Medication interaction hub

What Supplements Interact with Ephedrine, Guaifenesin (OTC drug)?

Ephedrine, Guaifenesin (OTC drug) brand names: Ephedrine Formula 400, Ephedrine Plus Tabs. Every interaction below applies to the brands too.

62 Interactions 15 Major 34 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 28, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ephedrine, Guaifenesin (OTC drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ephedrine, Guaifenesin (OTC drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

62 supplements and herbal ingredients have interactions with Ephedrine, Guaifenesin (OTC drug) on file in the HelloPharmacist interaction database — 15 rated major, 34 moderate, and 13 minor. The most serious involve Activated Charcoal, Black Tea, Caffeine, Coffee and Ephedra.

Our assessment: with 15 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ephedrine, Guaifenesin (OTC drug).

Major 15 Moderate 34 Minor 13 No known interaction 1,390

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ephedrine, Guaifenesin (OTC drug): Top Interactions at a Glance

The Ephedrine, Guaifenesin (OTC drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 62 interacting ingredients — plus 1,390 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ephedrine, Guaifenesin (OTC drug) Combinations Today

The Ephedrine, Guaifenesin (OTC drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Caffeine + Ephedrine, Guaifenesin (OTC drug)i

Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Read the full interaction Major Likelihood Probable Green Tea + Ephedrine, Guaifenesin (OTC drug)i

Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Read the full interaction Major Likelihood Probable Guarana + Ephedrine, Guaifenesin (OTC drug)i

Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Read the full interaction Major Likelihood Probable Coffee + Ephedrine, Guaifenesin (OTC drug)i

Theoretically, concomitant use might increase the risk of stimulant adverse effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ephedrine, Guaifenesin (OTC drug)i

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Black Tea + Ephedrine, Guaifenesin (OTC drug)i

Theoretically, concomitant use might increase the risk for simulant adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ephedrine, Guaifenesin (OTC drug)

All 1,452 ingredients in our database, ranked by severity — 62 with a Ephedrine, Guaifenesin (OTC drug) interaction on file and 1,390 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ephedrine, Guaifenesin (OTC drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Caffeine with Ephedrine, Guaifenesin (OTC drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Full Caffeine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Green Tea with Ephedrine, Guaifenesin (OTC drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Full Green Tea + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Guarana with Ephedrine, Guaifenesin (OTC drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk for stimulant adverse effects.

Full Guarana + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Coffee with Ephedrine, Guaifenesin (OTC drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk of stimulant adverse effects.

Full Coffee + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Dimethylhexylamine (dmha) with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Ergot with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Co-administration of stimulant drugs with ergot may increase the risk of vasoconstriction.

Full Ergot + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Guar Gum with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Gum Arabic with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Higenamine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the risk of cardiovascular toxicity when taken with stimulant drugs.

Full Higenamine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Hordenine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Isopropylnorsynephrine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascula...

Full Isopropylnorsynephrine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Khat with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Methylsynephrine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Panax Ginseng with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with stimulant drugs might increase the risk of adverse stimulant effects.

Full Panax Ginseng + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Phenpromethamine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Raspberry Ketone with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Rauwolscine with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.

Full Rauwolscine + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Securinega Suffruticosa with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Slippery Elm with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Ephedrine, Guaifenesin (OTC drug) answer

Can you take Tragacanth with Ephedrine, Guaifenesin (OTC drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Ephedrine, Guaifenesin (OTC drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ephedrine, Guaifenesin (OTC drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ephedrine, Guaifenesin (OTC drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ephedrine, Guaifenesin (OTC drug) sits in 4 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Ephedrine, Guaifenesin (OTC drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ephedrine, Guaifenesin (OTC drug) through this category.

Ephedrine 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Ephedrine, Guaifenesin (OTC drug) through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ephedrine, Guaifenesin (OTC drug) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ephedrine, Guaifenesin (OTC drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ephedrine, Guaifenesin (OTC drug).

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Pharmacist Counseling Corner

Ephedrine, Guaifenesin (OTC drug) & Supplements: Common Questions

What supplements interact with Ephedrine, Guaifenesin (OTC drug)?
In our interaction database, 62 supplement and herbal ingredients have an interaction with Ephedrine, Guaifenesin (OTC drug) on file — 15 rated major, 34 moderate, and 13 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Black Tea, Caffeine.
Which Ephedrine, Guaifenesin (OTC drug) supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Black Tea, Caffeine, Coffee and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ephedrine, Guaifenesin (OTC drug)?
That depends entirely on which supplement. The honest answer for Ephedrine, Guaifenesin (OTC drug) is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Ephedrine Formula 400 have the same supplement interactions as Ephedrine, Guaifenesin (OTC drug)?
Yes — Ephedrine Formula 400, Ephedrine Plus Tabs all contain Ephedrine, Guaifenesin (OTC drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ephedrine, Guaifenesin (OTC drug) and my other medications?
This page covers Ephedrine, Guaifenesin (OTC drug) against supplements and herbal ingredients. Checking Ephedrine, Guaifenesin (OTC drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 28, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.