5-HTP SAP 50 mg Ingredients & Drug Interactions
by NFH
What is this page for?
First and foremost: checking 5-HTP SAP 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
5-HTP SAP 50 mg is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 398 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-5-Hydroxytryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 5-HTP SAP 50 mg by NFH
Ask about any prescription or over-the-counter medication and we check it for interactions with 5-HTP SAP 50 mg by NFH — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 5-HTP SAP 50 mg by NFH
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: L-5-hydroxytryptophan (5-HTP), a compound your body naturally makes on the way to producing serotonin, a brain chemical involved in mood and sleep. The capsule also contains inactive ingredients — magnesium stearate, silicon dioxide, and microcrystalline cellulose — that are fillers and binders.
Does it work?
Moderate evidence
For depression, the evidence suggests 5-HTP is possibly effective — meaning some studies support it, but the picture isn't yet complete. For Down syndrome, the data points toward it being possibly ineffective.
For other conditions we hold ratings on — Alzheimer's disease, panic disorder, and cerebellar ataxia — the evidence isn't established enough for us to say either way.
How safe is it?
Well-documented data
Orally, 5-HTP is generally well tolerated in the short term. Common side effects include stomach pain, loss of appetite, dizziness, diarrhea, drowsiness, fatigue, headache, sleep problems, nausea, and vomiting — and these tend to depend on dose.
Some people report these ease up with continued use. Serious side effects are rare but can include aggression, hallucinations, mood elevation (mania), and severe stomach complaints.
Because 5-HTP affects serotonin, use it with care and under professional guidance. The safety data advises against using 5-HTP during pregnancy or while breastfeeding due to insufficient information.
If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before starting.
Meds to double-check
Moderate interaction found
Before you take this, double-check with your pharmacist if you're on serotonergic drugs (antidepressants, certain migraine medications), CNS depressants (sleeping pills, sedatives, opioids), or carbidopa (a Parkinson's medication). The interaction data we hold covers these drug types.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
5-HTP may help some people with depression, but it carries interaction risks with common medications and can cause side effects. If you take any antidepressants, migraine drugs, sedatives, or carbidopa, check with your pharmacist or doctor first.
Talk to your pharmacist — they can help you weigh the benefits and risks for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 5-HTP SAP 50 mg, straight from the product label.
| Brand | NFH |
|---|---|
| Barcode (UPC) | 856711001757 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 273232 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 5-HTP SAP 50 mg by NFH, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-5-Hydroxytryptophan | 50 mg | -- |
Other ingredients: Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose, Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
5-HTP SAP naturally supports serotonin production, helping to regulate normal sleep, positive mood, appetite control, and body temperature.
Formulation
All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.
Contains no: Gluten, soy, wheat, corn, eggs, dairy, preservatives, artificial flavor or color, sugar, or starch.
This product is non-GMO and vegan friendly.
This product is non-GMO and vegan friendly.
Color, size and smell may vary from one lot to another.
Supports serotonin production
Made in Canada
Suggested/Recommended/Usage/Directions
Directions for use: Adults: Take 1-2 capsules three times daily or as directed by your healthcare practitioner.
Precautions
Cautions and warnings: Some patients experience nausea or gastrointestinal upset and drowsiness when taking 5-HTP. If this occurs, please discuss dosing with your healthcare practitioner.
Please consult your healthcare practitioner before using this product if you are taking medications or supplements that have serotonergic activity; these include many antidepressants, St. John's wort, L-tryptophan, cold medications containing the ingredient dextromethorphan and some antimigraine medications. Consult your healthcare practitioner before using if you are pregnant or breast-feeding.
Do not use if seal is broken.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General Statements
NPN 80029764
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
5-HTP SAP 50 mg by NFH label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 5-HTP SAP 50 mg by NFH
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
L-5-Hydroxytryptophan
Interacts with398 drugs
5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...
L-5-Hydroxytryptophan monograph & interactionsOther (inactive) ingredients: Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose, Capsule. These complete the product’s ingredient list but are not active constituents.
5-HTP SAP 50 mg by NFH Drug Interactions
HelloPharmacist Interaction Report
NFH's 5-HTP SAP contains L-5-hydroxytryptophan, which does interact with medications.
The most serious concern is with serotonergic drugs — that's antidepressants, migraine drugs, and other medications that work on serotonin. Combining 5-HTP with these can raise the risk of serotonin syndrome (a dangerous buildup of serotonin in your system) and cerebral blood vessel constriction.
This is rated Moderate severity.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to flag CNS depressants (sedatives, sleep aids, opioids, alcohol) with your pharmacist or doctor. 5-HTP can add to their drowsiness effect.
There's also a Moderate interaction with carbidopa (Lodosyn, a Parkinson's medication) — the combination can boost serotonergic side effects and raise the risk of agitation, rapid speech, anxiety, and sleep problems.
Although the ingredient we checked shows documented interactions, we do hold drug interaction data for this product. Altogether, these interactions span 398 individual medications.
Use the medication checker on this page to search your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against 5-HTP SAP 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 5-HTP SAP 50 mg interact with 398 drugs. Click any drug to see the details.
1 of the 1 ingredient in 5-HTP SAP 50 mg interact with drugs. Each result below shows which ingredient is responsible. L-5-Hydroxytryptophan
AripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs, Cns Depressants Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Aripiprazole Lauroxil interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Hydrocodone interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Aspirin, Pentazocine interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl SalicylateUrinary Antiseptic 2, Urised
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Atropine, Morphine Sulfate interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanSerotonergic Drugs Moderate
Interaction Summary
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
Read the full L-5-hydroxytryptophan + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with 5-HTP SAP 50 mg — through 1 ingredient. Tap an ingredient for the detail:
L-5-hydroxytryptophanCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
Read the full L-5-hydroxytryptophan + Belladonna Alkaloids, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 5-HTP SAP 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-5-Hydroxytryptophan
Carbidopa (Lodosyn)
Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.
Cns Depressants
Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.
Serotonergic Drugs
Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.
Brand information
Manufacturer and brand details for 5-HTP SAP 50 mg, from the product label.
NFH
See all NFH products- Name
- NFH - Nutritional Fundamentals for Health, Inc.
- Street Address
- 351 Rue Joseph-Carrier
- City
- Vaudreuil
- State
- QC
- ZipCode
- J7V 5V5
- Phone Number
- 1 866 510-3123
- Web Address
- nfh.ca
5-HTP SAP 50 mg by NFH: Common Questions
Does 5-HTP SAP 50 mg by NFH interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does 5-HTP actually do?
What are the most common side effects?
Can I take this if I'm on an antidepressant?
Is 5-HTP safe during pregnancy or breastfeeding?
Does this actually work for depression?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if 5-HTP SAP 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 5-HTP SAP 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
5-HTP SAP 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
5-htp 32 references
- Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
- Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
- Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
- U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
- Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
- Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
- Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
- U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
- Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
- Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
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