Medication interaction hub

What Supplements Interact with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium brand name: Hista-Derfule. Every interaction below applies to the brands too.

332 Interactions 18 Major 267 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hista-Derfule is really four medicines at once: acetaminophen, the antihistamine chlorpheniramine, the decongestant phenylpropanolamine, and opium. That mix is why I read its 332 supplement interactions with genuine care, starting with the 18 rated major. Because the opioid and antihistamine both sedate, alcohol, kava, and similar calming herbs can deepen drowsiness into dangerously slowed breathing. The decongestant pulls the opposite way, so stimulant herbs like ephedra can push blood pressure and heart strain too high.

Acetaminophen brings its own liver concern; 38 of these ingredients can also stress the liver, and 30 more add to the antihistamine's drying, constipating anticholinergic side effects. Most of the 267 moderate and 47 minor entries echo these themes more gently or change how the body clears the drug. Start with the major entries below, and ask a pharmacist before pairing this medicine with any supplement that makes you sleepy or wired.

— , Clinical Pharmacist · July 18, 2026

Major 18 Moderate 267 Minor 47 No known interaction 1,120

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium: Top Interactions at a Glance

The Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 332 interacting ingredients — plus 1,120 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium Combinations Today

The Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Vitamin D + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Cascara Sagrada + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Unlikely Gamma-aminobutyric Acid (gaba) + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Read the full interaction Minor Likelihood Unlikely Pomegranate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opiumi

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically signif...

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium

All 1,452 ingredients in our database, ranked by severity — 332 with a Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction on file and 1,120 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin D with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Beet with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Astaxanthin with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Cascara Sagrada with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.

Full Cascara Sagrada + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Gamma-aminobutyric Acid (gaba) with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Karaya Gum with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Marshmallow with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take N-methyltyramine with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. N-methyltyramine is thought to have stimulant effects.

Full N-methyltyramine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Octopamine with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Octopamine is thought to have stimulant effects.

Full Octopamine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Puravive with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Rhodiola with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.

Full Rhodiola + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Tyramine with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking tyramine with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Tyramine + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Xanthan Gum with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Asian Water Plantain with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Calabar Bean with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Calendula with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Chrysin with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Deanol with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Diindolylmethane with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Full Diindolylmethane + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer

Can you take Humann Superbeets Heart Chews with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium sits in 20 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium through this category.

Related: does Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium deplete any nutrients?

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium has 1 reported nutrient association in the research literature — see the Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium & Supplements: Common Questions

What supplements interact with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?
In our interaction database, 332 supplement and herbal ingredients have an interaction with Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium on file — 18 rated major, 267 moderate, and 47 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium supplement interactions are the most serious?
The 18 major-rated combinations — led by Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?
That depends entirely on which supplement. The honest answer for Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Hista-Derfule have the same supplement interactions as Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium?
Yes — Hista-Derfule all contain Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium deplete any vitamins or nutrients?
It might — Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium and my other medications?
This page covers Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium against supplements and herbal ingredients. Checking Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.