Medication interaction hub

What Supplements Interact with Phenylephrine, Tropicamide?

Phenylephrine, Tropicamide brand name: Mydcombi. Every interaction below applies to the brands too.

34 Interactions 2 Major 29 Moderate 3 Minor
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Phenylephrine, Tropicamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Phenylephrine, Tropicamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mydcombi, the phenylephrine and tropicamide spray used to dilate pupils for eye exams, seems like a one-time thing, but enough of it reaches the bloodstream to matter, and the 34 supplement ingredients on this list call for real care before your appointment. Thirty of them act on tropicamide's anticholinergic side, either piling on its effects (dry mouth, racing heart, confusion) or working against them. The two rated major, henbane and scopolia, contain the same atropine-like alkaloids as the medication itself, so combining them can stack the effect hard.

Most of the 29 moderate entries carry that additive risk in smaller measure, though a few memory herbs do the opposite, raising acetylcholine in ways that could blunt the dilation. Three topical products, DMSO among them, can pull medicines applied to the skin or eyes in faster, and one herb mimics phenylephrine's blood-vessel-tightening action; the three minor entries barely register by comparison. Set aside the alkaloid-heavy botanicals around your exam, and tell whoever dilates your eyes what you take.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 29 Minor 3 No known interaction 1,418

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Phenylephrine, Tropicamide: Top Interactions at a Glance

The most significant Phenylephrine, Tropicamide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 34 interacting ingredients — plus 1,418 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Phenylephrine, Tropicamide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Henbane + Phenylephrine, Tropicamidei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Scopolia + Phenylephrine, Tropicamidei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Phenylephrine, Tropicamide

All 1,452 ingredients in our database, ranked by severity — 34 with a Phenylephrine, Tropicamide interaction on file and 1,418 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Phenylephrine, Tropicamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bacopa with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might decrease the effectiveness of both agents.

Full Bacopa + Phenylephrine, Tropicamide answer

Can you take Boxwood with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Phenylephrine, Tropicamide answer

Can you take Butcher's Broom with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.

Full Butcher's Broom + Phenylephrine, Tropicamide answer

Can you take Calamus with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and calamus might decrease the effectiveness of the anticholinergic drug.

Full Calamus + Phenylephrine, Tropicamide answer

Can you take Clubmoss with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Full Clubmoss + Phenylephrine, Tropicamide answer

Can you take Corkwood Tree with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, corkwood tree might increase the risk of adverse anticholinergic effects when taken with anticholinergic drugs.

Full Corkwood Tree + Phenylephrine, Tropicamide answer

Can you take Dimethylsulfoxide (dmso) with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Phenylephrine, Tropicamide answer

Can you take European Barberry with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.

Full European Barberry + Phenylephrine, Tropicamide answer

Can you take European Mandrake with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concurrent use may cause additive anticholinergic effects and adverse effects.

Full European Mandrake + Phenylephrine, Tropicamide answer

Can you take Huperzine A with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, huperzine A might decrease the effects of anticholinergic drugs.

Full Huperzine A + Phenylephrine, Tropicamide answer

Can you take Iboga with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga might decrease the effectiveness of anticholinergic drugs.

Full Iboga + Phenylephrine, Tropicamide answer

Can you take Jimson Weed with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jimson weed may increase anticholinergic effects and adverse effects.

Full Jimson Weed + Phenylephrine, Tropicamide answer

Can you take Marjoram with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity.

Full Marjoram + Phenylephrine, Tropicamide answer

Can you take Methylene Blue with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Methylene Blue + Phenylephrine, Tropicamide answer

Can you take Nutmeg with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.

Full Nutmeg + Phenylephrine, Tropicamide answer

Can you take Phosphatidylserine with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.

Full Phosphatidylserine + Phenylephrine, Tropicamide answer

Can you take Poria Mushroom with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.

Full Poria Mushroom + Phenylephrine, Tropicamide answer

Can you take Purple Nut Sedge with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, purple nut sedge dose-dependently inhibits acetylcholinesterase (AChE).

Full Purple Nut Sedge + Phenylephrine, Tropicamide answer

Can you take Sage with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might decrease the clinical effects of anticholinergic drugs.

Full Sage + Phenylephrine, Tropicamide answer

Can you take Syrian Rue with Phenylephrine, Tropicamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might decrease the effects of anticholinergic drugs.

Full Syrian Rue + Phenylephrine, Tropicamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Phenylephrine, Tropicamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Phenylephrine, Tropicamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Phenylephrine, Tropicamide sits in 3 interaction categories. Open any one to see what the group means:

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Phenylephrine, Tropicamide through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Phenylephrine, Tropicamide through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Phenylephrine, Tropicamide through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Phenylephrine, Tropicamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Phenylephrine, Tropicamide.

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Products that contain Phenylephrine, Tropicamide-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Phenylephrine, Tropicamide.

Calmhills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Angiplex by UNDA Plex contains Belladonna Back & Neck Pain by BIOVEA Homeopathics contains Belladonna SuperFlex-H by NewtonEverett contains Belladonna CBD+13 by T-Relief contains Belladonna
Pharmacist Counseling Corner

Phenylephrine, Tropicamide & Supplements: Common Questions

What supplements interact with Phenylephrine, Tropicamide?
More than you might expect — 34 in total, though they are far from equal: 2 are rated major, 29 moderate, and 3 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Henbane, Scopolia, Belladonna.
Which Phenylephrine, Tropicamide supplement interactions are the most serious?
Focus on the major group: Henbane and Scopolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Phenylephrine, Tropicamide?
Usually yes — most people on Phenylephrine, Tropicamide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Mydcombi have the same supplement interactions as Phenylephrine, Tropicamide?
Yes — Mydcombi all contain Phenylephrine, Tropicamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Phenylephrine, Tropicamide and my other medications?
This page covers Phenylephrine, Tropicamide against supplements and herbal ingredients. Checking Phenylephrine, Tropicamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.