Interactions on record — worth a quick check against your medications. Based on 9 of 16 ingredients. Check your meds →
Dietary supplement

SuperFlex-H Ingredients & Drug Interactions

by NewtonEverett

SuperFlex-H label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperFlex-H against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SuperFlex-H is a dietary supplement by NewtonEverett with 16 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 1,214 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Berberis vulgaris, Belladonna, Solidago. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SuperFlex-H by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperFlex-H by NewtonEverett — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SuperFlex-H by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 16 active ingredients.

SuperFlex-H is a liquid formula with 16 ingredients. The active ingredients include silica (silicon), goldenrod, poison ivy, bryonia, apis mellifica, natrum sulphuricum, ledum palustre, mountain laurel, bulbous buttercup, berberis vulgaris, belladonna, aurum metallicum, nat. phos, uricum acidum, glycerin, and alcohol.

Most of these are highly diluted homeopathic remedies; silica and glycerin are present in measurable amounts. There are no inactive fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Joint and muscle pain relief.
  • We looked for evidence on: Back pain, Osteoarthritis, Rheumatoid arthritis (RA), Sprains, Pain (acute), Muscle soreness — and 2 related terms.
  • The closest evidence on file: Poison Ivy is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Poison Ivy is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Pain (acute), Rheumatoid arthritis (RA), Sprains.
  • Also on file: Belladonna is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA).

The evidence for SuperFlex-H's ingredients is sparse. Silica is possibly effective for osteoporosis but has insufficient evidence for hair loss and dental support.

Glycerin is likely effective for constipation but the other uses are not well established. For the homeopathic ingredients—goldenrod, bryonia, poison ivy, mountain laurel, bulbous buttercup, and belladonna—we have no effectiveness ratings in our data.

The product's overall ability to address its intended purpose is not established by the evidence we hold.

The evidence, ingredient by ingredient Silicon Goldenrod Poison Ivy Bryonia Mountain Laurel Bulbous Buttercup European Barberry Belladonna

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product raises significant safety concerns. Belladonna is poisonous and should not be taken outside professionally supervised products—it can cause serious anticholinergic side effects like blurred vision, confusion, and delirium even at low doses.

Poison ivy, mountain laurel, bulbous buttercup, and bryonia are all toxic plants; while they are highly diluted in this formula, the safety data advises against their use during pregnancy and breastfeeding. Silica at high doses or long-term has not been well studied.

Glycerin in large oral doses may cause stomach upset and dehydration. Goldenrod can trigger allergic reactions, including contact dermatitis and in rare cases respiratory symptoms.

Side effects, ingredient by ingredient Silicon Goldenrod Poison Ivy Bryonia Mountain Laurel Bulbous Buttercup European Barberry Belladonna

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 9 matched ingredients can interact with medications — Goldenrod, European Barberry, Belladonna.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,215 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SuperFlex-H, double-check these medication types: anticholinergic drugs (belladonna increases their side effects), cisapride or similar gastrointestinal motility medications (belladonna may weaken them), and diuretics (goldenrod may boost their effects and unwanted effects).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains multiple toxic plant ingredients and belladonna, which is poisonous. It is not appropriate for use during pregnancy or while breastfeeding.

Because of its potent and toxic ingredients, you should only consider it under professional supervision, and you must check your medications against the interaction tool before use. Talk to your pharmacist or doctor before taking SuperFlex-H.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperFlex-H, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 818423027807
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213178
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperFlex-H by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Not Present
Maximum serving Sizes:
1 Not Present
UPC/BARCODE
818423027807
IngredientAmount% DV
Silica0 NP--
Solidago0 NP--
Rhus toxicodendron0 NP--
Bryonia0 NP--
Apis mellifica0 NP--
Natrum sulphuricum0 NP--
Ledum palustre0 NP--
Kalmia latifolia0 NP--
Ranunculus bulbosus0 NP--
Berberis vulgaris0 NP--
Belladonna0 NP--
Aurum Metallicum0 NP--
Nat. Phos0 NP--
Alcohol0 NP--
HPUS Uricum Acidum0 NP--
Glycerin0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Description: Homeopathic SuperFlex-H joint and muscle pain relief spray is a completely natural mixture of homeopathic ingredients that are designed to stop inflammation, pain and stiffness in the muscles and joints.

General Statements

SuperFlex-H joint and muscle pain relief is safe and has no side effects.

Suggested/Recommended/Usage/Directions

Directions: Spray 3 times under tongue, 3 times per day (morning, afternoon and evening). Take 5 days per week. May be sprayed on area of pain, then gently rubbed in.

Precautions

Do not eat or drink 20 minutes before or after taking product.

Warning: Do not use if pregnant or nursing.

Keep out of the reach of children.

Tamper resistant seal. Do not use if seal is broken or missing.

Formulation

Joint Care Formula

Homeopathic Oral Spray

Relieve joint pain Relieve muscle pain No side effects

Flexibility Comfort Mobility

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements are based upon traditional homeopathic practice. They have not been reviewed by the Food and Drug Administration.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperFlex-H by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperFlex-H label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperFlex-H by NewtonEverett

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Not Present Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Silica

No known
interactions
0 NP per serving

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silica monograph & interactions

Solidago

Interacts with
75 drugs
0 NP per serving

Goldenrod is a flowering plant traditionally used as an herbal diuretic and for urinary tract health. Human evidence is limited, and while it is gener...

Solidago monograph & interactions

Rhus toxicodendron

No known
interactions
0 NP per serving

Poison ivy is a toxic plant best known for causing an itchy, blistering allergic rash on contact. In supplement form it is sold almost exclusively as...

Rhus toxicodendron monograph & interactions

Bryonia

No known
interactions
0 NP per serving

Bryonia is a toxic climbing vine that is mainly used today in homeopathic dilutions for coughs, pain, and inflammation, but solid scientific evidence...

Bryonia monograph & interactions

Apis mellifica

0 NP per serving

Natrum sulphuricum

0 NP per serving

Ledum palustre

0 NP per serving

Kalmia latifolia

No known
interactions
0 NP per serving

Mountain Laurel is a flowering shrub native to North America that contains toxic compounds called grayanotoxins, making it dangerous to eat or use int...

Kalmia latifolia monograph & interactions

Ranunculus bulbosus

No known
interactions
0 NP per serving

Bulbous buttercup is a wild flowering plant that is toxic and irritating when fresh, and it is used today mainly in heavily diluted homeopathic remedi...

Ranunculus bulbosus monograph & interactions

Berberis vulgaris

Interacts with
1,210 drugs
0 NP per serving

European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolated form. S...

Berberis vulgaris monograph & interactions

Belladonna

Interacts with
196 drugs
0 NP per serving

Belladonna is a highly toxic plant whose alkaloids (like atropine and scopolamine) are powerful medicines used only in carefully controlled, regulated...

Belladonna monograph & interactions

Aurum Metallicum

0 NP per serving

Nat. Phos

0 NP per serving

Alcohol

0 NP per serving

HPUS Uricum Acidum

0 NP per serving

Glycerin

No known
interactions
0 NP per serving

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well establis...

Glycerin monograph & interactions
Interaction report

SuperFlex-H by NewtonEverett Drug Interactions

Want to check YOUR meds against SuperFlex-H?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,214Drugs
1,214 Moderate

Ingredients driving the most interactions

Berberis vulgaris 1,210
Belladonna 196
Solidago 75

Individual Drug Interactions

The ingredients in SuperFlex-H interact with 1,214 drugs. Click any drug to see the details.

3 of the 16 ingredients in SuperFlex-H interact with drugs. Each result below shows which ingredient is responsible. Berberis vulgaris Belladonna Solidago

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperFlex-H with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Berberis vulgaris8 drug types · 1,210 drugs

Anticholinergic Drugs

Theoretically, taking European barberry with anticholinergic drugs might cause additive effects.
In vitro evidence suggests that European barberry might have anticholinergic properties.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, European barberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal evidence suggest that berberine, a constituent of European barberry, might inhibit platelet aggregation. Theoretically, European barberry might have a similar effect.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking European barberry with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical evidence suggests that European barberry juice reduces fasting glucose levels in patients with type 2 diabetes who are also taking antidiabetes drugs. Additionally, some animal studies show that berberine, a constituent of European barberry, has antiglycemic potential. Monitor blood glucose levels closely.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.
Animal and human research suggests that European barberry extracts can have hypotensive effects.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, taking European barberry with cholinergic drugs might decrease the effects of cholinergic drugs.
In vitro evidence suggests that European barberry might have anticholinergic properties.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that berberine, a constituent of European barberry, might have sedative effects. Theoretically, European barberry might have a similar effect.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, concomitant use with cyclosporine may cause additive effects.
Berberine, a constituent of European barberry, can reduce the metabolism and increase serum levels of cyclosporine. This effect is attributed to the ability of berberine to inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, European barberry might have a similar effect.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.
There is very preliminary evidence suggesting that berberine, a constituent of European barberry, might inhibit the CYP3A4 enzyme. Theoretically, European barberry might have a similar effect.

Likelihood Possible Evidence D
Berberis vulgaris full monograph & interactions

Belladonna2 drug types · 196 drugs

Anticholinergic Drugs

Belladonna may increase the risk of adverse effects when used concomitantly with anticholinergic drugs.
Belladonna has anticholinergic activity and increases the activity of anticholinergic drugs.

Likelihood Probable Evidence D
Cisapride (Propulsid)

Theoretically, belladonna might reduce the effects of cisapride.
Belladonna contains atropine. In vivo evidence suggests that atropine can prevent cisapride from increasing motility in the gastrointestinal tract.

Likelihood Possible Evidence D
Belladonna full monograph & interactions

Solidago1 drug type · 75 drugs

Diuretic Drugs

Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
In vitro and animal research suggests that goldenrod has diuretic effects.

Likelihood Possible Evidence D
Solidago full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperFlex-H, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Nutraceuticals
Street Address
PO Box 27793
City
Scottsdale
State
AZ
ZipCode
85255
Phone Number
866.593.3424
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

SuperFlex-H by NewtonEverett: Common Questions

Does SuperFlex-H by NewtonEverett interact with any medications?
Yes. Based on its ingredients, SuperFlex-H has a known interaction with 1,214 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperFlex-H contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take SuperFlex-H if I'm pregnant?
No. The safety data advises against this product during pregnancy. Several ingredients—poison ivy, bryonia, mountain laurel, bulbous buttercup, and belladonna—are specifically listed as unsafe or likely unsafe in pregnancy. Talk to your doctor before considering any herbal supplement if you're pregnant.
Can I breastfeed while taking SuperFlex-H?
The product is not recommended while breastfeeding. Poison ivy, bryonia, mountain laurel, bulbous buttercup, and belladonna all have safety concerns during lactation, and belladonna's alkaloids can pass into breast milk and harm a nursing infant. Check with your doctor or pharmacist.
What is belladonna and why is it in this product?
Belladonna is a highly toxic plant used in homeopathic remedies in extremely diluted form. It's included for conditions like asthma and irritable bowel syndrome, but we have insufficient evidence that it works for these purposes. Because it's poisonous, it should only be taken in regulated products and under professional guidance.
Does this product have any fillers or inactive ingredients?
No inactive fillers are listed for this product. The formula consists of 16 active ingredients in liquid form.
Is silica safe to take long-term?
Silica from food and regular supplements is generally well tolerated, but the safety of high-dose or long-term use has not been well studied. If you're considering this product for its silica content over months or years, ask your pharmacist about the amount you'd be getting.
Can SuperFlex-H help with joint pain or arthritis?
Several ingredients—poison ivy, bryonia, and belladonna—are included for pain and arthritis conditions, but we have insufficient evidence that any of them work for these purposes. The effectiveness data we hold does not support their use for these conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SuperFlex-H is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperFlex-H label
Go deeper

The Full Monographs Behind SuperFlex-H’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Goldenrod

Interacts with 75 drugs

Goldenrod is a flowering plant traditionally used as an herbal diuretic and for urinary tract health. Human evidence is limited, and while it is generally well tolerated, people with certain...

Read the full Goldenrod monograph → Herb & supplement monograph

Poison Ivy

Poison ivy is a toxic plant best known for causing an itchy, blistering allergic rash on contact. In supplement form it is sold almost exclusively as an extremely dilute homeopathic remedy (...

Read the full Poison Ivy monograph → Herb & supplement monograph

Bryonia

Bryonia is a toxic climbing vine that is mainly used today in homeopathic dilutions for coughs, pain, and inflammation, but solid scientific evidence that it works is lacking. The raw plant...

Read the full Bryonia monograph → Herb & supplement monograph

Mountain Laurel

Mountain Laurel is a flowering shrub native to North America that contains toxic compounds called grayanotoxins, making it dangerous to eat or use internally. There is no reliable evidence t...

Read the full Mountain Laurel monograph → Herb & supplement monograph

Bulbous Buttercup

Bulbous buttercup is a wild flowering plant that is toxic and irritating when fresh, and it is used today mainly in heavily diluted homeopathic remedies. There is no solid scientific evidenc...

Read the full Bulbous Buttercup monograph → Herb & supplement monograph

European Barberry

Interacts with 1,210 drugs

European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolated form. Some early research on berberine is promi...

Read the full European Barberry monograph → Herb & supplement monograph

Belladonna

Interacts with 196 drugs

Belladonna is a highly toxic plant whose alkaloids (like atropine and scopolamine) are powerful medicines used only in carefully controlled, regulated forms. The raw plant and unregulated pr...

Read the full Belladonna monograph → Herb & supplement monograph

Glycerol

Glycerol (glycerin) is a sweet, syrupy compound made naturally in the body and widely used in foods, skin products, and medicines. It is well established as a laxative and a skin and eye moi...

Read the full Glycerol monograph →
Sources

Sources & How We Checked

SuperFlex-H's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 94 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Goldenrod 6 references
  1. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  2. Uter, W., Nohle, M., Randerath, B., and Schwanitz, H. J. Occupational contact urticaria and late-phase bronchial asthma caused by compositae pollen in a florist. Am J Contact Dermat. 2001;12(3):182-184. DOI
  3. Chodera, A., Dabrowska, K., Sloderbach, A., Skrzypczak, L., and Budzianowski, J. [Effect of flavonoid fractions of Solidago virgaurea L on diuresis and levels of electrolytes]. Acta Pol.Pharm 1991;48(5-6):35-37.
  4. Chodera, A., Dabrowska, K., Bobkiewicz-Kozlowska, T., Tkaczyk, J., Skrzypczak, L., and Budzianowski, J. [Effect of leiocarposide on experimental urinary calculi in rats]. Acta Pol.Pharm 1988;45(2):181-186.
  5. Chodera, A., Dabrowska, K., Skrzypczak, L., and Budzianowski, J. [Further studies on the diuretic effect of leiocarposide]. Acta Pol.Pharm 1986;43(5):499-503.
  6. Chodera, A., Dabrowska, K., Senczuk, M., Wasik-Olejnik, A., Skrzypczak, L., Budzianowski, J., and Ellnain-Wojtaszek, M. [Diuretic effect of the glycoside from a plant of the Solidago L. genus]. Acta Pol.Pharm 1985;42(2):199-204.

See these in context on the Goldenrod monograph →

Poison Ivy 21 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Cohen LM, Cohen JL. Erythema multiforme associated with contact dermatitis to poison ivy: three cases and a review of the literature. Cutis 1998;62:139-42.
  4. Lee, N. P. and Arriola, E. R. Poison ivy, oak, and sumac dermatitis. West J.Med. 1999;171(5-6):354-355.
  5. Kurlan, J. G. and Lucky, A. W. Black spot poison ivy: A report of 5 cases and a review of the literature. J.Am.Acad.Dermatol. 2001;45(2):246-249. PubMed
  6. CASPERS, A. P. Poison ivy (Rhus toxicodendron); a survey of the poison ivy problem in Canada and some independent observations on the value of zirconium products in prophylaxis and treatment. Can.Med Assoc.J 5-15-1957;76(10):852-860.
  7. Cardinali, C., Francalanci, S., Giomi, B., Caproni, M., Sertoli, A., and Fabbri, P. Contact dermatitis from Rhus toxicodendron in a homeopathic remedy. J Am Acad.Dermatol. 2004;50(1):150-151. PubMed
  8. Werchniak, A. E. and Schwarzenberger, K. Poison ivy: an underreported cause of erythema multiforme. J Am Acad.Dermatol. 2004;51(5 Suppl):S159-S160. PubMed
  9. Schram, S. E., Willey, A., Lee, P. K., Bohjanen, K. A., and Warshaw, E. M. Black-spot poison ivy. Dermatitis 2008;19(1):48-51. DOI
  10. Resnick, S. D. Poison-ivy and poison-oak dermatitis. Clin.Dermatol. 1986;4(2):208-212. PubMed
  11. Baer, R. L. Poison ivy dermatitis. Cutis 1986;37(6):434-436.
  12. Hurwitz, R. M., Rivera, H. P., and Guin, J. D. Black-spot poison ivy dermatitis. An acute irritant contact dermatitis superimposed upon an allergic contact dermatitis. Am.J.Dermatopathol. 1984;6(4):319-322. PubMed
  13. Schwartz, R. S. and Downham, T. F. Erythema multiforme associated with Rhus contact dermatitis. Cutis 1981;27(1):85-86.
  14. Mallory, S. B., Miller, O. F., III, and Tyler, W. B. Toxicodendron radicans dermatitis with black lacquer deposit on the skin. J.Am.Acad.Dermatol. 1982;6(3):363-368. PubMed
  15. Kollef, M. H. Adult respiratory distress syndrome after smoke inhalation from burning poison ivy. JAMA 7-26-1995;274(4):358-359. DOI
  16. Sasseville, D. and Nguyen, K. H. Allergic contact dermatitis from Rhus toxicodendron in a phytotherapeutic preparation. Contact Dermatitis 1995;32(3):182-183.
  17. Epstein, W. L. Occupational poison ivy and oak dermatitis. Dermatol.Clin. 1994;12(3):511-516. DOI
  18. Berk DR, Hurt MA, Reese LT, Wagner L, Bayliss SJ. Milia after allergic contact dermatitis from poison ivy: two cases. Dermatitis 2010;21(3):E16-8. DOI
  19. Woolery S, Willner J, Prahlow JA, Douglas E. Death After Poison Ivy Smoke Inhalation. Am J Forensic Med Pathol 2022;43(4):359-362. PubMed
  20. Rabinovich EP, Barquin JN, Abernathy RE, Koester RJ. Black-Spot Toxicodendron Dermatitis With Varied Presentation. Wilderness Environ Med 2022;33(3):351-354. PubMed
  21. Smith HD, Williams B, Beck LA, De Benedetto A. Erythema Multiforme Secondary to Poison Ivy Contact Dermatitis. Dermatitis 2023. PubMed

See these in context on the Poison Ivy monograph →

Bryonia 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Bryonia monograph →

Mountain Laurel 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Mountain Laurel monograph →

Bulbous Buttercup 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Bulbous Buttercup monograph →

European Barberry 15 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  3. Shamsa F, Ahmadiani A, Khosrokhavar R. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J Ethnopharmacol 1999;64:161-6. PubMed
  4. Fatehi M, Saleh TM, Fatehi-Hassanabad Z, et al. A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol 2005;102:46-52. PubMed
  5. Kostalova, D., Bukovsky, M., Koscova, H., and Kardosova, A. [Anticomplement activity of Mahonia aquifolium bisbenzylisoquinoline alkaloids and berberine extract]. Ceska.Slov.Farm 2001;50(6):286-289.
  6. Fatehi-Hassanabad, Z., Jafarzadeh, M., Tarhini, A., and Fatehi, M. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother Res 2005;19(3):222-225.
  7. Singh, J. and Kakkar, P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J Ethnopharmacol. 5-4-2009;123(1):22-26. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Xuan, B., Wang, W., and Li, D. X. Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1994;15(2):133-135.
  11. Gao, C. R., Zhang, J. Q., and Huang, Q. L. [Experimental study on berberin raised insulin sensitivity in insulin resistance rat models]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;17(3):162-164. DOI
  12. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  13. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  14. Lazavi F, Mirmiran P, Sohrab G, Nikpayam O, Angoorani P, Hedayati M. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: A randomized clinical trial. Complement Ther Clin Pract. 2018;31:170-174. PubMed
  15. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the European Barberry monograph →

Belladonna 20 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  5. Corazziari, E., Bontempo, I., and Anzini, F. Effects of cisapride on distal esophageal motility in humans. Dig Dis Sci 1989;34(10):1600-1605. PubMed
  6. Heindl, S., Binder, C., Desel, H., Matthies, U., Lojewski, I., Bandelow, B., Kahl, G. F., and Chemnitius, J. M. [Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagn
  7. Walach, H., Koster, H., Hennig, T., and Haag, G. The effects of homeopathic belladonna 30CH in healthy volunteers -- a randomized, double-blind experiment. J.Psychosom.Res. 2001;50(3):155-160. PubMed
  8. Davidov, M. I. [Factors predisposing to acute urine retention in patients with prostatic adenoma]. Urologiia. 2007;(2):25-31.
  9. Williams HC and du Vivier A. Belladonna plaster--not as bella as it seems. Contact Dermatitis 1990;23(2):119-120.
  10. Stieg, R. L. Double-blind study of belladonna-ergotamine-phenobarbital for interval treatment of recurrent throbbing headache. Headache 1977;17(3):120-124. PubMed
  11. Shader RI and Greenblatt DJ. Uses and toxicity of belladonna alkaloids and synthetic anticholinergics. Seminars in Psychiatry 1971;3(4):449-476.
  12. Gabel MC. Purposeful ingestion of belladonna for hallucinatory effects. J.Pediatr. 1968;72(6):864-866. PubMed
  13. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204(2):169-170. DOI
  14. Schneider, F., Lutun, P., Kintz, P., Astruc, D., Flesch, F., and Tempe, J. D. Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 1996;34(1):113-117. PubMed
  15. Ceha LJ, Presperin C, Young E, and et al. Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine. The Journal of Emergency Medicine 1997;15(1):65-69. PubMed
  16. Firth D and Bentley JR. Belladonna poisoning from eating rabbit. Lancet 1921;2:901. DOI
  17. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204(11):153. DOI
  18. Hamilton M and Sclare AB. Belladonna poisoning. Br Med J 1947;611-612. PubMed
  19. Huff ML, Fikse D, Surmaitis RM, Greenberg MR. Acute angle closure glaucoma precipitated by homeopathic eyedrops containing Atropa belladonna. Am J Emerg Med. 2021 Nov 3:S0735-6757(21)00902-5. PubMed
  20. Chen L, Yeung JC, Anderson DR. Anisocoria secondary to anticholinergic mydriasis from homeopathic pink eye relief drops. Clin Med Res. 2017;15(3-4):93-5. PubMed

See these in context on the Belladonna monograph →

Glycerol 8 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Wagner DR. Hyperhydrating with glycerol: implications for athletic performance. J Am Diet Assoc 1999;99:207-12. PubMed
  3. Yu YL, Kumana CR, Lauder IJ, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24. PubMed
  4. Frei A, Cottier C, Wunderlich P, Ludin E. Glycerol and dextran combined in the therapy of acute stroke. A placebo-controlled, double-blind trial with a planned interim analysis. Stroke 1987;18:373-9. PubMed
  5. Balaskas E, Szepietowski JC, Bessis D, Ioannides D, Ponticelli C, Ghienne C, Taberly A, Dupuy P. Randomized, double-blind study with glycerol and paraffin in uremic xerosis. Clin J Am Soc Nephrol. 2011 Apr;6(4):748-52. PubMed
  6. Blanchet-Bardon C, Tadini G, Machado Matos M, Delarue A. Association of glycerol and paraffin in the treatment of ichthyosis in children: an international, multicentric, randomized, controlled, double-blind study. J Eur Acad Dermatol Venereol. 2012 Aug;26 PubMed
  7. Kajita N, Kanamori K, Yamamoto S, Yoshida K. Generalized Urticaria Caused by a Glycerin Enema in an Infant. J Investig Allergol Clin Immunol 2022;32(4):318-319. PubMed
  8. Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Reports. 2016;2:108-10. PubMed

See these in context on the Glycerol monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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