Medication interaction hub

What Supplements Interact with Lithium Carbonate (prescription drug)?

Lithium Carbonate (prescription drug) brand names: Eskalith, Lithium Carbonate. Every interaction below applies to the brands too.

189 Interactions 12 Major 163 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lithium Carbonate (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lithium Carbonate (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lithium carbonate (Eskalith) steadies mood in bipolar disorder, but it works within a narrow blood-level window, meaning a small shift up risks toxicity and a shift down risks relapse. The 189 supplements and herbs listed here therefore call for genuine vigilance. The largest cluster, 78 ingredients including kava and alcohol, deepens sedation, while another 76, many with diuretic effects, can change how much lithium actually stays in your blood.

Learn the 12 major-rated entries first; the other 163 rate moderate and 14 minor. Some of those majors, Siberian cocklebur among them, put extra strain on the kidneys, which already do the work of clearing lithium. Fiber such as psyllium can blunt lithium absorption when swallowed at the same time, so space the doses well apart. And 20 serotonergic ingredients can push serotonin higher alongside lithium, raising the risk of serotonin syndrome, a reaction marked by agitation, sweating, and confusion.

— , Clinical Pharmacist · July 18, 2026

Major 12 Moderate 163 Minor 14 No known interaction 1,263

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lithium Carbonate (prescription drug): Top Interactions at a Glance

The Lithium Carbonate (prescription drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 189 interacting ingredients — plus 1,263 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lithium Carbonate (prescription drug) Combinations Today

The Lithium Carbonate (prescription drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible German Chamomile + Lithium Carbonate (prescription drug)i

Theoretically, German chamomile might have additive effects when used with CNS depressants.

Read the full interaction Moderate Likelihood Possible Acetyl-l-carnitine + Lithium Carbonate (prescription drug)i

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, wh...

Read the full interaction Moderate Likelihood Probable Caffeine + Lithium Carbonate (prescription drug)i

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.

Read the full interaction Moderate Likelihood Possible Corydalis Yanhusuo + Lithium Carbonate (prescription drug)i

Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Probable Iodine + Lithium Carbonate (prescription drug)i

Combining iodine with lithium might have additive hypothyroid effects.

Read the full interaction Moderate Likelihood Possible St. John's Wort + Lithium Carbonate (prescription drug)i

Theoretically, St.

Read the full interaction
The complete list

Every Supplement Checked Against Lithium Carbonate (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 189 with a Lithium Carbonate (prescription drug) interaction on file and 1,263 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lithium Carbonate (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take German Chamomile with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Lithium Carbonate (prescription drug) answer

Can you take Acetyl-l-carnitine with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + Lithium Carbonate (prescription drug) answer

Can you take Caffeine with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.

Full Caffeine + Lithium Carbonate (prescription drug) answer

Can you take Corydalis Yanhusuo with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Lithium Carbonate (prescription drug) answer

Can you take Iodine with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining iodine with lithium might have additive hypothyroid effects.

Full Iodine + Lithium Carbonate (prescription drug) answer

Can you take Uva Ursi with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.

Full Uva Ursi + Lithium Carbonate (prescription drug) answer

Can you take Water Hemlock with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Water hemlock is thought to have diuretic properties.

Full Water Hemlock + Lithium Carbonate (prescription drug) answer

Can you take Watercress with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Watercress is thought to have diuretic properties.

Full Watercress + Lithium Carbonate (prescription drug) answer

Can you take White Pepper with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. White pepper is thought to have diuretic properties.

Full White Pepper + Lithium Carbonate (prescription drug) answer

Can you take White Sandalwood with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking white sandalwood might reduce lithium excretion and increase serum levels of lithium.

Full White Sandalwood + Lithium Carbonate (prescription drug) answer

Can you take Wild Carrot with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Wild carrot is thought to have diuretic properties.

Full Wild Carrot + Lithium Carbonate (prescription drug) answer

Can you take Winter Savory with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Winter savory is thought to have diuretic properties.

Full Winter Savory + Lithium Carbonate (prescription drug) answer

Can you take Yarrow with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.

Full Yarrow + Lithium Carbonate (prescription drug) answer

Can you take Yerba Mansa with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Lithium Carbonate (prescription drug) answer

Can you take Yerba Mate with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, abrupt withdrawal of the caffeine in yerba mate might increase serum lithium levels.

Full Yerba Mate + Lithium Carbonate (prescription drug) answer

Can you take Yerba Santa with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Yerba santa is thought to have diuretic properties.

Full Yerba Santa + Lithium Carbonate (prescription drug) answer

Can you take 5-htp with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Lithium Carbonate (prescription drug) answer

Can you take Adrue with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold comp...

Full Adrue + Lithium Carbonate (prescription drug) answer

Can you take Albizia Julibrissin with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Lithium Carbonate (prescription drug) answer

Can you take Apple with Lithium Carbonate (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that concomitant consumption of apple juice might decrease oral absorption and blood levels of lithium.

Full Apple + Lithium Carbonate (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lithium Carbonate (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lithium Carbonate (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lithium Carbonate (prescription drug) sits in 7 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Lithium 76 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

76 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Lithium Carbonate (prescription drug) through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Lithium Carbonate (prescription drug) through this category.

About Lithium Carbonate (prescription drug)

Lithium is an antimanic agent used to treat and prevent manic episodes in people with bipolar disorder.

Generic name: Lithium Carbonate (prescription drug)  ·  Brand names: Eskalith, Lithium Carbonate.

See the full Lithium drug information

Related: does Lithium Carbonate (prescription drug) deplete any nutrients?

Lithium Carbonate (prescription drug) has 2 reported nutrient associations in the research literature — see the Lithium Carbonate (prescription drug) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lithium Carbonate (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lithium Carbonate (prescription drug).

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Products that contain Lithium Carbonate (prescription drug)-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Lithium Carbonate (prescription drug).

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Lithium Carbonate (prescription drug) & Supplements: Common Questions

What supplements interact with Lithium Carbonate (prescription drug)?
More than you might expect — 189 in total, though they are far from equal: 12 are rated major, 163 moderate, and 14 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Lithium Carbonate (prescription drug) supplement interactions are the most serious?
The 12 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Lithium Carbonate (prescription drug)?
Usually yes — most people on Lithium Carbonate (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Eskalith have the same supplement interactions as Lithium Carbonate (prescription drug)?
Yes — Eskalith, Lithium Carbonate all contain Lithium Carbonate (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lithium Carbonate (prescription drug) deplete any vitamins or nutrients?
It might — Lithium Carbonate (prescription drug) has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lithium Carbonate (prescription drug) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lithium Carbonate (prescription drug) and my other medications?
This page covers Lithium Carbonate (prescription drug) against supplements and herbal ingredients. Checking Lithium Carbonate (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lithium drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.