Sulforaphane + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine brand name: Anatuss.
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine falls into 3 drug categories that Sulforaphane can interact with; the most serious is rated moderate. Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Read the full interaction reportSulforaphane and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Sulforaphane interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine falls into 3 of those categories, so it can interact with Sulforaphane in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
1 of 3Why this applies to Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Sulforaphane interacts with.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This is a combination cold and cough product, and the piece that touches sulforaphane here is the dextromethorphan (the cough suppressant). Sulforaphane is one of many things that may nudge a liver enzyme called CYP1A2, which helps process dextromethorphan. The catch is that the research goes both ways: in lab and animal studies sulforaphane can slow this enzyme, while a related broccoli compound can speed it up. Either could in theory shift how much dextromethorphan is in your system, possibly more drowsiness and dizziness, or possibly less cough relief.
Honestly, this has never been shown in real people, and broccoli on your dinner plate is not a concern. If you take a concentrated sulforaphane capsule, just run it by your pharmacist.
- Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
- Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
- Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination cold-and-cough product (Anatuss) contains four ingredients, and the one that actually leans on the CYP3A4 enzyme is dextromethorphan, the cough suppressant. The thinking here is that sulforaphane might slow that enzyme down a little, which could let dextromethorphan build up. If that happened, you might notice more of its typical effects, like drowsiness, dizziness, or a foggy, lightheaded feeling.
Here's the honest part: this concern comes only from lab and animal studies, not from real people, so it's largely theoretical. Eating broccoli at dinner is very unlikely to cause trouble. A concentrated sulforaphane supplement is the bigger question mark. If you take one regularly, just run it by your pharmacist or doctor before mixing.
- Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
- Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
- Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES
3 of 3Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine also falls under CYTOCHROME P450 2E1 (CYP2E1) SUBSTRATES.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo cold and cough product (Anatuss) contains acetaminophen, dextromethorphan, guaifenesin, and phenylpropanolamine. The piece that matters here is the acetaminophen (Tylenol). Your liver uses an enzyme called CYP2E1 to break down a small portion of acetaminophen into a harmful byproduct. In lab dishes, sulforaphane appears to slow that enzyme down. In plain terms, that would mean less of the harmful byproduct forms, which is not a worrisome direction.
Here is the reassuring part: this has only been seen in test tubes, never reported in real people, and the broccoli you eat at dinner is not a concern. If you take a concentrated sulforaphane capsule alongside acetaminophen, just keep your acetaminophen within the labeled daily limit and check with your pharmacist if you have any liver concerns.
- Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Sulforaphane Also Interacts With Other Medications
Sulforaphane has 723 moderate known drug interactions in our database — the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Sulforaphane
We haven’t checked that one against Sulforaphane yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Sulforaphane. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine
This page covers Sulforaphane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine page lists 261 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).
By severity: 12 major · 206 moderate · 43 minor.
From our pharmacist’s overview on the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine page
“Anatuss combines acetaminophen, dextromethorphan, guaifenesin, and phenylpropanolamine, and its supplement list is not one to skim, since 12 of the 261 ingredients on file carry a major rating. Two hazards top the pile.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction page
Taking Sulforaphane as Part of a Dietary Supplement Product? Check It for Interactions
We hold 167 real supplement products containing Sulforaphane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sulforaphane. Your product may carry other ingredients that interact with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine too, on top of Sulforaphane — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Sulforaphane and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#466 of 1,452 supplements looked up here in the last 7 days
#64 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Sulforaphane
What is Sulforaphane?
- Antioxidant support
- General cellular health
- Detoxification support
- Inflammation
- Skin and aging concerns
Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evidence for most specific health claims is still limited. It is generally well tolerated as part of a vegetable-rich diet, but if you take a concentrated supplement, talk to your pharmacist or doctor first.
Other Drugs & Sulforaphane
Browse every other medication we’ve checked against Sulforaphane — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
723 interactions
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Acetaminophen ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Etoposide ›
- Fluticasone Propionate ›
- Hydroxyzine ›
- Itraconazole ›
- Midazolam ›
- Modafinil ›
Showing 60 of 723 moderate interactions — see all 723 on the Sulforaphane page.
No interaction 2,106 drugs checked — show the list
We also checked Sulforaphane against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Methamphetamine ›
- Metformin ›
- Lisdexamfetamine ›
- Semaglutide ›
- Hydroxyurea ›
- Valacyclovir ›
- Amphetamine ›
- Sumatriptan ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Duloxetine ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetylsalicylic Acid ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Insulin Degludec, Liraglutide ›
- Bisoprolol ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate ›
- Aminophylline, Amobarbital, Ephedrine ›
- Aspirin, Butalbital ›
- Atenolol, Chlorthalidone ›
- Enalapril Maleate ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Ephedrine, Phenobarbital, Theophylline ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Cephalexin ›
- Rosiglitazone Maleate ›
- Sacubitril, Valsartan ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Levetiracetam ›
- Aspirin, Ethoheptazine, Meprobamate ›
- Levodopa ›
- Nebivolol Hydrochloride, Valsartan ›
- Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide ›
- Cyclopentolate ›
Showing the 60 most looked-up of 2,106 medications checked with no known interaction — see the full Sulforaphane list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine as a medicine that can lower these. This is not an interaction with Sulforaphane — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Sulforaphane and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine Together: Common Questions
Can you take Sulforaphane with Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?
Why are there 3 interactions listed for Sulforaphane and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine?
How serious is the Sulforaphane and Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.