Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

American Ginseng 480 mg Ingredients & Drug Interactions

by Solaray

Capsule Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

American Ginseng 480 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for stress and energy support, immune support and colds, blood sugar management.Based on those ingredients, 217 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are American Ginseng. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of American Ginseng 480 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: American ginseng at 480 mg per capsule. American ginseng is a plant root used traditionally to support immune function and overall wellness.

The capsule also holds two inactive ingredients — cellulose and a rice bran extract blend — which are fillers and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see American Ginseng's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Stress support.
  • We looked for evidence on: Cancer-related fatigue, Cardiovascular disease (CVD), Cognitive function, Menopausal symptoms, Anxiety, Energy and fatigue — and 2 related terms.
  • The closest evidence on file: American Ginseng is rated "Insufficient Reliable Evidence To Rate" for Cancer-related fatigue (Natural Medicines).
  • Also on file: American Ginseng is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Cognitive function, Menopausal symptoms.

The evidence we hold shows American ginseng is possibly effective for upper respiratory tract infections (URTI), like colds. For other uses — anemia of chronic disease and breast cancer — the evidence isn't strong enough to rate, meaning more research is needed to know if it works.

The evidence, ingredient by ingredient American Ginseng

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

American ginseng is generally well tolerated when taken short-term by healthy adults, though quality and dosing vary between products and long-term safety hasn't been studied carefully. The main side effect reported is headache.

The safety data advises against use during pregnancy because some lab research raises concern. There isn't enough information to know if it's safe while breastfeeding, so avoidance is the safer choice — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient American Ginseng

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — American Ginseng.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 217 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check your medications against this list: warfarin or other blood thinners (Major severity), then diabetes medications, immunosuppressants, and MAOIs or older antidepressants (all Moderate severity). Use the search tool on this page with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

American ginseng may help with cold symptoms, but it's not a product you can just add to your routine without checking with medications first — especially if you take warfarin, diabetes drugs, immunosuppressants, or older antidepressants. It's also not recommended in pregnancy or while breastfeeding.

If none of those apply and you're curious about it for a cold, have a quick conversation with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about American Ginseng 480 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280013108
Net contents 50 VegCap(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 338832
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for American Ginseng 480 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
50
UPC/BARCODE
076280013108
IngredientAmount% DV
American Ginseng480 mg--

Other ingredients: Cellulose, Rice Bran Extract Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A Brighter Way 1973

General Statements

True Herbs

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles

Formulation

Stress support

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified Vegan

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water.

Storage

Store in a cool, dry place.

Formula

Discussion: Native to North America, American ginseng is a perennial herb herb in the ivy family. American ginseng first attracted attention in the 1700's when Jesuits realized its similarity to the ginseng found in Asia. American ginseng is known as an adaptogen, a unique class of herbs that help support the body's ability to adapt to physical and mental stress.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

American Ginseng 480 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in American Ginseng 480 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

American Ginseng

Interacts with
217 drugs
480 mg per serving

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...

American Ginseng monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Bran Extract Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

American Ginseng 480 mg by Solaray Drug Interactions

Want to check YOUR meds against American Ginseng 480 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
217Drugs
2 Major 215 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in American Ginseng 480 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

American Ginseng4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for American Ginseng 480 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

American Ginseng 480 mg by Solaray: Common Questions

Does American Ginseng 480 mg by Solaray interact with any medications?
Yes. Based on its ingredients, American Ginseng 480 mg has a known interaction with 217 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
American Ginseng 480 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is American ginseng supposed to do?
The evidence we have shows it's possibly effective for upper respiratory tract infections — things like colds. The evidence for other uses like anemia or breast cancer is too limited to say whether it works.
Can I take this if I'm pregnant?
The safety data advises against it. Some lab research raises concern, so it's best avoided during pregnancy. Talk with your doctor or pharmacist about what's right for you.
Can I take this while breastfeeding?
There isn't enough information to know if it's safe, so avoidance is the safer choice. Check with your doctor or pharmacist for personalized advice.
Are there any side effects?
Headache has been reported with American ginseng use. The product is generally well tolerated short-term in healthy adults, though long-term safety hasn't been well studied.
Does this have any fillers?
Yes — the capsule contains cellulose and a rice bran extract blend as inactive ingredients to hold the ginseng together.
Why does this interact with so many medications?
American ginseng affects how your immune system works and can lower blood sugar. Those changes mean it can interfere with drugs that control blood thinning, blood sugar, immune suppression, and certain antidepressants — adding up to many individual medications across those categories.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if American Ginseng 480 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

American Ginseng 480 mg label
Sources

Sources & How We Checked

American Ginseng 480 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

American Ginseng 12 references
  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  7. McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
  8. Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
  9. Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
  10. McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
  11. Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
  12. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

See these in context on the American Ginseng monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring