Medication interaction hub

What Supplements Interact with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine brand name: Anatuss. Every interaction below applies to the brands too.

261 Interactions 12 Major 206 Moderate 43 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anatuss combines acetaminophen, dextromethorphan, guaifenesin, and phenylpropanolamine, and its supplement list is not one to skim, since 12 of the 261 ingredients on file carry a major rating. Two hazards top the pile. Anything stimulating, everyday caffeine included, stacks on the phenylpropanolamine and can push blood pressure and heart rate too high, while heavy alcohol use raises the odds of liver injury from the acetaminophen.

Most of the 206 moderate and 43 minor entries shift how the ingredients are broken down, nudging their levels up or down, and activated charcoal can cut how much of the medicine you absorb at all. Dextromethorphan adds its own wrinkle. Around 20 entries have serotonergic activity, and stacked together they can, at worst, tip toward serotonin syndrome, a dangerous buildup of serotonin. That is the interaction I would check for first in any mood or sleep supplement.

— , Clinical Pharmacist · July 18, 2026

Major 12 Moderate 206 Minor 43 No known interaction 1,191

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine: Top Interactions at a Glance

The Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 261 interacting ingredients — plus 1,191 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine Combinations Today

The Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Seed + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vaso...

Read the full interaction Minor Likelihood Possible Honey + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Read the full interaction Minor Likelihood Possible Algin + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Theoretically, algin can alter the absorption of oral drugs.

Read the full interaction Major Likelihood Probable Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction Major Likelihood Likely Grapefruit + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolaminei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 261 with a Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction on file and 1,191 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Honey with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Algin with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Lithium with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Bitter Orange with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Black Cohosh with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.

Full Black Cohosh + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Black Hoof Mushroom with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Full Black Hoof Mushroom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Black Pepper with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.

Full Black Pepper + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Bog Labrador Tea with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Boldo with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Boswellia Serrata with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.

Full Boswellia Serrata + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Breadfruit with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).

Full Breadfruit + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Broccoli with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.

Full Broccoli + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Buchu with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Bulbine Natalensis with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.

Full Bulbine Natalensis + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Butcher's Broom with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Cajeput Oil with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that cajeput leaf extract can inhibit cytochrome P450 2D6 (CYP2D6) by approximately 30%.

Full Cajeput Oil + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Calamus with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP2D6 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Calcium D-glucarate with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.

Full Calcium D-glucarate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer

Can you take Camphor with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine sits in 16 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine through this category.

Related: does Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine deplete any nutrients?

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine has 1 reported nutrient association in the research literature — see the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine.

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Pharmacist Counseling Corner

Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?
Our database currently documents 261 ingredients with a known Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction (12 major, 206 moderate, 43 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 261. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?
Plenty of supplements coexist fine with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Anatuss have the same supplement interactions as Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?
Yes — Anatuss all contain Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine deplete any vitamins or nutrients?
It might — Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine and my other medications?
This page covers Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine against supplements and herbal ingredients. Checking Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.