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What Supplements Interact with Belladonna, Ergotamine Tartrate, Phenobarbital?

250 Interactions 11 Major 200 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belladonna, Ergotamine Tartrate, Phenobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belladonna, Ergotamine Tartrate, Phenobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

This belladonna, ergotamine, and phenobarbital combination, an older migraine treatment built around a sedating barbiturate, calls for real vigilance where supplements are concerned. The heaviest risk is stacked sedation. Alcohol, kava, GHB and related compounds can deepen phenobarbital's depressant pull on the brain and breathing. Grapefruit adds risk from another angle by raising blood levels of drugs cleared through the CYP3A4 enzyme, while St. John's wort does the opposite, speeding phenobarbital's breakdown enough to blunt its effect.

The belladonna side brings its own problem, since dozens of herbs with atropine-like activity, henbane and scopolia among them, pile onto its drying anticholinergic effects. Activated charcoal works differently, soaking up oral doses before they absorb, so keep it well separated from this medication. Across the 250 ingredients on file, 200 rate moderate and 39 minor, but the 11 majors, most of them sedatives, are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 200 Minor 39 No known interaction 1,202

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Belladonna, Ergotamine Tartrate, Phenobarbital: Top Interactions at a Glance

The most significant Belladonna, Ergotamine Tartrate, Phenobarbital supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 250 interacting ingredients — plus 1,202 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Belladonna, Ergotamine Tartrate, Phenobarbital + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Belladonna, Ergotamine Tartrate, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Belladonna, Ergotamine Tartrate, Phenobarbitali

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely St. John's Wort + Belladonna, Ergotamine Tartrate, Phenobarbitali

St.

Read the full interaction Major Likelihood Likely Wine + Belladonna, Ergotamine Tartrate, Phenobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Belladonna, Ergotamine Tartrate, Phenobarbitali

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Belladonna, Ergotamine Tartrate, Phenobarbitali

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Belladonna, Ergotamine Tartrate, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 250 with a Belladonna, Ergotamine Tartrate, Phenobarbital interaction on file and 1,202 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belladonna, Ergotamine Tartrate, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Eleuthero with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Ginger with Belladonna, Ergotamine Tartrate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Folic Acid with Belladonna, Ergotamine Tartrate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.

Full Folic Acid + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Gymnema with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Humann Superbeets Heart Chews with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Jequirity with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Mommy's Bliss Gripe Water with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Polypodium Leucotomos with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Pomegranate with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Red Clover with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Tangerine with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Theanine with Belladonna, Ergotamine Tartrate, Phenobarbital?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Full Theanine + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Beer with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Grapefruit with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take St. John's Wort with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Wine with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take 1,4-butanediol with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Activated Charcoal with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Gamma-hydroxybutyrate (ghb) with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Belladonna, Ergotamine Tartrate, Phenobarbital answer

Can you take Henbane with Belladonna, Ergotamine Tartrate, Phenobarbital?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Belladonna, Ergotamine Tartrate, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belladonna, Ergotamine Tartrate, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belladonna, Ergotamine Tartrate, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belladonna, Ergotamine Tartrate, Phenobarbital sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Ergot Derivatives 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Belladonna, Ergotamine Tartrate, Phenobarbital through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belladonna, Ergotamine Tartrate, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belladonna, Ergotamine Tartrate, Phenobarbital.

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Pharmacist Counseling Corner

Belladonna, Ergotamine Tartrate, Phenobarbital & Supplements: Common Questions

What supplements interact with Belladonna, Ergotamine Tartrate, Phenobarbital?
In our interaction database, 250 supplement and herbal ingredients have an interaction with Belladonna, Ergotamine Tartrate, Phenobarbital on file — 11 rated major, 200 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, St. John's Wort.
Which Belladonna, Ergotamine Tartrate, Phenobarbital supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, St. John's Wort, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Belladonna, Ergotamine Tartrate, Phenobarbital?
That depends entirely on which supplement. The honest answer for Belladonna, Ergotamine Tartrate, Phenobarbital is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Belladonna, Ergotamine Tartrate, Phenobarbital and my other medications?
This page covers Belladonna, Ergotamine Tartrate, Phenobarbital against supplements and herbal ingredients. Checking Belladonna, Ergotamine Tartrate, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.