Medication interaction hub

What Supplements Interact with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Bismuth Subsalicylate, Metronidazole, Tetracycline brand name: Helidac. Every interaction below applies to the brands too.

148 Interactions 6 Major 128 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bismuth Subsalicylate, Metronidazole, Tetracycline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bismuth Subsalicylate, Metronidazole, Tetracycline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

148 supplements and herbal ingredients have interactions with Bismuth Subsalicylate, Metronidazole, Tetracycline on file in the HelloPharmacist interaction database — 6 rated major, 128 moderate, and 14 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Oleander and Wine.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Bismuth Subsalicylate, Metronidazole, Tetracycline.

Major 6 Moderate 128 Minor 14 No known interaction 1,304

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Bismuth Subsalicylate, Metronidazole, Tetracycline: Top Interactions at a Glance

The most significant Bismuth Subsalicylate, Metronidazole, Tetracycline supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Bismuth Subsalicylate, Metronidazole, Tetracycline + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Oleander + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.

Read the full interaction Major Likelihood Probable Wine + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Possible Asarabacca + Bismuth Subsalicylate, Metronidazole, Tetracyclinei

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Bismuth Subsalicylate, Metronidazole, Tetracycline

All 1,452 ingredients in our database, ranked by severity — 148 with a Bismuth Subsalicylate, Metronidazole, Tetracycline interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bismuth Subsalicylate, Metronidazole, Tetracycline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lactobacillus Delbrueckii with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Delbrueckii + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Star Of Bethlehem with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.

Full Star Of Bethlehem + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Swamp Milkweed with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tetracycline antibiotics might increase the risk of toxicity from cardioactive steroids in swamp milkweed.

Full Swamp Milkweed + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Sweet Annie with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Sweet Clover with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Syrian Rue with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Testolone with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Thuja with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Thunder God Vine with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of thunder god vine constituents.

Full Thunder God Vine + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Tragacanth with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Turmeric with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Uzara with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Full Uzara + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Vitamin A with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Wahoo with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase risk of cardiac glycoside toxicity.

Full Wahoo + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Yohimbe with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.

Full Yohimbe + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Green Tea with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Thyroid Extract with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Agar with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Algin with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Bismuth Subsalicylate, Metronidazole, Tetracycline answer

Can you take Black Psyllium with Bismuth Subsalicylate, Metronidazole, Tetracycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Bismuth Subsalicylate, Metronidazole, Tetracycline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bismuth Subsalicylate, Metronidazole, Tetracycline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bismuth Subsalicylate, Metronidazole, Tetracycline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bismuth Subsalicylate, Metronidazole, Tetracycline sits in 10 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Tetracycline Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

Metronidazole (Flagyl) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Bismuth Subsalicylate, Metronidazole, Tetracycline through this category.

About Bismuth Subsalicylate, Metronidazole, Tetracycline

A three-drug antibiotic and bismuth combination capsule, taken together with omeprazole, used to clear Helicobacter pylori (H. pylori) infection in people with a duodenal ulcer or a recent history of one.

Generic name: Bismuth Subsalicylate, Metronidazole, Tetracycline  ·  Brand name: Helidac.

See the full Bismuth, Metronidazole, and Tetracycline drug information

Related: does Bismuth Subsalicylate, Metronidazole, Tetracycline deplete any nutrients?

Bismuth Subsalicylate, Metronidazole, Tetracycline has 7 reported nutrient associations in the research literature — see the Bismuth Subsalicylate, Metronidazole, Tetracycline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bismuth Subsalicylate, Metronidazole, Tetracycline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bismuth Subsalicylate, Metronidazole, Tetracycline.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Bismuth Subsalicylate, Metronidazole, Tetracycline-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Bismuth Subsalicylate, Metronidazole, Tetracycline.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Bismuth Subsalicylate, Metronidazole, Tetracycline & Supplements: Common Questions

What supplements interact with Bismuth Subsalicylate, Metronidazole, Tetracycline?
More than you might expect — 148 in total, though they are far from equal: 6 are rated major, 128 moderate, and 14 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Bismuth Subsalicylate, Metronidazole, Tetracycline supplement interactions are the most serious?
The 6 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Oleander and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bismuth Subsalicylate, Metronidazole, Tetracycline?
Usually yes — most people on Bismuth Subsalicylate, Metronidazole, Tetracycline can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Helidac have the same supplement interactions as Bismuth Subsalicylate, Metronidazole, Tetracycline?
Yes — Helidac all contain Bismuth Subsalicylate, Metronidazole, Tetracycline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bismuth Subsalicylate, Metronidazole, Tetracycline deplete any vitamins or nutrients?
It might — Bismuth Subsalicylate, Metronidazole, Tetracycline has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bismuth Subsalicylate, Metronidazole, Tetracycline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bismuth Subsalicylate, Metronidazole, Tetracycline and my other medications?
This page covers Bismuth Subsalicylate, Metronidazole, Tetracycline against supplements and herbal ingredients. Checking Bismuth Subsalicylate, Metronidazole, Tetracycline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Bismuth, Metronidazole, and Tetracycline drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.