.

Pregnancy & Breastfeeding

Costus & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Costus & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 6 references that drive our Costus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Marzulli, F. N. and Maibach, H. I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Contact Dermatitis 1976;2(6):325-329. PubMed
  3. Mitchell, J. C. Contact hypersensitivity to some perfume materials. Contact Dermatitis 1975;1(4):196-199. PubMed
  4. Benezra, C. and Epstein, W. L. Molecular recognition patterns of sesquiterpene lactones in costus-sensitive patients. Contact Dermatitis 1986;15(4):223-230. PubMed
  5. Mitchell, J. C. and Epstein, W. L. Contact hypersensitivity to a perfume material, Costus Absolute. The role of sesquiterpene lactones. Arch.Dermatol 1974;110(6):871-873. DOI
  6. Cheminat, A., Stampf, J. L., Benezra, C., Farrall, M. J., and Frechet, J. M. Allergic contact dermatitis to costus: removal of haptens with polymers. Acta Derm.Venereol. 1981;61(6):525-529. DOI
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Costus

113 products in our database contain Costus. Open any to see its full ingredient list and every drug interaction we check.

Soothe Liver Teapills by Plum Flower Tablet Or Pill 1.2 Ounce(s) · 34 Gram(s) · 200 Pill(s) View ingredients & interactions Soothe Liver Teapills by Plum Flower Tablet Or Pill 1.2 Ounce(s) · 34 Gram(s) · 200 Pill(s) View ingredients & interactions Ultra R by New Sun Capsule 100 Capsule(s) View ingredients & interactions Xiang Sha Liu Jun Zi Pian Stomakinder 200 mg by Guang Ci Tang Tablet Or Pill 200 Tablet(s) View ingredients & interactions Xiang Sha Yang Wei Pian StomachVigor by Guang Ci Tang Tablet Or Pill 200 Tablet(s) · 40 Gram(s) View ingredients & interactions Xiang Sha Yang Wei Wan by Min Shan Tablet Or Pill 1.2 Ounce(s) · 33 Gram(s) · 200 Pill(s) View ingredients & interactions Xiang Sha Yang Wei Wan by Min Shan Tablet Or Pill 1.2 Ounce(s) · 200 Pill(s) · 34 Gram(s) View ingredients & interactions Zizzz by Princess Lifestyle Capsule 60 Capsule(s) View ingredients & interactions Aplotaxis Amomum Pills Xiang Sha Liu Jun Wan by Min Shan Tablet Or Pill 200 Pill(s) · 1.2 oz. · 34 Gram(s) Off market View ingredients & interactions Aucklandia & Coptis Teapills Xiang Lian Wan by Plum Flower Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Aucklandia & Coptis Teapills Xiang Lian Wan by Plum Flower Tablet Or Pill 1.2 oz. · 33 Gram(s) · 200 Pill(s) Off market View ingredients & interactions Clear Channels Teapills Juan Bi Wan by Plum Flower Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Clear Channels Teapills Juan Bi Wan by Plum Flower Brand Tablet Or Pill 1.2 oz. · 33 Gram(s) · 200 Pill(s) Off market View ingredients & interactions Costus Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL Off market View ingredients & interactions Curing Pills by Plum Flower Capsule 30 Capsule(s) · 0.53 Oz(s) · 15 Gram(s) Off market View ingredients & interactions Curing Pills by Plum Flower Capsule 30 Capsule(s) · 0.48 Oz(s) · 13.6 Gram(s) Off market View ingredients & interactions Ease Plus by Health Concerns Capsule 90 Capsule(s) Off market View ingredients & interactions Essential Detox by AN American Nutriceuticals Tablet Or Pill 60 Tablet(s) Off market View ingredients & interactions Fortify Stomach Teapills by Plum Flower Brand Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Gui Pi Teapills by Plum Flower Tablet Or Pill 200 Pill(s) · 1.2 Ounce(s) · 33 Gram(s) Off market View ingredients & interactions Gui Pi Teapills Gui Pi Wan by Plum Flower Tablet Or Pill 5.8 oz. · 165 g · 1000 Pill(s) Off market View ingredients & interactions Gui Pi Teapills Gui Pi Wan by Plum Flower Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Gui Pi Teapills Gui Pi Wan by Plum Flower Tablet Or Pill 6 oz. · 170 Gram(s) · 1000 Pill(s) Off market View ingredients & interactions Gui Pi Teapills Gui Pi Wan by Plum Flower Tablet Or Pill 1.2 oz. · 34 Gram(s) · 200 Pill(s) Off market View ingredients & interactions
Pharmacist Counseling Corner

Costus: Common Questions

What is Costus used for, and does it work?
People use Costus for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Costus interact with prescription medications?
We do not currently list any known drug interactions for Costus. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Costus interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Costus with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Costus interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Costus used for?
It is most often used in traditional medicine for digestive problems like gas and bloating, and for coughs and breathing complaints. These uses are based largely on tradition rather than strong human studies.
Is Costus safe to take?
There is limited human safety data, so it is best used with caution and under the guidance of a pharmacist or doctor. People allergic to daisy-family plants may be more likely to react to it.
Can I use Costus during pregnancy or breastfeeding?
No. Costus has traditionally been thought to stimulate the uterus, and there is not enough safety information, so it should be avoided during pregnancy and breastfeeding.
How is Costus usually taken?
It is available as a root powder, capsules, teas, and essential oil. Follow the product label and avoid swallowing the essential oil unless a qualified professional directs it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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