Hydrangea + Lithium Carbonate (prescription drug)
Lithium Carbonate (prescription drug) brand names: Eskalith, Lithium Carbonate.
Hydrangea has a moderate interaction with Lithium Carbonate (prescription drug). Hydrangea is thought to have diuretic properties.
Read the full interaction reportHydrangea and Lithium Carbonate (prescription drug)
Here is the interaction we found between these two, with the evidence behind it.
LITHIUM
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the concern with combining hydrangea root and your lithium. Lithium isn't broken down by the liver, instead your kidneys clear it out through your urine. Hydrangea is thought to act like a mild water pill (a diuretic), and anything that changes how your kidneys handle fluid and salt can shift how much lithium stays in your body. The worry is that lithium levels could creep up.
That matters because lithium has a very narrow safe range. Even small increases can tip you toward toxicity, with signs like nausea, hand tremors, unusual drowsiness, confusion, or trouble with balance. I want to be honest though: this is a theoretical concern based on pharmacology, not proven in studies. Still, with a drug this finicky, please check with your doctor or pharmacist before adding hydrangea.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Questions About Hydrangea or Lithium Carbonate (prescription drug)
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hydrangea or Lithium Carbonate (prescription drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Lithium Carbonate (prescription drug)
This page covers Hydrangea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lithium Carbonate (prescription drug) page lists 189 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).
By severity: 12 major · 163 moderate · 14 minor.
From our pharmacist’s overview on the Lithium Carbonate (prescription drug) page
“Lithium carbonate (Eskalith) steadies mood in bipolar disorder, but it works within a narrow blood-level window, meaning a small shift up risks toxicity and a shift down risks relapse. The 189 supplements and herbs listed here therefore call for genuine vigilance.”
Reviewed by 2 · Jul 18, 2026
Open the Lithium Carbonate (prescription drug) interaction page
Taking Hydrangea as Part of a Dietary Supplement Product? Check It for Interactions
We hold 337 real supplement products containing Hydrangea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hydrangea. Your product may carry other ingredients that interact with Lithium Carbonate (prescription drug) too, on top of Hydrangea — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Hydrangea and Lithium Carbonate (prescription drug) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#332 of 1,452 supplements looked up here in the last 7 days
#1,037 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Hydrangea
What is Hydrangea?
- Kidney and bladder stones
- Urinary tract complaints
- Enlarged prostate symptoms
- Mild diuretic (increasing urine)
- Bladder infections (traditional use)
Hydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Because safety data are limited and large amounts may be harmful, it is best to talk with a pharmacist or doctor before using it.
About Lithium
What Is Lithium Used For?
Brand names: Eskalith, Lithium Carbonate
Lithium is used to treat acute manic and mixed episodes in bipolar I disorder and as maintenance therapy to reduce how often and how severely manic episodes return. It is approved for adults and children ages 7 and older.
Lithium Carbonate capsules, tablets, and extended-release tablets, as well as Lithium oral solution, are all indicated for these uses in bipolar I disorder. Maintenance therapy with lithium helps prevent future episodes or makes them less intense when they do occur.
Other Drugs & Hydrangea
Browse every other medication we’ve checked against Hydrangea — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Hydrangea against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Clopidogrel ›
- Escitalopram ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Amoxicillin ›
- Methotrexate ›
- Isotretinoin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bendamustine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hydrangea list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Lithium Carbonate (prescription drug) Is Linked to Lower Levels of One Nutrient
Natural Medicines records Lithium Carbonate (prescription drug) as a medicine that can lower these. This is not an interaction with Hydrangea — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Lithium Carbonate (prescription drug) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Hydrangea and Lithium Carbonate (prescription drug) Together: Common Questions
Can you take Hydrangea with Lithium Carbonate (prescription drug)?
How serious is the Hydrangea and Lithium Carbonate (prescription drug) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Lithium Carbonate (prescription drug) and Hydrangea?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.