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What Supplements Interact with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Dolutegravir, Emtricitabine, Tenofovir alafenamide brand name: Dolutegravir, Emtricitabine, Tenofovir Alafenamide. Every interaction below applies to the brands too.

107 Interactions 7 Major 84 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 29, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dolutegravir, Emtricitabine, Tenofovir alafenamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dolutegravir, Emtricitabine, Tenofovir alafenamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A plain calcium supplement can drag down dolutegravir levels, which makes this HIV combination (dolutegravir, emtricitabine, and tenofovir alafenamide) one where I want people genuinely careful about what they add. Steady drug levels are what keep the virus suppressed, and 7 of the 107 interacting ingredients on file rate major, alongside 84 moderate and 16 minor. St. John's wort can push levels down too, and iron behaves like calcium, so space those doses well apart from the pill.

The largest cluster on the list touches the liver: 38 ingredients can raise the odds of liver damage, with beer and wine among the majors and herbs like ashwagandha in the same group. Six more can add kidney risk, and 17 can keep oral medicines from absorbing properly, activated charcoal chief among them. Understand the seven majors before deciding what else belongs alongside this regimen.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 84 Minor 16 No known interaction 1,345

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dolutegravir, Emtricitabine, Tenofovir alafenamide: Top Interactions at a Glance

The most significant Dolutegravir, Emtricitabine, Tenofovir alafenamide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 107 interacting ingredients — plus 1,345 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dolutegravir, Emtricitabine, Tenofovir alafenamide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Calcium + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

Calcium seems to reduce levels of dolutegravir.

Read the full interaction Major Likelihood Probable St. John's Wort + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

St.

Read the full interaction Major Likelihood Probable Wine + Dolutegravir, Emtricitabine, Tenofovir alafenamidei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Dolutegravir, Emtricitabine, Tenofovir alafenamide

All 1,452 ingredients in our database, ranked by severity — 107 with a Dolutegravir, Emtricitabine, Tenofovir alafenamide interaction on file and 1,345 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dolutegravir, Emtricitabine, Tenofovir alafenamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin A with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Moringa with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Mountain Ash with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Neem with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Neem + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Niacin with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Noni with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Oregon Grape with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Ostarine with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Padang Cassia with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Quercetin with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

Full Quercetin + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Rabdosia Rubescens with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Rabdosia rubescens might increase levels of p-glycoprotein substrates.

Full Rabdosia Rubescens + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Red Yeast Rice with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Rhodiola with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Rhubarb with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Sage with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Saigon Cinnamon with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Schisandra with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Slippery Elm with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Spearmint with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer

Can you take Strawberry with Dolutegravir, Emtricitabine, Tenofovir alafenamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Dolutegravir, Emtricitabine, Tenofovir alafenamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dolutegravir, Emtricitabine, Tenofovir alafenamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dolutegravir, Emtricitabine, Tenofovir alafenamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dolutegravir, Emtricitabine, Tenofovir alafenamide sits in 8 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Dolutegravir (Tivicay) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Nucleoside Reverse Transcriptase Inhibitors (Nrtis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Dolutegravir, Emtricitabine, Tenofovir alafenamide through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dolutegravir, Emtricitabine, Tenofovir alafenamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dolutegravir, Emtricitabine, Tenofovir alafenamide.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Dolutegravir, Emtricitabine, Tenofovir alafenamide & Supplements: Common Questions

What supplements interact with Dolutegravir, Emtricitabine, Tenofovir alafenamide?
More than you might expect — 107 in total, though they are far from equal: 7 are rated major, 84 moderate, and 16 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Dolutegravir, Emtricitabine, Tenofovir alafenamide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Calcium and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Dolutegravir, Emtricitabine, Tenofovir alafenamide?
Usually yes — most people on Dolutegravir, Emtricitabine, Tenofovir alafenamide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Dolutegravir, Emtricitabine, Tenofovir Alafenamide have the same supplement interactions as Dolutegravir, Emtricitabine, Tenofovir alafenamide?
Yes — Dolutegravir, Emtricitabine, Tenofovir Alafenamide all contain Dolutegravir, Emtricitabine, Tenofovir alafenamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dolutegravir, Emtricitabine, Tenofovir alafenamide and my other medications?
This page covers Dolutegravir, Emtricitabine, Tenofovir alafenamide against supplements and herbal ingredients. Checking Dolutegravir, Emtricitabine, Tenofovir alafenamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 29, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.