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Dietary supplement

American Ginseng Extract Ingredients & Drug Interactions

by NOW

Capsule Category: Botanical
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

American Ginseng Extract is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for stress and energy support, immune support and colds, blood sugar management.Based on those ingredients, 217 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are American Ginseng Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of American Ginseng Extract by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: American ginseng root extract. The capsule also holds two inactive ingredients—hypromellose and ascorbyl palmitate—which serve as a capsule shell and preservative.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: adaptogenic herb for stress energy and wellness.
  • We looked for evidence on: Athletic performance, Cancer-related fatigue, Cognitive function, Diabetes, Upper respiratory tract infection (URTI), Stress resilience — and 3 related terms.
  • The strongest evidence on file: American Ginseng is rated "Possibly Effective" for Upper respiratory tract infection (URTI) (Natural Medicines).
  • Also on file: American Ginseng is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Cancer-related fatigue, Cognitive function, Diabetes.

American ginseng is possibly effective for upper respiratory tract infections (the common cold and similar viral infections). The evidence for other uses—anemia of chronic disease and breast cancer—is not established in our data.

The evidence, ingredient by ingredient American Ginseng

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

American ginseng is generally well tolerated in the short term by healthy adults, though quality and dosage vary between products and long-term safety hasn't been well studied. Headache has been reported.

The safety data advises against use during pregnancy, and there isn't enough information to know whether it's safe while breastfeeding—talk with your doctor or pharmacist for personalized guidance on both.

Side effects, ingredient by ingredient American Ginseng

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — American Ginseng.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 217 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check your exact medications against the list on this page if you take warfarin, immunosuppressants, diabetes drugs, or MAOIs—American ginseng can affect how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This supplement may help with cold symptoms, but if you take warfarin, immunosuppressants, diabetes medication, or MAOIs, you'll need to check with your pharmacist first. It's not recommended in pregnancy or while nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about American Ginseng Extract, straight from the product label.

Brand NOW
Barcode (UPC) 733739040046
Net contents 100 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313562
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for American Ginseng Extract by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
50
UPC/BARCODE
733739040046
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
American Ginseng Root Extract1 Gram(s)--

Other ingredients: Hypromellose, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 2 capsules 1 to 3 times daily as needed.

Formula

American Ginseng has been used by traditional herbalists for centuries. Scientific data confirm the presence of bioactive compounds in American ginseng, known as ginsenosides, which confer this herb’s adaptogenic properties.

Triangle K (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Do not use if pregnant/nursing. Consult physician if taking medication (especially diabetes and blood thinning medications) or have a medical condition (especially diabetes or hypoglycemia).

Keep out of reach of children.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Adaptogenic Herb

Non-GMO

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

Made and quality tested in the USA with globally sourced ingredients.

General Statements

This bottle is made from 100% PCR (post-consumer recycled) resin.

Botanicals/Herbs Family owned since 1968.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP QUALITY ASSURED

Storage

Store in a cool, dry place after opening.

See for yourself

American Ginseng Extract by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in American Ginseng Extract by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

American Ginseng Root Extract

Interacts with
217 drugs
1 Gram(s) per serving Form: Maltodextrin

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the...

American Ginseng Root Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

American Ginseng Extract by NOW Drug Interactions

Want to check YOUR meds against American Ginseng Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
217Drugs
2 Major 215 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in American Ginseng Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

American Ginseng Root Extract4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for American Ginseng Extract, from the product label.

NOW

See all NOW products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

American Ginseng Extract by NOW: Common Questions

Does American Ginseng Extract by NOW interact with any medications?
Yes. Based on its ingredients, American Ginseng Extract has a known interaction with 217 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
American Ginseng Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is American ginseng safe to take long-term?
It's generally well tolerated in the short term, but we don't have solid data on long-term safety, and quality and dosing vary between brands. Talk with your pharmacist about how long you plan to use it.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against use during pregnancy. There isn't enough information to know whether it's safe while breastfeeding. Talk with your doctor or pharmacist before use in either case.
What side effects might I notice?
Headache is the side effect reported in our data. Most people don't have problems, but if you do develop headaches or other symptoms, mention it to your pharmacist or doctor.
Does this really help with colds?
American ginseng is possibly effective for upper respiratory infections like colds. That means some evidence supports it, but it's not a guaranteed cure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if American Ginseng Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

American Ginseng Extract label
Sources

Sources & How We Checked

American Ginseng Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

American Ginseng 12 references
  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  7. McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
  8. Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
  9. Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
  10. McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
  11. Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
  12. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

See these in context on the American Ginseng monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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