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Dietary supplement

Alpha GPC 300 mg Ingredients & Drug Interactions

by NOW

Alpha GPC 300 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 300 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 300 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 300 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Alpha GPC 300 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-GPC (also called L-alpha-glycerylphosphorylcholine), a compound that plays a role in how your brain cells communicate and maintain their structure. The capsule also contains several inactive ingredients — cellulose, silica, stearic acid, and magnesium stearate — which are fillers and binders that hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cognitive support and mental acuity.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, Memory, Age-related cognitive decline.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

For Alzheimer disease, alpha-GPC is rated possibly effective, meaning there's some evidence it may help but more research is needed to be certain. For brain tumors, cognitive function, vascular dementia, and stroke, the evidence isn't established well enough in our data to rate it one way or the other.

If you're considering it for any of these conditions, that's a conversation to have with your doctor.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, but long-term safety hasn't been fully established. Rarely, it's been linked to dizziness, headache, insomnia, excitation, diarrhea, heartburn, nausea, and vomiting.

More concerning, alpha-GPC used for at least 2 months has been rarely associated with an elevated stroke risk compared with non-users or those who used it for less than 2 months. We don't have enough safety data for pregnancy or breastfeeding — talk with your doctor before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're taking scopolamine (Transderm Scop), a motion sickness patch, double-check with your pharmacist before adding alpha-GPC — it might reduce how well the patch works to prevent nausea. No other Major or Moderate interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC might be worth considering if you're exploring options for Alzheimer disease, but the evidence for other uses isn't clear yet. If you're on a scopolamine patch or any prescription medication, check with your pharmacist first.

Long-term safety and stroke risk over 2+ months of use are questions to discuss with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 300 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739030856
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD May 22, 2016
DSLD ID 59894
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 300 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
30
UPC/BARCODE
733739030856
IngredientAmount% DV
Alpha GPC600 mg--

Other ingredients: Cellulose, Cellulose powder, Silica, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

~ Bioavailable Source of Choline

Contains soy (Alpha GPC from soy lecithin).

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat Freshness Packet. Keep in Bottle.

Contains soy (Alpha GPC from soy lecithin).

Not manufactured with yeast, wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

General

CODE 3085 V3

General Statements

CAPSULE SIZE

Cognitive Support* ~ Bioavailable Source of Choline ~ Supports Mental Acuity*

General Health

Family owned since 1968.

Natural color variation may occur in this product.

Alpha GPC is a natural physiological precursor to acetyl-choline, a neurotransmitter that is involved in memory and other cognitive functions.* Alpha GPC is more bioavailable than other forms of choline and is known to cross the blood-brain barrier. In the brain and other neural tissues, Alpha GPC becomes a constituent of cell membranes.* Clinical studies have demonstrated that supplementation with Alpha GPC can support the brain’s synthesis of acetyl-choline.* In this way, it helps to promote normal cognitive function and mental acuity.*

Please Recycle.

FDA Statement of Identity

A Dietary Supplement

Formulation

Vegetarian/Vegan

Not manufactured with yeast, wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients.

Storage

Store in a cool, dry place after opening.

Seals/Symbols

GMP QUALITY ASSURED

Suggested/Recommended/Usage/Directions

Suggested Usage: Take 2 capsules twice daily with food. Best when taken early in the day.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 300 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 300 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Alpha GPC

Interacts with
16 drugs
600 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha GPC monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose powder, Silica, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha GPC 300 mg by NOW Drug Interactions

Want to check YOUR meds against Alpha GPC 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha GPC 16

Individual Drug Interactions

The ingredients in Alpha GPC 300 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 300 mg interact with drugs. Each result below shows which ingredient is responsible. Alpha GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 300 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Alpha GPC 300 mg by NOW: Common Questions

Does Alpha GPC 300 mg by NOW interact with any medications?
Yes. Based on its ingredients, Alpha GPC 300 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC and what does it do?
Alpha-GPC is a compound that helps your brain cells communicate and stay healthy. Your body actually makes some naturally, and it's thought to support memory and cognitive function, though the evidence is still being studied.
Does this product actually work?
For Alzheimer disease, there's some evidence it may help — that's why it's rated possibly effective. For other uses like general cognitive function or stroke, we don't have enough reliable evidence yet to say whether it works.
What side effects should I watch for?
Most people tolerate it well, but rarely it's been linked to dizziness, headache, insomnia, nausea, or heartburn. If you use it for 2 months or longer, there's been a rare association with stroke — that's worth discussing with your doctor before you start.
Is it safe to take during pregnancy or while breastfeeding?
We don't have enough safety data to know either way. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.
I use a scopolamine patch for motion sickness. Can I take alpha-GPC?
Check with your pharmacist first. Alpha-GPC might weaken how well the patch works, though we don't know for certain yet. Your pharmacist can help you decide if it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 300 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 300 mg label
Go deeper

The Full Monographs Behind Alpha GPC 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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