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Dietary supplement

Acidophilus Ingredients & Drug Interactions

by Member's Mark

Acidophilus label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Acidophilus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Acidophilus is a dietary supplement by Member's Mark with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioflora(R). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Acidophilus by Member's Mark

Ask about any prescription or over-the-counter medication and we check it for interactions with Acidophilus by Member's Mark — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Acidophilus by Member's Mark

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Bioflora(R)” is listed as a grouped ingredient — the label gives one combined amount (10 mg) without saying how much of each component you get.

Member's Mark Acidophilus is a single-ingredient probiotic supplement containing active Lactobacillus acidophilus, a beneficial bacterium that naturally lives in your gut and helps support digestive and immune health. The supplement also contains several inactive ingredients — cellulose, silica, stearic acid, and vegetable magnesium stearate — which are fillers and binders that help form and preserve the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support intestinal health and nutrient absorption.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance.

L. acidophilus has possibly effective evidence for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea (when taken after antibiotics), and bacterial vaginosis. The evidence for atopic disease (allergic conditions) leans toward ineffective, and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. acidophilus is generally well tolerated in healthy adults and children. Since it contains live organisms, there is some concern it could theoretically cause infection in certain vulnerable patients — most reported cases involved bacteria that moved from other parts of the body where they naturally live.

When combined with other probiotics, a small number of people have reported mild gastrointestinal side effects like bloating, flatulence, abdominal pain, or diarrhea, though these are uncommon. Because the data are limited, check with your doctor before starting this product.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the one medication type documented to interact with L. acidophilus — taking them together may reduce how well the probiotic works, so separate your doses. Before starting this supplement, check the medication search tool on this page with any antibiotics you're on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L. acidophilus is a reasonable choice if you're dealing with irritable bowel syndrome, antibiotic-related diarrhea, or bacterial vaginosis and want probiotic support. The main thing to watch: if you're on antibiotics, space out when you take them from when you take this supplement so the antibiotic doesn't kill off the live bacteria.

Talk to your pharmacist about dosing timing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Acidophilus, straight from the product label.

Brand Member's Mark
Barcode (UPC) 078742093796
Net contents 150 Caplet(s)
Market status On market
Date entered into DSLD Jun 25, 2015
DSLD ID 46802
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Acidophilus by Member's Mark, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
UPC/BARCODE
078742093796
IngredientAmount% DV
Bioflora(R)10 mg--
active Lactobacillus acidophilus2000000000 {Unit(s)}--

Other ingredients: Cellulose, Silica, Stearic Acid, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NUTRITION INFORMATION: Acidophilus supports a favorable environment for the asborption of nutrients, encourages normal intestinal microflora balance, and supports the healthy functioning of the intestinal system.*

{Caplet} actual size

Ultimate Probiotic Formula

- 2 billion active cultures**

As a reminder, discuss the supplements and medications you take with your health care providers.

**2 billion live organisms per caplet at time of manufacture

FRESHNESS & POTENCY GUARANTEED THROUGH.

Prod No. 58866 B27614 00A

For comments or suggestions, call us toll-free at 1.888.667.8678 from 8 a.m. to 5 p.m. CST Monday - Friday

Supports Intestinal Health*

Precautions

KEEP OUT OF THE REACH OF CHILDREN.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Tamper resistant: Do not use if seal under cap is broken or missing.

FDA Statement of Identity

dietary supplement

Formula

- Made with BIOFLORA(R)

Suggested/Recommended/Usage/Directions

- 1 caplet per day

Suggested Use: For adults, take one (1) caplet daily, preferably with a meal.

Storage

Refrigerate after opening

Store unopened container at room temperature, tightly closed and avoid excessive heat.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

No gluten No wheat No milk or milk derivatives No lactose No sugar No preservatives No soy No artificial color No artificial flavor No sodium (less than 5 mg per serving).

Seals/Symbols

GLUTEN FREE

M Member's Mark(R) QUALITY GUARANTEED

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Acidophilus by Member's Mark label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Acidophilus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Acidophilus by Member's Mark

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Bioflora(R)

Interacts with
182 drugs
10 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Bioflora(R) monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Stearic Acid, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Acidophilus by Member's Mark Drug Interactions

Want to check YOUR meds against Acidophilus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bioflora(R) 182

Individual Drug Interactions

The ingredients in Acidophilus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Acidophilus interact with drugs. Each result below shows which ingredient is responsible. Bioflora(R)

Each ingredient & the kinds of drugs it affects

For each ingredient in Acidophilus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioflora(R)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Bioflora(R) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Acidophilus, from the product label.

Member's Mark

Name
SAM'S WEST, INC.
City
BENTONVILLE
State
AR
ZipCode
72716
Pharmacist Counseling Corner

Acidophilus by Member's Mark: Common Questions

Does Acidophilus by Member's Mark interact with any medications?
Yes. Based on its ingredients, Acidophilus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Acidophilus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm taking antibiotics?
L. acidophilus is possibly effective for antibiotic-associated diarrhea, but you need to time it right. Antibiotics can kill the live organisms, so ask your pharmacist how many hours to wait between doses — don't take them at the same time.
What are the side effects?
L. acidophilus is generally well tolerated. When combined with other probiotics, some people report mild digestive upset like bloating or flatulence, but these are uncommon. Very rarely, in vulnerable patients, the bacteria could theoretically cause infection.
Is this safe to take if I'm pregnant?
The data on L. acidophilus in pregnancy is limited — it's rated possibly safe, but there isn't enough information to know either way. Talk with your doctor or pharmacist before starting it.
Does this actually work for IBS?
L. acidophilus has possibly effective evidence for irritable bowel syndrome, which means the data suggest it may help, but the evidence isn't definitive. Results vary from person to person.
What is Lactobacillus acidophilus?
It's a live, beneficial bacterium that naturally lives in your gut. It supports digestive and immune health. This supplement adds more of these organisms to help maintain a healthy microbiome.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Acidophilus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Acidophilus label
Go deeper

The Full Monographs Behind Acidophilus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Acidophilus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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