Medication interaction hub

What Supplements Interact with Epcoritamab-bysp?

Epcoritamab-bysp brand name: Epkinly. Every interaction below applies to the brands too.

53 Interactions 52 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Epcoritamab-bysp? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Epcoritamab-bysp against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you are receiving epcoritamab-bysp (Epkinly) for lymphoma, all 53 supplements on this page interact in essentially the same way: they can stimulate the immune system, which may interfere with how this treatment is meant to work. None of the 53 is rated major. Fifty-two sit at moderate and one at minor, so this is a watch-and-report list, not a wall of hard stops, but you should know what you are taking and why. Echinacea and ashwagandha are the two I most often find on patients' shelves.

Most of the evidence here is theoretical, drawn from lab and animal research rather than firm human trials. Still, with a cancer therapy this important, a supplement that quietly shifts immune activity is not a risk worth taking on your own. Bring the full list of what you swallow to your oncology team and let them weigh each one.

— , Clinical Pharmacist · July 18, 2026

Moderate 52 Minor 1 No known interaction 1,399

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Epcoritamab-bysp: Top Interactions at a Glance

The most significant Epcoritamab-bysp supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 53 interacting ingredients — plus 1,399 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Epcoritamab-bysp + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Active Hexose Correlated Compound (ahcc) + Epcoritamab-byspi

Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Read the full interaction Moderate Likelihood Possible Alfalfa + Epcoritamab-byspi

Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible American Ginseng + Epcoritamab-byspi

Theoretically, American ginseng use might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Andrographis + Epcoritamab-byspi

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Epcoritamab-byspi

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Read the full interaction Moderate Likelihood Possible Astragalus + Epcoritamab-byspi

Theoretically, astragalus might interfere with immunosuppressive therapy.

Read the full interaction
The complete list

Every Supplement Checked Against Epcoritamab-bysp

All 1,452 ingredients in our database, ranked by severity — 53 with a Epcoritamab-bysp interaction on file and 1,399 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Epcoritamab-bysp?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Trichopus Zeylanicus with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Trichopus zeylanicus might reduce the effects of immunosuppressants.

Full Trichopus Zeylanicus + Epcoritamab-bysp answer

Can you take Andrographis with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Full Andrographis + Epcoritamab-bysp answer

Can you take Shark Cartilage with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shark cartilage might interfere with immunosuppressive therapy.

Full Shark Cartilage + Epcoritamab-bysp answer

Can you take Picrorhiza with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Picrorhiza seems to have immunostimulating activity.

Full Picrorhiza + Epcoritamab-bysp answer

Can you take Quillaia with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quillaia with immunosuppressant drugs might decrease the effectiveness of these drugs.

Full Quillaia + Epcoritamab-bysp answer

Can you take Rhodiola with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola use might interfere with immunosuppressive therapy.

Full Rhodiola + Epcoritamab-bysp answer

Can you take Rice Bran Arabinoxylan Compound with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system.

Full Rice Bran Arabinoxylan Compound + Epcoritamab-bysp answer

Can you take Selenium with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.

Full Selenium + Epcoritamab-bysp answer

Can you take Shiitake Mushroom with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Full Shiitake Mushroom + Epcoritamab-bysp answer

Can you take Thuja with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja might stimulate immune function.

Full Thuja + Epcoritamab-bysp answer

Can you take Thunder God Vine with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might enhance the effects of immunosuppressant drugs.

Full Thunder God Vine + Epcoritamab-bysp answer

Can you take Thymus Extract with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, patients taking immunosuppressants may be at an increased risk of infection from contaminated thymus extract.

Full Thymus Extract + Epcoritamab-bysp answer

Can you take Tinospora Cordifolia with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might reduce the effectiveness of immunosuppressants.

Full Tinospora Cordifolia + Epcoritamab-bysp answer

Can you take Umckaloabo with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Pelargonium sidoides might decrease the effectiveness of immunosuppressant therapy.

Full Umckaloabo + Epcoritamab-bysp answer

Can you take Lychee with Epcoritamab-bysp?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, lychee might reduce the effectiveness of immunosuppressant drugs.

Full Lychee + Epcoritamab-bysp answer

Can you take Active Hexose Correlated Compound (ahcc) with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking AHCC might decrease the effects of immunosuppressant drugs.

Full Active Hexose Correlated Compound (ahcc) + Epcoritamab-bysp answer

Can you take Alfalfa with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.

Full Alfalfa + Epcoritamab-bysp answer

Can you take American Ginseng with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, American ginseng use might interfere with immunosuppressive therapy.

Full American Ginseng + Epcoritamab-bysp answer

Can you take Ashwagandha with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Full Ashwagandha + Epcoritamab-bysp answer

Can you take Astragalus with Epcoritamab-bysp?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astragalus might interfere with immunosuppressive therapy.

Full Astragalus + Epcoritamab-bysp answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Epcoritamab-bysp is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Epcoritamab-bysp, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Epcoritamab-bysp sits in 1 interaction category. Open any one to see what the group means:

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Epcoritamab-bysp through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Epcoritamab-bysp

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Epcoritamab-bysp.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Epcoritamab-bysp & Supplements: Common Questions

What supplements interact with Epcoritamab-bysp?
Our database currently documents 53 ingredients with a known Epcoritamab-bysp interaction (0 major, 52 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 53. The highest-ranked right now: Active Hexose Correlated Compound (ahcc), Alfalfa, American Ginseng.
Which Epcoritamab-bysp supplement interactions are the most serious?
None of the Epcoritamab-bysp supplement interactions on file are currently rated major. The most significant are the 52 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Epcoritamab-bysp?
Plenty of supplements coexist fine with Epcoritamab-bysp; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Epkinly have the same supplement interactions as Epcoritamab-bysp?
Yes — Epkinly all contain Epcoritamab-bysp, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Epcoritamab-bysp and my other medications?
This page covers Epcoritamab-bysp against supplements and herbal ingredients. Checking Epcoritamab-bysp against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.