Medication interaction hub

What Supplements Interact with Lactic Acid, Citric Acid, Potassium Bitartrate?

Lactic Acid, Citric Acid, Potassium Bitartrate brand name: Phexxi. Every interaction below applies to the brands too.

33 Interactions 1 Major 21 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lactic Acid, Citric Acid, Potassium Bitartrate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lactic Acid, Citric Acid, Potassium Bitartrate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort is the entry I would not brush past. Phexxi, the vaginal contraceptive gel of lactic acid, citric acid, and potassium bitartrate, has one job, preventing pregnancy, and St. John's wort carries this list's only major rating because it speeds the body's clearance of contraceptive drugs and can leave users underprotected. Thirty of the 33 supplements and herbs on file interact through contraceptive effects, so this is a list to read carefully rather than skim.

Most of the 21 moderate entries involve plant compounds with estrogen-like or estrogen-blocking activity, while several are caffeine sources like coffee, since contraceptive drugs slow caffeine clearance by 40 to 65 percent and a usual cup can hit harder. Three others, including DMSO, can increase absorption of medicines applied to the skin, relevant for a gel. The remaining 11 rate minor. Anyone taking St. John's wort alongside Phexxi should add a backup method until the overlap ends.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 21 Minor 11 No known interaction 1,419

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Lactic Acid, Citric Acid, Potassium Bitartrate: Top Interactions at a Glance

The most significant Lactic Acid, Citric Acid, Potassium Bitartrate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 33 interacting ingredients — plus 1,419 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Lactic Acid, Citric Acid, Potassium Bitartrate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable St. John's Wort + Lactic Acid, Citric Acid, Potassium Bitartratei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Lactic Acid, Citric Acid, Potassium Bitartrate

All 1,452 ingredients in our database, ranked by severity — 33 with a Lactic Acid, Citric Acid, Potassium Bitartrate interaction on file and 1,419 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lactic Acid, Citric Acid, Potassium Bitartrate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yerba Mate with Lactic Acid, Citric Acid, Potassium Bitartrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, contraceptive drugs might increase the levels and adverse effects of the caffeine contained in yerba mate.

Full Yerba Mate + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Copper with Lactic Acid, Citric Acid, Potassium Bitartrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Deer Velvet with Lactic Acid, Citric Acid, Potassium Bitartrate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.

Full Deer Velvet + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take St. John's Wort with Lactic Acid, Citric Acid, Potassium Bitartrate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Black Tea with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in black tea.

Full Black Tea + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Coffee with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in coffee.

Full Coffee + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Fish Oil with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.

Full Fish Oil + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Fo-ti with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fo-ti might interfere with contraceptive drugs due to competition for estrogen receptors.

Full Fo-ti + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Green Coffee with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green coffee.

Full Green Coffee + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Green Tea with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green tea.

Full Green Tea + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Ilex Guayusa with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in Ilex guayusa.

Full Ilex Guayusa + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Melatonin with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.

Full Melatonin + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Activated Charcoal with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Activated charcoal may reduce the clinical effects of oral contraceptives.

Full Activated Charcoal + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Alfalfa with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might interfere with the activity of contraceptive drugs.

Full Alfalfa + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Anise with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise might interfere with contraceptive drug therapy.

Full Anise + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Chrysin with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.

Full Chrysin + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Dimethylsulfoxide (dmso) with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Equol with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, equol might increase the levels and clinical effects of ethinyl estradiol found in contraceptive drugs.

Full Equol + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take Fennel with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Full Fennel + Lactic Acid, Citric Acid, Potassium Bitartrate answer

Can you take German Chamomile with Lactic Acid, Citric Acid, Potassium Bitartrate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.

Full German Chamomile + Lactic Acid, Citric Acid, Potassium Bitartrate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lactic Acid, Citric Acid, Potassium Bitartrate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lactic Acid, Citric Acid, Potassium Bitartrate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lactic Acid, Citric Acid, Potassium Bitartrate sits in 2 interaction categories. Open any one to see what the group means:

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Lactic Acid, Citric Acid, Potassium Bitartrate through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Lactic Acid, Citric Acid, Potassium Bitartrate through this category.

About Lactic Acid, Citric Acid, Potassium Bitartrate

PHEXXI is a hormone-free vaginal gel used right before sex to prevent pregnancy by keeping sperm from moving normally.

Generic name: Lactic Acid, Citric Acid, Potassium Bitartrate  ·  Brand name: Phexxi.

See the full Lactic Acid, Citric Acid, and Potassium Bitartrate Vaginal Contraceptive drug information

Related: does Lactic Acid, Citric Acid, Potassium Bitartrate deplete any nutrients?

Lactic Acid, Citric Acid, Potassium Bitartrate has 2 reported nutrient associations in the research literature — see the Lactic Acid, Citric Acid, Potassium Bitartrate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lactic Acid, Citric Acid, Potassium Bitartrate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lactic Acid, Citric Acid, Potassium Bitartrate.

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Pharmacist Counseling Corner

Lactic Acid, Citric Acid, Potassium Bitartrate & Supplements: Common Questions

What supplements interact with Lactic Acid, Citric Acid, Potassium Bitartrate?
In our interaction database, 33 supplement and herbal ingredients have an interaction with Lactic Acid, Citric Acid, Potassium Bitartrate on file — 1 rated major, 21 moderate, and 11 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: St. John's Wort, Black Tea, Coffee.
Which Lactic Acid, Citric Acid, Potassium Bitartrate supplement interactions are the most serious?
The 1 major-rated combination — led by St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lactic Acid, Citric Acid, Potassium Bitartrate?
That depends entirely on which supplement. The honest answer for Lactic Acid, Citric Acid, Potassium Bitartrate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Phexxi have the same supplement interactions as Lactic Acid, Citric Acid, Potassium Bitartrate?
Yes — Phexxi all contain Lactic Acid, Citric Acid, Potassium Bitartrate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lactic Acid, Citric Acid, Potassium Bitartrate deplete any vitamins or nutrients?
It might — Lactic Acid, Citric Acid, Potassium Bitartrate has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lactic Acid, Citric Acid, Potassium Bitartrate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lactic Acid, Citric Acid, Potassium Bitartrate and my other medications?
This page covers Lactic Acid, Citric Acid, Potassium Bitartrate against supplements and herbal ingredients. Checking Lactic Acid, Citric Acid, Potassium Bitartrate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lactic Acid, Citric Acid, and Potassium Bitartrate Vaginal Contraceptive drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.