Medication interaction hub

What Supplements Interact with Fluticasone Furoate, Vilanterol Trifenatate?

Fluticasone Furoate, Vilanterol Trifenatate brand name: Breo Ellipta. Every interaction below applies to the brands too.

172 Interactions 9 Major 126 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluticasone Furoate, Vilanterol Trifenatate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluticasone Furoate, Vilanterol Trifenatate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

172 supplements and herbal ingredients have interactions with Fluticasone Furoate, Vilanterol Trifenatate on file in the HelloPharmacist interaction database — 9 rated major, 126 moderate, and 37 minor. The most serious involve Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra.

Our assessment: with 9 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Fluticasone Furoate, Vilanterol Trifenatate.

Major 9 Moderate 126 Minor 37 No known interaction 1,280

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fluticasone Furoate, Vilanterol Trifenatate: Top Interactions at a Glance

The most significant Fluticasone Furoate, Vilanterol Trifenatate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 172 interacting ingredients — plus 1,280 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Fluticasone Furoate, Vilanterol Trifenatate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Fluticasone Furoate, Vilanterol Trifenatatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Fluticasone Furoate, Vilanterol Trifenatatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Fluticasone Furoate, Vilanterol Trifenatatei

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Fluticasone Furoate, Vilanterol Trifenatatei

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Fluticasone Furoate, Vilanterol Trifenatatei

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Lily-of-the-valley + Fluticasone Furoate, Vilanterol Trifenatatei

Theoretically, using lily-of-the-valley with prolonged corticosteroid therapy can cause cardiac glycoside toxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Fluticasone Furoate, Vilanterol Trifenatate

All 1,452 ingredients in our database, ranked by severity — 172 with a Fluticasone Furoate, Vilanterol Trifenatate interaction on file and 1,280 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluticasone Furoate, Vilanterol Trifenatate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Full Coffee + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take American Elder with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Calamus with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Butternut with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Butternut has stimulant laxative effects.

Full Butternut + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cannabis with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cascara Sagrada with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.

Full Cascara Sagrada + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cat's Claw with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Ceylon Leadwort with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Chanca Piedra with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Chokeberry with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cinchona with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Clove with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Coleus with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Corn Silk with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking corn silk with corticosteroids might increase the risk of hypokalemia.

Full Corn Silk + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Corydalis Yanhusuo with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cranberry with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Cubebs with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Danshen with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Devil's Claw with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Fluticasone Furoate, Vilanterol Trifenatate answer

Can you take Dhea with Fluticasone Furoate, Vilanterol Trifenatate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Fluticasone Furoate, Vilanterol Trifenatate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluticasone Furoate, Vilanterol Trifenatate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluticasone Furoate, Vilanterol Trifenatate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluticasone Furoate, Vilanterol Trifenatate sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fluticasone Furoate, Vilanterol Trifenatate through this category.

Corticosteroids 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Fluticasone Furoate, Vilanterol Trifenatate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fluticasone Furoate, Vilanterol Trifenatate through this category.

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Fluticasone Furoate, Vilanterol Trifenatate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Fluticasone Furoate, Vilanterol Trifenatate through this category.

About Fluticasone Furoate, Vilanterol Trifenatate

Fluticasone and vilanterol is an inhaled combination of a corticosteroid and a long-acting bronchodilator used for the maintenance treatment of COPD and asthma.

Generic name: Fluticasone Furoate, Vilanterol Trifenatate  ·  Brand name: Breo Ellipta.

See the full Fluticasone and Vilanterol Oral Inhalation drug information

Related: does Fluticasone Furoate, Vilanterol Trifenatate deplete any nutrients?

Fluticasone Furoate, Vilanterol Trifenatate has 8 reported nutrient associations in the research literature — see the Fluticasone Furoate, Vilanterol Trifenatate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluticasone Furoate, Vilanterol Trifenatate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluticasone Furoate, Vilanterol Trifenatate.

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Pharmacist Counseling Corner

Fluticasone Furoate, Vilanterol Trifenatate & Supplements: Common Questions

What supplements interact with Fluticasone Furoate, Vilanterol Trifenatate?
More than you might expect — 172 in total, though they are far from equal: 9 are rated major, 126 moderate, and 37 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Fluticasone Furoate, Vilanterol Trifenatate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fluticasone Furoate, Vilanterol Trifenatate?
Usually yes — most people on Fluticasone Furoate, Vilanterol Trifenatate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Breo Ellipta have the same supplement interactions as Fluticasone Furoate, Vilanterol Trifenatate?
Yes — Breo Ellipta all contain Fluticasone Furoate, Vilanterol Trifenatate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Fluticasone Furoate, Vilanterol Trifenatate deplete any vitamins or nutrients?
It might — Fluticasone Furoate, Vilanterol Trifenatate has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Fluticasone Furoate, Vilanterol Trifenatate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Fluticasone Furoate, Vilanterol Trifenatate and my other medications?
This page covers Fluticasone Furoate, Vilanterol Trifenatate against supplements and herbal ingredients. Checking Fluticasone Furoate, Vilanterol Trifenatate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fluticasone and Vilanterol Oral Inhalation drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.